Older Adults Diabetes
Older Adults Diabetes - Related Videos
10:43
Transplantation of Pancreatic Islets Into the Kidney Capsule of Diabetic Mice
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Cited by 98 •
2007
Our protocol was developed to cleanly and easily deliver islets or cells under the kidney capsule of mice. Cells are concentrated into pellets in the final tubing used for transplanting the cells under the kidney capsule. The ease of this technique reduces stress to the cells and the mouse.
16:26
Regulatory T cells: Therapeutic Potential for Treating Transplant Rejection and Type I Diabetes
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Cited by 2 •
2007
05:45
Rapid Determination of the Thermal Nociceptive Threshold in Diabetic Rats
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Cited by 10 •
2012
Here, we describe a rapid reliable and simple procedure to determine the lowest temperature at which rats or mice show nocifensive behavior, i.e. the thermal nociceptive threshold (TNT). This method applies a slowly increasing thermal stimulus allowing precise and reproducible estimation of TNTs with minimum, if any, stress to the animals.
16:59
Neo-Islet Formation in Liver of Diabetic Mice by Helper-dependent Adenoviral Vector-Mediated Gene Transfer
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Cited by 5 •
2012
We describe hepatic neo-islet formation in STZ (streptozotocin)-induced diabetic mice by gene transfer of Neurogenin3 (Ngn3) and Betacellulin (Btc) using helper-dependent adenoviral vector (HDAd) and the reversal of hyperglycemia. Our method takes advantages of helper-dependent adenoviral vectors with their highly efficient in vivo transduction and the long lasting gene expression.
10:03
A Zebrafish Model of Diabetes Mellitus and Metabolic Memory
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Cited by 69 •
2013
Metabolic memory is the phenomenon by which diabetic complications persist and progress unimpeded even after euglycemia is achieved pharmaceutically. Here we describe a diabetes mellitus zebrafish model which is unique in that it allows for the examination of the mitotically transmissible epigenetic components of metabolic memory in vivo.
FAQs
Age-related changes do not act alone. Multiple illnesses and medications can complicate glucose regulation, making a single treatment approach less suitable across all older patients. Clinicians must consider how these interacting factors affect cardiovascular, kidney, nerve, eye, and functional health when choosing targets and adjusting care. This supports individualized decisions rather than relying only on age-based assumptions.
Treatment goals should be individualized instead of applied uniformly. Care planning accounts for overall health, cognition, mobility, independence, and the need to prevent hypoglycemia. These considerations help clinicians balance glucose control with treatment safety and daily functioning. The result is a plan aligned with the person's health status and ability to manage care, rather than a target chosen in isolation.
These factors influence how safely a person can follow a care plan and respond to changing health needs. A clinically appropriate strategy must therefore consider more than blood glucose alone. Incorporating cognition, mobility, and independence helps connect medication selection, glucose monitoring, nutrition, and activity recommendations with the person's functional circumstances and supports safer clinical decisions.
A comprehensive plan combines nutrition, physical activity, medication selection, glucose monitoring, and prevention of hypoglycemia. These elements should be coordinated with individualized glucose targets and the person's overall health, cognition, mobility, and independence. Considering the components together helps clinicians create care that is practical for daily life while addressing both glucose regulation and treatment safety.
Glucose monitoring is one component of an individualized management strategy, not a substitute for clinical judgment. Its role should be considered alongside nutrition, physical activity, medication selection, glucose targets, and hypoglycemia prevention. When integrated into the broader care plan, monitoring supports safer treatment decisions and helps clinicians account for the person's overall health and functional circumstances.
Clinical attention should include cardiovascular, kidney, nerve, and eye health, along with functional status. Early recognition of problems in these areas can support timely care decisions and reduce the chance that treatment overlooks daily capabilities or independence. Management is therefore directed not only toward glucose values, but also toward preserving health and function across multiple affected systems.