Aneurysm Creation
Aneurysm Creation - Related Videos
10:23
Creation of Murine Experimental Abdominal Aortic Aneurysms with Elastase
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Cited by 55 •
2009
This video shows how to induce abdominal aortic aneurysms (AAA) in mice via transient intraluminal infusion of porcine pancreatic elastase into the infrarenal segment of the abdominal aorta. The model has the ability to add broad insight into the pathobiology of AAA due to the emergence of numerous transgenic and gene knockout mice.
08:54
Reliable Creation of a Murine Abdominal Aortic Aneurysm Model Using Elastin Sensitization and Perivascular Elastase
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2026
This protocol provides a repeatable and reliable method for inducing abdominal aortic aneurysms (AAAs) in C57BL/6 mice using elastin sensitization and perivascular elastase application, as an AAA model that incorporates an immune-sensitization component.
08:37
Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
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Cited by 12 •
2017
Polyurethane catheter insertion into the aortic lumen and suture ligation of the aorta induce chronic hypoxia due to hypoperfusion of the adventitial vasa vasorum. This article describes a novel animal model of abdominal aortic aneurysm (AAA) with characteristics similar to those of AAA in humans.
07:04
Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit
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Cited by 2 •
2021
This protocol describes the steps for the creation of a rabbit model with two elastase-digested aneurysms with different hemodynamics (stump and bifurcation constellation). This allows the testing of novel endovascular devices in aneurysms with different angioarchitecture and hemodynamic conditions within a single animal.
13:53
The Helsinki Rat Microsurgical Sidewall Aneurysm Model
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Cited by 21 •
2014
Microsurgical sidewall aneurysms in rats are created by end-to-side anastomosis of an aortic graft to the abdominal aorta. We present step-by-step instructions and discuss anatomical and surgical details for successful experimental saccular aneurysm creation.
FAQs
After the vessel wall has been structurally weakened or blood flow has been changed, arterial pressure acts on the altered region and can promote progressive enlargement. This relationship allows investigators to examine how hemodynamic forces contribute to aneurysm development over time, while controlled experimental conditions help separate pressure- and flow-related effects from other features of vascular disease.
These models support analysis of several connected processes, including vascular wall remodeling, thrombosis, and factors associated with rupture risk. Examining these outcomes together is important because aneurysm progression is not represented only by changes in vessel size. The model therefore provides a setting for relating altered vessel structure and hemodynamics to clinically relevant disease behavior.
The strategies alter different experimental features of the vessel system. Surgical manipulation can modify vessel structure, ligation can alter the vascular arrangement and flow environment, and targeted weakening directly changes wall integrity. Selecting among them depends on which aspect of aneurysm biology researchers need to emphasize, such as hemodynamics, structural remodeling, thrombosis, or rupture risk.
A typical workflow begins by modifying the vessel structure or blood-flow conditions through an appropriate experimental intervention. The altered vessel is then studied under arterial pressure, which can drive progressive enlargement. Investigators monitor the resulting model to examine wall remodeling, thrombosis, hemodynamics, or rupture-related features under controlled preclinical conditions.
Aneurysm creation is used when investigators need preclinical evidence about aneurysm biology or prospective treatments. The resulting models can support evaluation of imaging methods, endovascular devices, surgical techniques, and pharmacological interventions. Their value lies in allowing these approaches to be examined in a controlled vascular setting before clinical translation is considered.
Researchers can assess how candidate interventions perform in relation to aneurysm structure and behavior, including effects relevant to hemodynamics, wall remodeling, thrombosis, and rupture risk. Models may also provide evidence about imaging performance, device behavior, surgical approaches, or drug effects. These findings help determine whether an intervention merits further development toward clinical use.