Mouse Vno
Mouse Vno - Related Videos
04:48
Preparation of Mouse Vomeronasal Organ for Vibratome Sectioning
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2025
This video outlines the isolation of a mouse vomeronasal organ (VNO) and tissue preparation for vibratome sectioning. Sections are used to characterize the biophysical and physiological attributes of a specific group of sensory neurons.
09:31
Imaging Pheromone Sensing in a Mouse Vomeronasal Acute Tissue Slice Preparation
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Cited by 15 •
2011
In mice, the ability to detect pheromones is principally mediated by the vomeronasal organ (VNO). Here, an acute tissue slice preparation of VNO for performing calcium imaging is described. This physiological approach allows observations of subpopulations and/or individual neurons in a living tissue and is convenient for receptor-ligand identification.
10:11
In-depth Physiological Analysis of Defined Cell Populations in Acute Tissue Slices of the Mouse Vomeronasal Organ
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Cited by 1 •
2016
Here, we describe a physiological approach that allows identification and in-depth analysis of a defined population of sensory neurons in acute coronal tissue slices of the mouse vomeronasal organ using whole-cell patch-clamp recordings.
09:08
Multiple-mouse Neuroanatomical Magnetic Resonance Imaging
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Cited by 59 •
2011
Magnetic resonance imaging (MRI) has become an increasingly popular tool for examining the phenotype of genetically altered mice. This article illustrates the methods necessary to achieve high-throughput phenotyping of genetically altered mice using multiple-mouse MRI.
07:04
A Novel Use of Three-dimensional High-frequency Ultrasonography for Early Pregnancy Characterization in the Mouse
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Cited by 5 •
2017
Mice are widely used to study gestational biology. However, pregnancy termination is required for such studies which precludes longitudinal investigations and necessitates the use of large numbers of animals. Therefore, we describe a non-invasive technique of high-frequency ultrasonography for early detection and monitoring of post-implantation events in the pregnant mouse.
FAQs
Vomeronasal receptors recognize nonvolatile chemical compounds and convert that detection into intracellular signaling in sensory neurons. These pathways include activation of the TRPC2 ion channel, linking receptor stimulation to electrical activity. The resulting neural information travels to the accessory olfactory bulb, providing a route for chemical cues to influence downstream brain circuits and behavior.
TRPC2 is important because it forms part of the signaling pathway that connects chemical detection with neuronal activation. Examining this channel helps researchers relate receptor stimulation to the transmission of vomeronasal information. In neuroscience, that link is useful for investigating how molecular events in sensory neurons contribute to social and reproductive behaviors.
The accessory olfactory bulb serves as an early neural destination for information from vomeronasal sensory neurons. Its position in the pathway allows researchers to examine how chemical signals are organized after detection and before influencing broader brain function. Studying this connection helps clarify sensory circuit organization underlying behaviors such as mating and aggression.
Research using the mouse VNO can address how chemical cues influence mating, aggression, and other sex-specific social behaviors. These behavioral outcomes provide functional readouts for studying pheromone detection and neural communication. Comparing responses across such contexts helps connect activity in vomeronasal pathways with distinct behavioral programs rather than treating chemical sensing as an isolated sensory event.
Researchers use the mouse VNO as a model for examining how pheromone-related chemical cues are detected and transmitted through defined neural pathways. The system connects vomeronasal receptors, TRPC2-associated signaling, and the accessory olfactory bulb with observable social or reproductive behaviors. This organization supports studies that relate molecular detection to behavioral outcomes.
Its accessible anatomy and defined genetic pathways make the mouse VNO a practical system for linking sensory structures, molecular signaling, neural circuits, and behavior. Investigators can use this organization to study how chemical communication affects brain function, while behavioral analyses provide context for interpreting changes in pheromone detection, mating, aggression, or sex-specific responses.