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The Rabbit Blood-shunt Model for the Study of Acute and Late Sequelae of Subarachnoid Hemorrhage: Technical Aspects

Article DOI: 10.3791/52132-v • 09:00 min • October 2nd, 2014
October 2nd, 2014 •
3,4,5, 1,6, 7, 5, 1, 1, 1,2, 1,2
1Department of Intensive Care Medicine, University and Bern University Hospital (Inselspital), 2Department of Neurosurgery, Kantonsspital Aarau, 3Laboratories for Neuroscience Research in Neurosurgery, Boston Children's Hospital, 4Harvard Medical School, Boston Children's Hospital, 5Department of Neurosurgery, University and Bern University Hospital (Inselspital), 6Department of Neurosurgery, University Hospital Cologne, 7Institute of Pathology, Länggasse Bern

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Summary
Automatic Translation

The experimental intracranial pressure-controlled blood shunt subarachnoid hemorrhage (SAH) model in the rabbit combines the standard procedures — subclavian artery cannulation and transcutaneous cisterna magna puncture, which enables close mimicking of human pathophysiological conditions after SAH. We present step-by-step instructions and discuss key surgical points for successful experimental SAH creation.

Tags

Rabbit Blood-shunt Model Subarachnoid Hemorrhage Acute Sequelae Late Sequelae Technical Aspects Brain Injury Cerebral Vasospasm Animal Models Pathophysiological Conditions Intracerebral Pressure (ICP) Extracorporeal Shunt Examiner-independent SAH Closed Cranium Procedural Instructions Necessary Equipment Minimal Mortality Minimal Morbidity Surgical Creation
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