Gastric Lavage

Gastric lavage is a decontamination procedure that removes stomach contents through tube irrigation and is relevant to pharmacology because it can limit absorption after selected oral poisonings or drug overdoses. A large-bore orogastric tube is positioned in the stomach, contents are aspirated, and repeated aliquots of fluid are instilled and withdrawn until the return is relatively clear. Its effectiveness depends on the substance, timing, dose, and gastric retention, while airway protection is essential when consciousness is impaired because aspiration can cause serious complications. In modern toxicology, clinicians use gastric lavage selectively rather than routinely, weighing benefits against risks and considering alternatives such as activated charcoal and supportive care.

Gastric Lavage - Related Videos

Research

JoVE Journal - Medicine
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Bronchoalveolar Lavage (BAL) for Research; Obtaining Adequate Sample Yield

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Cited by 47 •

2014

We describe a research technique for fiberoptic bronchoscopy and bronchoalveolar lavage using low pressure suction. The technique is used to harvest immune cells from the lung bronchoalveolar surfaces. Local anesthetic and mild conscious sedation (midazolam) is used. Subjects tolerate the procedure well and experience minimal side effects.

Research

JoVE EoE - Rodent Models

Roux-en-Y Gastric Bypass Procedure: A Bariatric Surgical Procedure for Gastric Resectioning in Murine Model

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2025

This video describes a bariatric surgery-Roux-en-Y procedure. This involves the cutting of the jejunum- the middle portion of the intestine- to generate two intestinal limbs. The biliary limb is attached to the existing intestinal loop and the alimentary limb is attached to the stomach, creating a gastric bypass. The gastric bypass created here helps to decrease the nutrient uptake and efficiently reduces body weight.

Roux-en-Y Gastric Bypass Operation in Rats

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Cited by 45 •

2012

Numerous studies using gastric bypass rat models have been recently conducted to uncover the underlying physiological mechanisms of Roux-en-Y gastric bypass operations. This article aims to demonstrate and discuss the technical and experimental details of our published gastric bypass rat model to understand advantages and limitations of this experimental tool.

Bronchoalveolar Lavage of Murine Lungs to Analyze Inflammatory Cell Infiltration

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Cited by 155 •

2017

The health status of the lung is reflected by the type and number of immune cells that are present in the bronchioles of the lung. We describe a bronchoalveolar lavage technique that allows the isolation and study of nonadherent cells and soluble factors from the lower respiratory tract of mice.

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

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2025

Laparoscopic radical gastrectomy for remnant gastric cancer has been increasingly adopted as a minimally invasive surgical approach in recent years. This article proposes a detailed operating procedure, aiming to provide practical technical guidance for surgeons and promote the broader adoption of laparoscopic surgery in managing remnant gastric cancer.

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