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Avansert hjerterytmehåndtering ved å bruke optogenetisk multi-site fotostimulering i murine hjerter

Article DOI: 10.3791/62335-v • 08:43 min • August 26th, 2021
August 26th, 2021 •
*1,2, *1, 8,9, 1,3,4,6, 8,9, 1,5,6,7
1Research Group Biomedical Physics, Max Planck Institute for Dynamics and Self-Organization, 2Research Electronics Department, Max Planck Institute for Dynamics and Self-Organization, 3Department of Pharmacology and Toxicology, University Medical Center Goettingen, 4Institute for Nonlinear Dynamics, Georg-August-University Goettingen, 5Department of Cardiology and Pneumology, University Medical Center Goettingen, 6German Center for Cardiovascular Research, DZHK e.V., partner site Goettingen, 7Laboratory Animal Science Unit, German Primate Center Leibniz Institute for Primate Research, 8Department of Microsystems Engineering (IMTEK), University of Freiburg, 9Cluster of Excellence BrainLinks-BrainTools, University of Freiburg
* These authors contributed equally

Kapitel

Summary
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Dette arbeidet rapporterer en metode for å kontrollere hjerterytmen til intakte murinhjerter av transgene kanalrhodopsin-2 (ChR2) mus ved hjelp av lokal fotostimulering med en mikro-LED-matrise og samtidig optisk kartlegging av epikardial membranpotensial.

Tags

Medisin cardiac optogenetics optisk kartlegging LED DI-4-ANBDQPQ Blebbistatin channelrhodopsin-2 ChR2
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