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Biochemistry

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JoVE Journal Biochemistry
Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling
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Formation of Covalent DNA Adducts by Enzymatically Activated Carcinogens and Drugs In Vitro and Their Determination by 32P-postlabeling

Article DOI: 10.3791/57177-v • 09:33 min • March 20th, 2018
March 20th, 2018 •
1
1Department of Biochemistry, Charles University

Kapitel

Summary
Automatic Translation

Evaluating the potency of environmental chemicals and drugs, to be enzymatically bioactivated to intermediates generating covalent DNA adducts, is an important field in the development of cancer and its treatment. Methods are described for compound activation to form DNA adducts, as well as techniques for their detection and quantification.

Tags

Covalent DNA Adducts Enzymatically Activated Carcinogens Drugs 32P-postlabeling Cytochrome P450 Biotransformation Enzymes Cancer Development Environmental Chemicals Carcinogenic Potency Initiation Of Cancer Development Molecular Mechanisms DNA Damage Oral Studies Enzymatic Activation Toxification Of Chemicals Incubation Mixture
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