Venous Bypass Graft
Venous Bypass Graft - Related Videos
08:08
Cardiopulmonary Bypass in a Mouse Model: A Novel Approach
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Cited by 9 •
2017
This paper describes how to perform cardiopulmonary bypass in mice. This novel model will facilitate the investigation of the molecular mechanisms involved in organ damage.
12:49
Porcine Liver Transplantation Without Veno-Venous Bypass As an Extended Criteria Donor Model
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Cited by 2 •
2022
In this protocol, a model of porcine orthotopic liver transplantation after static cold storage of donor organs for 20 h without the use of a veno-venous bypass during engraftment is described. The approach uses a simplified surgical technique with minimization of the anhepatic phase and sophisticated volume and vasopressor management.
08:12
Normothermic Ex Vivo Kidney Perfusion for the Preservation of Kidney Grafts prior to Transplantation
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Cited by 43 •
2015
The severe organ shortage has resulted in increased use of marginal kidney grafts for transplantation. This has triggered interest in alternative storage methods, since marginal grafts especially tolerate cold storage poorly. The technique of normothermic ex vivo kidney perfusion (NEVKP) represents a novel preservation method for kidney grafts prior to transplantation.
07:22
Vein Interposition Model: A Suitable Model to Study Bypass Graft Patency
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Cited by 3 •
2017
This video demonstrates a model to study the development of myointimal hyperplasia after venous interposition surgery in rats.
15:21
Training a Sophisticated Microsurgical Technique: Interposition of External Jugular Vein Graft in the Common Carotid Artery in Rats
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Cited by 9 •
2012
Neointimal hyperplasia is the primary cause of stenosis in arterialized veins. We propose a new protocol whereby the right external jugular vein is grafted using the cuff technique in the common carotid artery of Sprague Dawley rats. The survival rate was 100 % at the time point of sacrifice.
FAQs
Preparation adapts the harvested venous segment for its new role in an arterial circuit. In coronary and peripheral procedures, surgeons commonly use the saphenous vein and either reverse it or otherwise prepare it before creating the bypass. This step helps make the conduit suitable for blood flow between the selected arterial connection points.
Long-term function depends on graft patency, meaning continued openness for blood passage. Thrombosis can obstruct the conduit, while atherosclerosis and intimal hyperplasia can progressively compromise it. These processes explain why an initially successful reconstruction may later fail and why durability is a central outcome when evaluating revascularization.
Patency allows blood to continue reaching tissues beyond the original obstruction through the surgically created route. If the graft remains open, restored circulation can help address ischemia, the inadequate blood supply associated with narrowing or blockage. Maintaining this pathway therefore supports the intended reduction in symptoms and tissue injury.
The procedure begins with harvesting a suitable vein, commonly the saphenous vein. Surgeons then reverse or otherwise prepare the segment for arterial flow and connect it above and below the diseased arterial region. These connections establish an alternate route through which blood can pass around the obstructed segment.
Two important applications are coronary artery bypass and lower-limb revascularization. In both settings, the graft provides a route around diseased arterial tissue, but the treated circulation differs: one involves blood supply to the heart, while the other addresses circulation in the lower extremity. The shared clinical goal is treatment of ischemia.
Successful revascularization can restore circulation beyond an arterial obstruction, helping treat ischemia and reduce associated symptoms or tissue injury. Clinicians also consider graft patency as a major long-term outcome because the benefits depend on the bypass remaining open. Later thrombosis, atherosclerosis, or intimal hyperplasia can reduce that benefit.