Auto-transplantation
Auto-transplantation - Related Videos
08:02
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
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Cited by 62 •
2012
A description of the surgical induction of endometriosis in mice and rats by auto-transplantation of uterine tissue to the arterial cascade of the intestinal mesentery.
07:58
Orthotopic Kidney Auto-Transplantation in a Porcine Model Using 24 Hours Organ Preservation And Continuous Telemetry
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Cited by 6 •
2020
Large animal models play an essential role in preclinical transplantation research. Due to its similarities to the clinical setup, the porcine model of orthotopic kidney auto-transplantation described in this article provides an excellent in vivo setting for the testing of organ preservation techniques and therapeutic interventions.
08:15
Cervical Heterotopic Mouse Heart Transplantation using End-to-side Anastomosis Technique to Study Transplant Immunology
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2026
This protocol presents a simplified, end-to-side suture anastomosis technique for murine cervical heart transplantation, providing a robust and reproducible model for studying transplant immunology.
11:29
A Modified Method for Heterotopic Mouse Heart Transplantion
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Cited by 5 •
2014
A technique is demonstrated for the microsurgical procedure for heterotopic transplantation of hearts in mice, including simplified methods for donor harvesting and recipient vessel anastomosis.
07:59
Murine Full-thickness Skin Transplantation
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Cited by 41 •
2017
Murine full-thickness skin transplantation is a well-established model to study rejection in an alloimmune setting. Here, we provide a tutorial of each step involved in performing a BALB/c-->C57BL/6 full-thickness skin transplant.
FAQs
Maintaining a tissue’s blood supply helps keep transferred cells viable during movement to the recipient site. When the original supply cannot be preserved, surgeons can reconnect blood vessels so circulation is restored. This vascular support promotes revascularization, the return of blood flow through the transferred tissue, and contributes to healing after placement.
Because the transferred tissue comes from the same person, the procedure avoids donor-recipient incompatibility. This substantially reduces the risk of immune rejection compared with situations involving tissue from another individual. That immunologic compatibility supports the use of autologous tissue for reconstruction or replacement when suitable tissue is available.
Successful healing depends on maintaining tissue viability, supporting circulation, and securing the graft at its new location. Preserving the blood supply when possible or reconnecting vessels when necessary helps provide the conditions for revascularization. Stable placement then allows the transferred tissue to heal as part of the recipient site.
The process begins with removal of viable tissue from a donor location within the same person. Surgeons then preserve its blood supply when feasible or reconnect vessels at the recipient site. Finally, they position and secure the tissue so that revascularization and healing can occur in the area requiring reconstruction or replacement.
Clinicians may consider this approach when a patient’s own viable tissue can repair an injury, restore function, or replace a damaged structure. The overview identifies skin, bone, and teeth among the transferred tissues. Accordingly, auto-transplantation has roles in reconstructive surgery, dentistry, and regenerative medicine, with the specific choice depending on the tissue needed.
Auto-transplantation can provide structural reconstruction, replacement of damaged tissue, or restoration of function. Its value extends beyond transferring tissue because the procedure combines viable autologous material with efforts to reestablish circulation and healing. In medicine, this makes it relevant to repairing injuries and addressing damaged structures in surgical, dental, and regenerative settings.