Localizer Images
Localizer Images - Related Videos
09:30
Imaging Local Ca2+ Signals in Cultured Mammalian Cells
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Cited by 17 •
2015
Here we present techniques for imaging local IP3-mediated Ca2+ events using fluorescence microscopy in intact mammalian cells loaded with Ca2+ indicators together with an algorithm that automates identification and analysis of these events.
09:57
How to Measure Cortical Folding from MR Images: a Step-by-Step Tutorial to Compute Local Gyrification Index
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Cited by 168 •
2012
Measuring gyrification (cortical folding) at any age represents a window into early brain development. Hence, we previously developed an algorithm to measure local gyrification at thousands of points over the hemisphere1. In this paper, we detail the computation of this local gyrification index.
13:08
Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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Cited by 17 •
2017
The precise localization of Golgi residents is essential for understanding the cellular functions of the Golgi. However, conventional optical microscopy is unable to resolve the sub-Golgi structure. Here we describe the protocol for a conventional microscopy based super-resolution method to quantitatively determine the sub-Golgi localization of a protein.
03:10
In Vivo Fluorescence Imaging to Localize Antibodies in a Mouse Tumor Xenograft Model
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2025
The video demonstrates a fluorescence imaging method for in vivo antibody localization in a mouse tumor xenograft model. It involves the injection of tumor cells in a mouse to generate solid xenografts beneath the skin. Subsequent injection of fluorescent antibodies confirms specific localization through enhanced fluorescence signals within the tumor xenograft.
09:29
Using Digital Image Correlation to Characterize Local Strains on Vascular Tissue Specimens
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Cited by 19 •
2016
We describe the use of digital image correlation to characterize the local surface strain field on vascular tissue samples subjected to uniaxial tensile testing. These measurements facilitate precise quantification of the sample mechanical response and the generation of constitutive stress-strain relations.
FAQs
In computed tomography, the localizer acts as a projection-based planning view rather than the detailed cross-sectional acquisition that follows. Its broad anatomical display allows the technologist to identify the relevant region and choose where subsequent slices should begin and end. This planning role helps align the detailed scan with the intended anatomy instead of relying on an arbitrary coverage range.
The main practical value is targeted coverage. By showing the patient's anatomy before detailed acquisition, a localizer helps limit imaging to the necessary region rather than extending the scan unnecessarily. In CT, this supports lower exposure when applicable, while across imaging workflows it can also reduce inefficient acquisition and promote more consistent examination setup.
Localizer images do not function identically across every modality. CT commonly obtains a low-dose projection for slice planning, whereas MRI and other modalities may use related planning images to establish the region and orientation of the examination. The shared principle is preparatory targeting, but the specific image type and acquisition context depend on the modality.
Patient position and scan geometry are closely connected. A localizer gives the technologist a visual reference for how the patient is situated and where the anatomy lies within the planned examination. That reference supports decisions about alignment, scan direction, and extent, helping the subsequent images represent the intended anatomy in a consistent manner.
During a typical workflow, the technologist first positions the patient and acquires the preliminary planning image. The image is then reviewed to identify the target anatomy, establish the examination range, and determine the direction of subsequent acquisition. Detailed scanning follows within that planned region. The sequence turns a rapid overview into concrete acquisition settings.
Review focuses on whether the intended anatomy is included and whether the planned range, alignment, and acquisition direction correspond to the examination. These checks use the patient's displayed anatomical position as the planning reference. Correct interpretation before detailed scanning can prevent coverage that is misplaced or broader than needed, supporting a usable and efficient study.
In medicine, localizer images are useful whenever a diagnostic study requires deliberate selection of an anatomical region before detailed acquisition. They support CT examinations directly through projection-based slice planning and provide analogous preparation in MRI and other modalities. Their contribution is operational as well as clinical: they help the examination focus on the requested anatomy while maintaining consistent image acquisition.