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Journal / Immunology and Infection / Använda BLT Humaniserad Pigg som en stamcell…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Använda BLT Humaniserad Pigg som en stamcell baserad genterapi tumörmodell
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Använda BLT Humaniserad Pigg som en stamcell baserad genterapi tumörmodell

Article DOI: 10.3791/4181-v • 06:59 min • December 18th, 2012
December 18th, 2012 •
1,2,3, 1,2, 1,2, 1,2, 4, 4, 1,2,3, 1,2,5
1Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology, David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA

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Alstringen och karakterisering av tumörspecifika T-celler med användning av humaniserade möss beskrivs här. Human tymusvävnad och genetiskt modifierade humana hematopoetiska stamceller transplanteras till nedsatt immunförsvar möss. Detta resulterar i att rekonstituera en manipulerad mänskliga immunsystemet möjliggör in vivo-undersökning av anti-tumör immunsvar.

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Cancer Biology Stem Cell Biology immunologi medicinsk teknik medicin bioteknik genetik onkologi humaniserade möss stamcellstransplantation stamceller, T-celler cancer djurmodell
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