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En orthotopic Resectional Mouse Model af kræft i bugspytkirtlen

Article DOI: 10.3791/61726-v • 07:17 min • September 24th, 2020
September 24th, 2020 •
1,2,4,5, 1,2, 1,2, 1,2, 3, 1, 1,2, 1,2, 1,2
1Pancreatic Research Group, South Western Sydney Clinical School, University of New South Wales, 2Ingham Institute for Applied Medical Research, 3Centre for Circulating Tumour Cell Diagnostics and Research, Ingham Institute for Applied Medical Research, 4Surgical Innovations Unit, Westmead Hospital, 5Westmead Clinical School, University of Sydney

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I den kliniske sammenhæng, patienter med lokaliseret kræft i bugspytkirtlen vil gennemgå pancreatectomy efterfulgt af adjuvans behandling. Denne protokol rapporteret her har til formål at etablere en sikker og effektiv metode til modellering dette kliniske scenario i nøgne mus, gennem orthotopic implantation af kræft i bugspytkirtlen efterfulgt af distal bugspytkirtelektomi og splenectomy.

Tags

Kræftforskning Problem 163 Bugspytkirtelkanalen adenocarcinoma (PDAC) Adjuvans terapi Neoadjuvansbehandling Pancreatectomy Orthotopic mus model Pancreas stellate celler
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