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Journal / Bioengineering / Hydrogel Arrays Enable Increased Throughput for…
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Bioengineering

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JoVE Journal Bioengineering
Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models
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Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

Article DOI: 10.3791/63791-v • 10:49 min • June 16th, 2022
June 16th, 2022 •
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1University of California Los Angeles

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Summary
Automatic Translation

The present protocol describes an experimental platform to assess the effects of mechanical and biochemical cues on chemotherapeutic responses of patient-derived glioblastoma cells in 3D matrix-mimetic cultures using a custom-made UV illumination device facilitating high-throughput photocrosslinking of hydrogels with tunable mechanical features.

Tags

Hydrogel Arrays Increased Throughput Screening Effects Matrix Components Therapeutics 3D Tumor Models Matrix Cues Phenotype Of Cells High-throughput Implementation Matrix Conditions Tissue-mimetic Matrices Drug Resistance New Therapeutics HEPES-buffered Solution Thiolated HA Carboxylic Acid Residues Glucuronic Acid Thiol 8arm PEG Norbornene 4arm PEG Thiol Cysteine-containing Peptide
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