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Journal / Cancer Research / 患者衍生的胰腺癌异质异种移植模型,使用斑马鱼幼虫作为比较药物评估的宿主…
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Cancer Research

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JoVE Journal Cancer Research
患者衍生的胰腺癌异质异种移植模型,使用斑马鱼幼虫作为比较药物评估的宿主
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患者衍生的胰腺癌异质异种移植模型,使用斑马鱼幼虫作为比较药物评估的宿主

Article DOI: 10.3791/59507-v • 09:56 min • April 30th, 2019
April 30th, 2019 •
*1, *2,3, *1, 2,3, 1, 1, 2,3, 2,4,5,6, 1
1Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, 2National Human Genetic Resources Sharing Service Platform (2005DKA21300), 3Fudan University Shanghai Cancer Center, 4Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, 5Department of Oncology, Shanghai Medical College, Fudan University, 6Pancreatic Cancer Institute, Fudan University
* These authors contributed equally

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Summary
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该协议描述了基于病毒的双荧光标记肿瘤异种移植模型中的优化过程,使用幼虫斑马鱼作为宿主。这种异质异种异种移植模型模仿胰腺癌在体内微环境的组织组成,并作为在个性化zPDX(斑马鱼患者衍生异种移植)模型中评估药物反应的更精确的工具。

Tags

癌症研究 问题 146 癌症研究 肿瘤异种移植 斑马鱼 胰腺癌 体内药物评估 BCL2L1
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