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Journal / Bioengineering / 리빙 셀의 Subcellular 수준과 초 Timescale에 작은 GTPase 활동의…
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Bioengineering

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리빙 셀의 Subcellular 수준과 초 Timescale에 작은 GTPase 활동의 Spatio-시간적 조작
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리빙 셀의 Subcellular 수준과 초 Timescale에 작은 GTPase 활동의 Spatio-시간적 조작

Article DOI: 10.3791/3794-v • 10:28 min • March 9th, 2012
March 9th, 2012 •
1, 1, 1,2, 1,2, 2, 1,3, 1
1Department of Cell Biology, Center for Cell Dynamics, Johns Hopkins University, 2Graduate School of Pharmaceutical Sciences, University of Tokyo, 3Biomedical Engineering, Johns Hopkins University

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빛으로 작은 GTPase 활동 spatio-시간적 제어를위한 방법을 설명합니다. 이 방법은 rapamycin-유도 FKBP-FRB의 heterodimerization 및 사진 caging 시스템을 기반으로합니다. 빛을 조사의 최적화는 subcellular 수준에서 작은 GTPases의 spatio-temporally 제어 활성화를 가능하게합니다.

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생물 이슈 61 소형 GTPase rapamycin 갇힌 화합물 spatiotemporal 제어 heterodimerization FKBP FRB 라이트 방사선
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