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Tam Anestezi Uygulanan Hemofili A Farelerinde Kuyruk Ven Transeksiyonu Kanama Modeli

Article DOI: 10.3791/62952-v • 08:13 min • September 30th, 2021
September 30th, 2021 •
1,2, 1, 1, 3, 1, 4, 5, 1, 6, 1
1Global Drug Discovery, Novo Nordisk A/S, 2Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 3Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, 4Independent consultant, 5Catalyst Biosciences, 6Værløse Dyreklinik

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Anestezi uygulanan farelerde rafine kuyruk veni transeksiyonu (TVT) kanama modeli, hemofilik kanamanın değerlendirilmesinde duyarlı bir in vivo yöntemdir. Bu optimize edilmiş TVT kanama modeli, kan kaybını ve kanama süresini bitiş noktaları olarak kullanır, diğer modelleri rafine eder ve son nokta olarak ölümden kaçınır.

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Biyoloji Sayı 175 kuyruk veni transeksiyon modeli kuyruk kanaması hayvan modeli farmakoloji müdahalesi hemofili faktör FVIII nakavt fareleri
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