Emphysema Model
Emphysema Model - Related Videos
01:23
Chronic Obstructive Pulmonary Disease II: Emphysema
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2026
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
05:48
Lung Fixation under Constant Pressure for Evaluation of Emphysema in Mice
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Cited by 4 •
2019
Presented here is a useful protocol for lung fixation that creates a stable condition for histological evaluate of lung specimens from a mouse model of emphysema. The main advantage of this model is that it can fix many lungs with the same constant pressure without lung collapse or deflation.
10:37
Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
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Cited by 38 •
2015
The goal of this protocol is to provide automated methods to quantify chronic lung pathologies in a murine model of COPD. The protocol includes exposing mice to cigarette smoke (CS), measuring pulmonary function, inflating the lungs, and using morphometry methods to measure emphysema and small airway remodeling in mice.
08:17
Generation of a Chronic Obstructive Pulmonary Disease Model in Mice by Repeated Ozone Exposure
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Cited by 7 •
2017
This study describes the successful generation of a new chronic obstructive pulmonary disease (COPD) animal model by repeatedly exposing mice to high concentrations of ozone.
12:31
In Vivo Modeling of the Morbid Human Genome using Danio rerio
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Cited by 66 •
2013
Here, we present a systematic approach for developing physiologically relevant, sensitive and specific in vivo assays for interpreting variation in human pathology. Transient genetic manipulation via microinjection of WT and mutant human mRNA and morpholino (MO) antisense oligonucleotides harness the tractability of the developing zebrafish embryo to rapidly assay pathogenic mutations, especially, but not exclusively, in the context of human developmental disorders.
FAQs
Reduced elastic recoil provides less restoring force to drive air out during exhalation. In a physics-based representation, this change alters the relationship between lung pressure and volume, so a given pressure condition may produce less effective emptying. Modeling recoil separately from airway resistance helps researchers examine how tissue damage contributes to impaired airflow and changes in breathing mechanics.
Increased airspace represents a structural change that modifies how damaged lung regions occupy volume and participate in ventilation. When combined with alveolar damage, it can produce spatial differences in mechanical behavior across the model. Examining these changes allows researchers to connect altered tissue structure with regional ventilation patterns rather than interpreting lung function as uniform throughout the organ.
Pressure, volume, and airflow provide complementary measures of respiratory mechanics. The model uses their relationships to represent how lung regions expand, recoil, and move air during breathing. Changes in alveolar structure, elastic recoil, or airway resistance can therefore be evaluated through predicted shifts in these variables, helping explain why damaged regions contribute differently to overall ventilation.
A model can represent alveolar damage, enlarged airspace, reduced elastic recoil, and altered airway resistance as separate but interacting features. These components translate structural abnormalities into mechanical behavior that can be analyzed quantitatively. Selecting the relevant components allows a study to focus on tissue mechanics, airflow, regional ventilation, or the links among all three.
Researchers can compare model behavior with structural information from imaging and mechanical measurements from pulmonary function data. Imaging helps relate regional damage and airspace changes to the modeled lung structure, while pressure, volume, and airflow measurements test the mechanical response. This combined approach supports a more quantitative interpretation than either structural or functional data alone.
A physics-based model is useful when researchers need to examine how a potential intervention could affect breathing mechanics without relying solely on measurements from patients. By changing represented features such as airway resistance, elastic recoil, or damaged-region behavior, investigators can assess predicted effects on pressure, volume, airflow, and ventilation before interpreting those effects in a broader research context.