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Journal / Medicine / Un modello di rimodellamento vascolare inverso…
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JoVE Journal Medicine
Un modello di rimodellamento vascolare inverso nell'ipertensione polmonare a causa di cardiopatia sinistra da debanding aortico nei ratti
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Un modello di rimodellamento vascolare inverso nell'ipertensione polmonare a causa di cardiopatia sinistra da debanding aortico nei ratti

Article DOI: 10.3791/63502-v • 07:41 min • March 1st, 2022
March 1st, 2022 •
1,2,3, 1,2,3, 2, 2, 2,3, *2,3, *1,3,4
1Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin (DHZB), 2Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 3DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 4Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
* These authors contributed equally

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Summary
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Il presente protocollo descrive una procedura chirurgica per rimuovere il banding ascendente-aortico in un modello di ratto di ipertensione polmonare dovuta a cardiopatia sinistra. Questa tecnica studia i meccanismi endogeni di rimodellamento inverso nella circolazione polmonare e nel cuore destro, informando così le strategie per invertire l'ipertensione polmonare e / o la disfunzione ventricolare destra.

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Medicina Numero 181
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