Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Matthias Ernst; Adele Preaudet; Tracy Putoczki

doi:10.3791/52383

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Nicht-invasive Beurteilung der Wirksamkeit neuer Therapeutika für Darmpathologien Verwenden der seriellen endoskopische Bildgebung von lebenden Mäusen

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

JoVE Journal
Medizin

This content is Free Access.

JoVE Journal Medizin

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Nicht-invasive Beurteilung der Wirksamkeit neuer Therapeutika für Darmpathologien Verwenden der seriellen endoskopische Bildgebung von lebenden Mäusen

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9,952 Views

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09:01 min

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March 10, 2015

DOI:

10.3791/52383-v

DOI:

10.3791/52383-v

•

09:01 min

March 10, 2015

•

6 Views

Matthias Ernst^1,2,3, Adele Preaudet¹, Tracy Putoczki^1,2

¹The Walter and Eliza Hall Institute for Medical Research, ²The Department of Medical Biology,University of Melbourne, ³Olivia Newton-John Cancer Research Institute

Summary

We describe methods for longitudinal monitoring of the efficacy of therapeutics for the treatment of colonic pathologies in mice using a rigid endoscope. This protocol can be readily used for the characterization of the therapeutic response of an individual tumor in live mice and also for monitoring potential disease relapse.