Noninvasive Brain Modulation
Noninvasive Brain Modulation - Related Videos
09:31
Noninvasive Blood Pressure Measurement Techniques
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2023
Source: Hamna J. Qureshi and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana Here we will highlight the key similarities and differences of noninvasive blood pressure measurement techniques between humans and rodents and examine the engineering principles that govern blood pressure. The principles that govern current cuff technology to acquire systolic and diastolic pressures will also be discussed. Commercially available cuffs that connect...
03:34
Histochemical Imaging of Cortical Modules in Flattened Brain Sections
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2025
Source: Lauer, S. M., et al. Visualization of Cortical Modules in Flattened Mammalian Cortices. J. Vis. Exp. (2018) This video demonstrates a method to visualize the cortical modules in flattened brain sections using histochemical staining. Pre-fixed sections are treated with a straining reagent that highlights active neural clusters, forming dark, high-contrast regions. After mounting and dehydration, cortical modules appear under a bright-field microscope as dark, patchy patterns.
07:47
Non-Invasive Electrical Brain Stimulation Montages for Modulation of Human Motor Function
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Cited by 4 •
2016
Non-invasive electrical brain stimulation can modulate cortical function and behavior, both for research and clinical purposes. This protocol describes different brain stimulation approaches for modulation of the human motor system.
02:37
Ophthalmic Drug Delivery for Noninvasive Neuromodulation in a Mouse Model
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2025
Source: Zhan, J., et al. Non-invasive Strategies for Chronic Manipulation of DREADD-controlled Neuronal Activity. J. Vis. Exp. (2019)This video demonstrates a non-invasive ophthalmic drug delivery method for targeted neuromodulation. The drug is delivered via eye drops, absorbed into the circulation, crosses the blood-brain barrier, and activates specific neuronal receptors.
06:45
Integrated Photoacoustic, Ultrasound, and Angiographic Tomography (PAUSAT) for NonInvasive Whole-Brain Imaging of Ischemic Stroke
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Cited by 4 •
2023
This work demonstrates the use of a multimodal ultrasound-based imaging platform for noninvasive imaging of ischemic stroke. This system allows for the quantification of blood oxygenation through photoacoustic imaging and impaired perfusion in the brain through acoustic angiography.
FAQs
The two principal examples act through different physical inputs. TMS uses changing magnetic fields to induce electrical currents in cortical tissue, whereas tDCS applies weak electrical current through electrodes on the scalp. This distinction matters because the stimulation route is part of how researchers interpret changes in neuronal excitability and network activity.
Stimulation parameters shape outcomes by influencing neuronal excitability and network activity. Researchers therefore consider the settings used when interpreting whether a change reflects altered activity in a targeted cortical area, broader network effects, or both. This parameter-dependent behavior is important for comparing experiments and for evaluating how consistently a technique affects brain function.
Noninvasive brain modulation can support causal tests because researchers can alter neural activity and examine resulting behavioral or functional changes, rather than only measure naturally occurring activity. Its reversibility also allows investigators to assess effects without permanent intervention, which is useful when studying brain function or evaluating a potential treatment across repeated sessions.
A neuroscience study can pair a stimulation method with measurements of brain function or behavior. Investigators select either magnetic stimulation or scalp-electrode current, set the relevant stimulation parameters, apply the intervention, and examine the resulting changes. This workflow connects a deliberate change in neural activity with an observed outcome, supporting tests of brain-behavior relationships.
Therapeutic investigations apply these approaches to conditions named in the overview, including depression, pain, and movement disorders. The goal is not only to observe neural effects but also to evaluate whether changing activity can contribute to treatment development. Because the techniques do not require surgery or implanted devices, they can be considered in studies that involve repeated experimental or clinical use.
Compared with approaches that require surgery or implanted devices, noninvasive brain modulation avoids those interventions while retaining the ability to alter neural activity. Its reversibility and relatively low burden make it suitable for repeated experimental or clinical use. This distinction is especially relevant when researchers need to study changing effects or evaluate an intervention over multiple sessions.