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Cancer Research

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JoVE Journal Cancer Research

Lentiviral Infection of MPNST Cells and Genomic DNA Isolation for Genome-Scale shRNA Screens (Video) | JoVE

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

Journal (Cancer Research)

Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers

ATAC-Seq Optimization for Cancer Epigenetics Research

Journal (Cancer Research)

ATAC-Seq Optimization for Cancer Epigenetics Research

Lentiviral Infection of MPNST Cells and Genomic DNA Isolation for Genome-Scale shRNA Screens (Video) | JoVE

Genome-Scale Screening to Identify and Compare Therapeutic Targets in Tumors

Article DOI: 10.3791/200478-v • 03:50 min • August 25th, 2023

August 25th, 2023 •

Brittany Turner-Ivey¹, Jody Fromm Longo², Dorea P. Jenkins², Stephen T. Guest³, Steven L. Carroll^1,2

¹Hollings Cancer Center, Medical University of South Carolina, ²Department of Pathology and Laboratory Medicine, Medical University of South Carolina, ³Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor

Tags

Genetic Profiling Genome-scale Dropout Screening Therapeutic Targets Mouse Models Malignant Peripheral Nerve Sheath Tumor Schwann Cells Neurofibromatosis Type 1 (NF1) Soft-tissue Sarcoma Disease-free Survival Rates Treatment Options Disfiguring Surgery Tipifarnib Ras Signaling Inhibitor Erlotinib Epidermal Growth Factor (EGFR) Inhibitor Sorafenib Vascular Endothelial Growth Factor Receptor (VEGF) Inhibitor Platelet-derived Growth Factor Receptor (PDGF) Inhibitor Raf Inhibitor Functional Genomic Screening Cancer Cell Lines Cytoplasmic Signaling Pathways Target-specific Therapies

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