Systolic Function
Systolic Function - Related Videos
07:13
A Rat Model of Pressure Overload Induced Moderate Remodeling and Systolic Dysfunction as Opposed to Overt Systolic Heart Failure
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Cited by 1 •
2020
We describe the creation of a rat model of pressure overload induced moderate remodeling and early systolic dysfunction where signal transduction pathways involved in the initiation of the remodeling process are activated. This animal model will aid in identifying molecular targets for applying early therapeutic anti-remodeling strategies for heart failure.
10:20
Right Ventricular Systolic Pressure Measurements in Combination with Harvest of Lung and Immune Tissue Samples in Mice
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Cited by 17 •
2013
A specific and rapid protocol to simultaneously investigate right heart function, lung inflammation, and the immune response is described as a learning tool. Video and figures describe physiology and microdissection techniques in an organized team-approach that is adaptable to be used for small to large sized studies.
11:35
Dual-mode Imaging of Cutaneous Tissue Oxygenation and Vascular Function
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Cited by 16 •
2010
A dual-mode imaging system was developed for non-contact assessment of cutaneous tissue oxygenation and vascular function.
05:41
Non-invasive Assessment of Microvascular and Endothelial Function
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Cited by 12 •
2013
Capillaroscopy is a non-invasive, relatively inexpensive methodology for directly visualizing the microcirculation. The forearm blood flow technique provides accepted non-invasive measures of endothelial function.
04:11
Functional Cardiac Imaging in Zebrafish Embryos Using Standard Microscopy and Video Analysis: Applications in Environmental and Biomedical Research
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2025
This protocol describes a low-cost light microscopy method to assess cardiac morphology and function in zebrafish embryos, enabling reproducible evaluation of developmental cardiotoxicity without the need for advanced imaging systems.
FAQs
Electrical activation initiates myocardial contraction, which raises pressure inside the ventricles. Ejection begins when ventricular pressure becomes greater than the pressure in the connected arteries, allowing blood to pass through the semilunar valves. This pressure-dependent sequence links cardiac electrical activity with forward flow into the pulmonary and systemic circulations and provides the mechanical basis for assessing ventricular performance.
Ventricular pressure must exceed arterial pressure before blood can be driven through the semilunar valves. This relationship determines when ejection occurs during systole and helps explain how ventricular contraction produces forward circulation. Because systolic performance depends on generating sufficient pressure for ejection, changes in measured function can provide clinically relevant information about cardiac performance.
Stroke volume and ejection fraction are quantitative measures used to characterize ventricular performance. They provide complementary numerical descriptions of how effectively the heart ejects blood during systole rather than relying only on the presence of contraction. In clinical assessment, these measures support the evaluation and classification of cardiac dysfunction, including heart failure and cardiomyopathies.
Abnormal measurements may contribute to the assessment of heart failure, ischemic injury, and cardiomyopathies. The findings help clinicians evaluate how disease affects ventricular performance and support classification of the resulting cardiac condition. This makes systolic assessment relevant not only to identifying impaired function, but also to organizing the clinical understanding of several major cardiovascular disorders.
Assessment can use echocardiography, cardiac magnetic resonance imaging, or other cardiac tests. These approaches provide measurements or evaluations of ventricular performance, including measures such as stroke volume and ejection fraction. The selected assessment supports clinical interpretation of systolic function and can be repeated when clinicians need to follow disease progression or evaluate response to management.
Measurement is useful when clinicians are diagnosing or classifying heart failure, evaluating ischemic injury, or investigating cardiomyopathies. It also supports treatment decisions, monitoring over time, and estimation of cardiovascular risk. Because the same assessment can inform diagnosis, follow-up, and management, systolic function serves as an important link between cardiac testing and clinical decision-making.