Alex B. Burgin SPARC Committee Broad Institute Biography Publications Institution JoVE Articles Alex B. Burgin has not added a biography. If you are Alex B. Burgin and would like to personalize this page please email our Author Liaison for assistance. Publications Non-helical DNA Triplex Forms a Unique Aptamer Scaffold for High Affinity Recognition of Nerve Growth Factor Structure (London, England : 1993). May, 2015 | Pubmed ID: 26027732 A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1 PloS One. 2015 | Pubmed ID: 25909780 Phosphodiesterase-4 (PDE4) Molecular Pharmacology and Alzheimer's Disease Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Jan, 2015 | Pubmed ID: 25371167 Discovery of Triazines As Selective PDE4B Versus PDE4D Inhibitors Bioorganic & Medicinal Chemistry Letters. Aug, 2014 | Pubmed ID: 24998378 Structural Basis for the Design of Selective Phosphodiesterase 4B Inhibitors Cellular Signalling. Mar, 2014 | Pubmed ID: 24361374 Structure and Function of a Cyanophage-encoded Peptide Deformylase The ISME Journal. Jun, 2013 | Pubmed ID: 23407310 Unique Motifs and Hydrophobic Interactions Shape the Binding of Modified DNA Ligands to Protein Targets Proceedings of the National Academy of Sciences of the United States of America. Dec, 2012 | Pubmed ID: 23139410 Artificial Neural Networks Trained to Detect Viral and Phage Structural Proteins PLoS Computational Biology. 2012 | Pubmed ID: 22927809 Resveratrol Ameliorates Aging-related Metabolic Phenotypes by Inhibiting CAMP Phosphodiesterases Cell. Feb, 2012 | Pubmed ID: 22304913 Small Molecule Allosteric Modulators of Phosphodiesterase 4 Handbook of Experimental Pharmacology. 2011 | Pubmed ID: 21695640 Use of Divalent Metal Ions in the DNA Cleavage Reaction of Topoisomerase IV Nucleic Acids Research. Jun, 2011 | Pubmed ID: 21300644 A Novel and Unified Two-metal Mechanism for DNA Cleavage by Type II and IA Topoisomerases Nature. Jun, 2010 | Pubmed ID: 20485342 Design of Phosphodiesterase 4D (PDE4D) Allosteric Modulators for Enhancing Cognition with Improved Safety Nature Biotechnology. Jan, 2010 | Pubmed ID: 20037581 Metal Ion Interactions in the DNA Cleavage/ligation Active Site of Human Topoisomerase IIalpha Biochemistry. Sep, 2009 | Pubmed ID: 19697956 Discovery of Leukotriene A4 Hydrolase Inhibitors Using Metabolomics Biased Fragment Crystallography Journal of Medicinal Chemistry. Aug, 2009 | Pubmed ID: 19618939 Use of Divalent Metal Ions in the Dna Cleavage Reaction of Human Type II Topoisomerases Biochemistry. Mar, 2009 | Pubmed ID: 19222228 Human Topoisomerase IIalpha Uses a Two-metal-ion Mechanism for DNA Cleavage Nucleic Acids Research. Sep, 2008 | Pubmed ID: 18653531 Using 3'-bridging Phosphorothiolates to Isolate the Forward DNA Cleavage Reaction of Human Topoisomerase IIalpha Biochemistry. Apr, 2008 | Pubmed ID: 18318502 Tyrosyl-DNA Phosphodiesterase (Tdp1) (3'-phosphotyrosyl DNA Phosphodiesterase) Methods in Enzymology. 2006 | Pubmed ID: 16793421 A Novel Norindenoisoquinoline Structure Reveals a Common Interfacial Inhibitor Paradigm for Ternary Trapping of the Topoisomerase I-DNA Covalent Complex Molecular Cancer Therapeutics. Feb, 2006 | Pubmed ID: 16505102 Uncoupling the Chemical Steps of Telomere Resolution by ResT The Journal of Biological Chemistry. Jul, 2005 | Pubmed ID: 15917226 Substrate Specificity of Tyrosyl-DNA Phosphodiesterase I (Tdp1) The Journal of Biological Chemistry. Jun, 2005 | Pubmed ID: 15811850 Structures of Three Classes of Anticancer Agents Bound to the Human Topoisomerase I-DNA Covalent Complex Journal of Medicinal Chemistry. Apr, 2005 | Pubmed ID: 15801827 DNA Ligation Catalyzed by Human Topoisomerase II Alpha Biochemistry. Oct, 2004 | Pubmed ID: 15491148 Substitution of Conserved Residues Within the Active Site Alters the Cleavage Religation Equilibrium of DNA Topoisomerase I The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15489506 Catalytic Residues of the Telomere Resolvase ResT: a Pattern Similar To, but Distinct From, Tyrosine Recombinases and Type IB Topoisomerases The Journal of Biological Chemistry. Dec, 2004 | Pubmed ID: 15471873 Design and Synthesis of Fluorescent Substrates for Human Tyrosyl-DNA Phosphodiesterase I Nucleic Acids Research. 2004 | Pubmed ID: 15333697 Mechanisms of Camptothecin Resistance by Human Topoisomerase I Mutations Journal of Molecular Biology. Jun, 2004 | Pubmed ID: 15165849 Analysis of Human Tyrosyl-DNA Phosphodiesterase I Catalytic Residues Journal of Molecular Biology. May, 2004 | Pubmed ID: 15111055 Quinolone Action Against Human Topoisomerase IIalpha: Stimulation of Enzyme-mediated Double-stranded DNA Cleavage Biochemistry. Apr, 2003 | Pubmed ID: 12653542 Structural Impact of the Leukemia Drug 1-beta-D-arabinofuranosylcytosine (Ara-C) on the Covalent Human Topoisomerase I-DNA Complex The Journal of Biological Chemistry. Apr, 2003 | Pubmed ID: 12533542 A Two-drug Model for Etoposide Action Against Human Topoisomerase IIalpha The Journal of Biological Chemistry. Feb, 2003 | Pubmed ID: 12473657 Regulation of Site-specific Recombination by the C-terminus of Lambda Integrase Nucleic Acids Research. Dec, 2002 | Pubmed ID: 12466544 The Mechanism of Topoisomerase I Poisoning by a Camptothecin Analog Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12426403 Human Topoisomerase IIalpha Possesses an Intrinsic Nucleic Acid Specificity for DNA Ligation. Use of 5' Covalently Activated Oligonucleotide Substrates to Study Enzyme Mechanism The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12050172 Phenomics فج: مقاربات الفسيولوجية لتوصيف رواية الفيروسية البروتينات Savannah E. Sanchez1, Daniel A. Cuevas2, Jason E. Rostron1, Tiffany Y. Liang3, Cullen G. Pivaroff1, Matthew R. Haynes1, Jim Nulton4, Ben Felts4, Barbara A. Bailey4, Peter Salamon4, Robert A. Edwards1,5,6, Alex B. Burgin7, Anca M. Segall1, Forest Rohwer1 1Department of Biology, San Diego State University, 2Computational Science Research Center, San Diego State University, 3Bioinformatics and Medical Informatics Research Center, San Diego State University, 4Department of Mathematics and Statistics, San Diego State University, 5Department of Computer Science, San Diego State University, 6Mathematics and Computer Science Division, Argonne National Laboratory, 7SPARC Committee, Broad Institute Inmunología e infección
Phenomics فج: مقاربات الفسيولوجية لتوصيف رواية الفيروسية البروتينات Savannah E. Sanchez1, Daniel A. Cuevas2, Jason E. Rostron1, Tiffany Y. Liang3, Cullen G. Pivaroff1, Matthew R. Haynes1, Jim Nulton4, Ben Felts4, Barbara A. Bailey4, Peter Salamon4, Robert A. Edwards1,5,6, Alex B. Burgin7, Anca M. Segall1, Forest Rohwer1 1Department of Biology, San Diego State University, 2Computational Science Research Center, San Diego State University, 3Bioinformatics and Medical Informatics Research Center, San Diego State University, 4Department of Mathematics and Statistics, San Diego State University, 5Department of Computer Science, San Diego State University, 6Mathematics and Computer Science Division, Argonne National Laboratory, 7SPARC Committee, Broad Institute Inmunología e infección