Animal Imaging
Animal Imaging - Related Videos
01:37
Non-invasive Monitoring and Imaging in Animal Research
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2026
All animal procedures described here must be conducted in accordance with institutional animal ethics guidelines and approved by IACUC. All procedures must follow the principles of the 3Rs—Replacement, Reduction, and Refinement—and must be performed by trained personnel. Non-invasive technologies support the principles of 3Rs by enabling repeated data collection from the same animal without the need for euthanasia at multiple time points. These approaches reduce the number of animals required...
09:17
Bioluminescence Imaging of an Immunocompetent Animal Model for Glioblastoma
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Cited by 13 •
2016
GL261 glioma cells provide a useful immunocompetent animal model of glioblastoma. The goals of this protocol are to demonstrate proper techniques for monitoring intracranial tumor growth using in vivo bioluminescence imaging, and to verify the utility of luciferase-modified GL261 cells for studying tumor immunology and immunotherapeutic approaches for treating glioblastoma.
05:32
A High-performance Compact Photoacoustic Tomography System for In Vivo Small-animal Brain Imaging
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Cited by 11 •
2017
A compact pulsed-laser diode-based photoacoustic tomography (PLD-PAT) system for high-speed in vivo brain imaging in small animals is demonstrated.
26:43
Computer-Generated Animal Model Stimuli
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Cited by 8 •
2007
Computer-generated stimuli using the Jacky dragon as a model.
10:42
Bioluminescence Imaging of NADPH Oxidase Activity in Different Animal Models
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Cited by 16 •
2012
NADPH oxidase is the major source of reactive oxygen species (ROS) in phagocytes. Because of the ephemeral nature of ROS, it is difficult to measure and monitor ROS levels in living animals. A minimally invasive method for serial quantification of ROS in living mice is described.
FAQs
Each modality emphasizes a different biological feature. X-ray images reflect tissue-dependent attenuation, ultrasound displays echoes from sound waves, MRI maps responses to magnetic fields and radiofrequency pulses, and PET shows where radiolabeled tracers distribute. Consequently, modality selection depends on whether the investigation prioritizes structural differences, physiological information, organ function, or tracer localization.
Repeated imaging allows investigators to follow changes in the same living animal over time rather than relying only on separate observations at different time points. This supports longitudinal assessment of tumor growth, organ function, disease progression, and treatment response. The noninvasive approach can provide serial information while avoiding procedures that would interrupt ongoing observation.
Anatomical information concerns physical structure and tissue-related differences, whereas physiological information concerns how organs or disease processes function. X-rays and MRI can contribute structural information through their measured signals, while ultrasound detects wave echoes and PET tracks radiolabeled tracer distribution. Comparing these signal types helps align the imaging readout with the biological question.
Researchers match the modality to the feature they need to evaluate. Tissue-dependent attenuation may be appropriate when structural differences are central, while MRI responses, ultrasound echoes, or PET tracer distribution may better address other anatomical or functional questions. This choice determines which aspects of disease, organ behavior, or treatment response become measurable in the study.
Imaging can provide repeated observations of tumor growth, organ function, disease progression, and responses to treatment. These outcomes allow researchers to relate visible or measurable changes to the course of an experiment instead of evaluating disease only at a single endpoint. The resulting information supports assessment of how a condition changes and whether an intervention produces a response.
In veterinary care, imaging supplies information relevant to evaluating living animals. In biomedical research, it supports preclinical evaluation and helps investigators study disease mechanisms before relating findings to human health. Because the same general approaches can monitor anatomy, physiology, disease, and treatment response, animal imaging provides a bridge between experimental observations and medically relevant questions.