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Journal / Developmental Biology / 促纤维化信号增强因子介导的小鼠胚胎成纤维细胞再编程诱导心肌细胞的抑制…
JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology
促纤维化信号增强因子介导的小鼠胚胎成纤维细胞再编程诱导心肌细胞的抑制
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促纤维化信号增强因子介导的小鼠胚胎成纤维细胞再编程诱导心肌细胞的抑制

Article DOI: 10.3791/57687-v • 09:16 min • June 3rd, 2018
June 3rd, 2018 •
1, 1, 1, 1, 2, 1
1Division of Cardiology, Department of Medicine, University of Colorado Anschutz Medical Campus, 2Department of Population Health Sciences, Medical College of Georgia, Augusta University

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通过 GATA4、Hand2、Mef2c、Tbx5、miR-1 和 miR-133 (GHMT2m) 的过度表达和 TGF β信号的抑制, 我们提出了一种健壮的方法, 将原发成纤维细胞重新编程成功能性心肌细胞。我们的协议在7天后的转导中产生跳动的心肌细胞, 效率高达60%。

Tags

发育生物学 问题 136 心脏重编程 转录因子 microRNAs 亲纤维化信号 复方 TGF β受体1抑制剂
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