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Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Article DOI: 10.3791/58194-v • 10:09 min • January 7th, 2019
January 7th, 2019 •
1, 1, 1
1Cancer Blood Disease Institute, Divisions of Experimental Hematology and Cancer Pathology, Cincinnati Children's Hospital Medical Center

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Summary
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Here, we describe protocols for the genetic and chemical validation of c-Fos and Dusp1 as a drug target in leukemia using in vitro and in vivo genetic and humanized mouse models. This method can be applied to any target for genetic validation and therapeutic development.

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C-Fos Dusp1 Oncogene Dependence Cancer Therapeutics Key Genes Kinase Driven Cancers Tumor Types Leukemia Solid Tumors Lung Cancer Brain Tumors Pancreatic Tumors Molecular Biology Cellular Physiology Leg Bones Scalpel Cell Suspension 70 Micrometer Cell Strainer 50 Milliliter Screw Cap Tube 10 Milliliter Pipette Bone Marrow Supernatant Vacuum Glass Pipette Poly-sucrose Centrifugation Total Mono
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