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Dosaggio multiplo in bolo endovenoso e valutazione emodinamica invasiva in un modello murino di ipertensione arteriosa polmonare indotta da ipossia

Article DOI: 10.3791/63839-v • 08:51 min • November 11th, 2022
November 11th, 2022 •
1, 2, 3, 3, 4,5, 4
1Department of Surgery, Yale University School of Medicine, 2Department of Vascular Surgery, The First Hospital of China Medical University, Key Laboratory of Pathogenesis, Prevention, and Therapeutics of Aortic Aneurysm, 3VasoRx Inc., 4Yale Cardiovascular Research Center, Department of Internal Medicine, Yale University School of Medicine, 5Department of Cell Biology, Yale University School of Medicine

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Questo protocollo fornisce una procedura passo-passo per l'esecuzione della somministrazione di dosi multiple in bolo endovenoso e il monitoraggio emodinamico invasivo nei topi. I ricercatori possono utilizzare questo protocollo per il futuro screening dei composti terapeutici per l'ipertensione arteriosa polmonare.

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Dosaggio in bolo endovenoso valutazione emodinamica invasiva modello di ipertensione arteriosa polmonare nel topo indotta da ipossia ipertensione arteriosa polmonare ricerca sulla PAH terapie sperimentali vena giugulare di topo cateterismo arterioso cateterismo del ventricolo destro modello PAH
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