Double-cone Coil

A double-cone coil is a transcranial magnetic stimulation (TMS) device designed to stimulate brain regions that lie deeper beneath the scalp, making it valuable for neuroscience research and noninvasive brain modulation. When a brief, high-current pulse passes through its two angled windings, the resulting magnetic field induces electrical currents in underlying cortical tissue; the coil’s geometry supports deeper penetration than many conventional focal coils, although with reduced spatial precision. Researchers use double-cone coils to study motor pathways, evoke responses from leg-related cortical areas, and investigate how brain stimulation influences neural circuits, behavior, and neurological function.

Double-cone Coil - Related Videos

Research

JoVE Journal - Medicine
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Transperineal Prostate Biopsy Using a Cone-shaped Double-hole Method with Dual-plane Probe Guidance

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2025

This study presents an enhanced transperineal prostate biopsy technique using a cone-shaped double-hole method and dual-plane probe guidance. These modifications reduce trauma, enhance patient recovery, and improve biopsy accuracy, making the procedure a reliable and minimally invasive approach for prostate cancer diagnosis.

Research

JoVE Journal - Biochemistry

Combining Wet and Dry Lab Techniques to Guide the Crystallization of Large Coiled-coil Containing Proteins

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Cited by 2 •

2017

We describe a framework incorporating straightforward biochemical and computational analysis to guide the characterization and crystallization of large coiled-coil domains. This framework can be adapted for globular proteins or extended to incorporate a variety of high-throughput techniques.

Research

JoVE Journal - Behavior
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How to Use the H1 Deep Transcranial Magnetic Stimulation Coil for Conditions Other than Depression

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Cited by 13 •

2017

The H1 deep transcranial magnetic stimulation coil is FDA-cleared for the treatment of depression. We demonstrate how to utilize the H1 for other conditions, such as auditory hallucinations and PTSD, by moving the helmet to different locations over the subject's skull.

Single-cell Suction Recordings from Mouse Cone Photoreceptors

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Cited by 9 •

2010

We will show how to record flash responses from single mouse cones using a suction electrode.

Labeling F-actin Barbed Ends with Rhodamine-actin in Permeabilized Neuronal Growth Cones

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Cited by 10 •

2011

A method to visualize and quantify F-actin barbed ends in neuronal growth cones is described. After culturing neurons on glass coverslips, cells are permeabilized with a saponin-containing solution. Then, a short incubation with the saponin buffer containing rhodamine-actin incorporates fluorescent actin onto free actin barbed ends.

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