Alex Vitkin Department of Medical Biophysics University of Toronto Biography Publications Institution JoVE Articles Alex Vitkin has not added a biography. If you are Alex Vitkin and would like to personalize this page please email our Author Liaison for assistance. Publications Machine Learning Based Local Recurrence Prediction in Colorectal Cancer Using Polarized Light Imaging Journal of Biomedical Optics. May, 2024 | Pubmed ID: 38077502 Protein Classification by Autofluorescence Spectral Shape Analysis Using Machine Learning Talanta. Jan, 2024 | Pubmed ID: 37714041 Advances in Laser Speckle Imaging: From Qualitative to Quantitative Hemodynamic Assessment Journal of Biophotonics. Jan, 2024 | Pubmed ID: 37545037 Spatial Analysis of Polarimetric Images to Enhance Near-surface Sampling Sensitivity: Feasibility in Demineralized Teeth and Other Tissue-like Media Journal of Biomedical Optics. Oct, 2023 | Pubmed ID: 37692083 Mueller Matrix Polarization Parameters Correlate with Local Recurrence in Patients with Stage III Colorectal Cancer Scientific Reports. Aug, 2023 | Pubmed ID: 37591987 Spatial Helicity Response Metric to Quantify Particle Size and Turbidity of Heterogeneous Media Through Circular Polarization Imaging Scientific Reports. Feb, 2023 | Pubmed ID: 36755076 Detection and Differentiation of Semi-transparent Materials Simulating Biological Structures Using Optical Coherence Tomography: a Phantom Study Journal of Biomedical Optics. Oct, 2022 | Pubmed ID: 36221173 Binary Dose Level Classification of Tumour Microvascular Response to Radiotherapy Using Artificial Intelligence Analysis of Optical Coherence Tomography Images Scientific Reports. Aug, 2022 | Pubmed ID: 35978040 Polarimetric Biomarkers of Peri-tumoral Stroma Can Correlate with 5-year Survival in Patients with Left-sided Colorectal Cancer Scientific Reports. Jul, 2022 | Pubmed ID: 35879367 Longitudinal In-vivo Quantification of Tumour Microvascular Heterogeneity by Optical Coherence Angiography in Pre-clinical Radiation Therapy Scientific Reports. Apr, 2022 | Pubmed ID: 35414078 Bridging the Macro to Micro Resolution Gap with Angiographic Optical Coherence Tomography and Dynamic Contrast Enhanced MRI Scientific Reports. Feb, 2022 | Pubmed ID: 35210476 Discriminating Turbid Media by Scatterer Size and Scattering Coefficient Using Backscattered Linearly and Circularly Polarized Light Biomedical Optics Express. Nov, 2021 | Pubmed ID: 34858683 Diattenuation and Retardance Signature of Plasmonic Gold Nanorods in Turbid Media Revealed by Mueller Matrix Polarimetry Scientific Reports. Oct, 2021 | Pubmed ID: 34625628 Toward a Quantitative Method for Estimating Tumour-stroma Ratio in Breast Cancer Using Polarized Light Microscopy Biomedical Optics Express. Jun, 2021 | Pubmed ID: 34221657 Low-coherence Photonic Method of Electrochemical Processes Monitoring Scientific Reports. Jun, 2021 | Pubmed ID: 34131215 Volumetric Tumor Delineation and Assessment of Its Early Response to Radiotherapy with Optical Coherence Tomography Biomedical Optics Express. May, 2021 | Pubmed ID: 34123510 Peri-tumoural Stroma Collagen Organization of Invasive Ductal Carcinoma Assessed by Polarized Light Microscopy Differs Between OncotypeDX Risk Group Journal of Biophotonics. Nov, 2020 | Pubmed ID: 32710711 Dual-Agent Photodynamic Therapy with Optical Clearing Eradicates Pigmented Melanoma in Preclinical Tumor Models Cancers. Jul, 2020 | Pubmed ID: 32708501 Novel Quantitative Signature of Tumor Stromal Architecture: Polarized Light Imaging Differentiates Between Myxoid and Sclerotic Human Breast Cancer Stroma Biomedical Optics Express. Jun, 2020 | Pubmed ID: 32637252 Correction To: A Multiscale Mueller Polarimetry Module for a Stereo Zoom Microscope Biomedical Engineering Letters. Feb, 2020 | Pubmed ID: 32175138 Impact of Velocity Gradient in Poiseuille Flow on the Statistics of Coherent Radiation Scattered by Flowing Brownian Particles in Optical Coherence Tomography Journal of Biomedical Optics. Sep, 2019 | Pubmed ID: 31562708 A Multiscale Mueller Polarimetry Module for a Stereo Zoom Microscope Biomedical Engineering Letters. Aug, 2019 | Pubmed ID: 31456893 Photon Mayhem: New Directions in Diagnostic and Therapeutic Photomedicine Biomedical Engineering Letters. Aug, 2019 | Pubmed ID: 31456888 Analysis of Low-scattering Regions in Optical Coherence Tomography: Applications to Neurography and Lymphangiography Biomedical Optics Express. Aug, 2019 | Pubmed ID: 31453005 Novel Methodology to Image Stromal Tissue and Assess Its Morphological Features with Polarized Light: Towards a Tumour Microenvironment Prognostic Signature Biomedical Optics Express. Aug, 2019 | Pubmed ID: 31452988 Non-invasive Voiding Assessment in Conscious Mice Bladder (San Francisco, Calif.). 2018 | Pubmed ID: 32775475 Preclinical Quantitative In-vivo Assessment of Skin Tissue Vascularity in Radiation-induced Fibrosis with Optical Coherence Tomography Journal of Biomedical Optics. Oct, 2018 | Pubmed ID: 30315644 Monte Carlo Simulation of Polarization-sensitive Second-harmonic Generation and Propagation in Biological Tissue Journal of Biophotonics. Dec, 2018 | Pubmed ID: 29971932 Optical Coherence Tomography-based Angiography Device with Real-time Angiography B-scans Visualization and Hand-held Probe for Everyday Clinical Use Journal of Biophotonics. Oct, 2018 | Pubmed ID: 29737042 Preclinical Longitudinal Imaging of Tumor Microvascular Radiobiological Response with Functional Optical Coherence Tomography Scientific Reports. Jan, 2018 | Pubmed ID: 29311686 Pixel Classification Method in Optical Coherence Tomography for Tumor Segmentation and Its Complementary Usage with OCT Microangiography Journal of Biophotonics. Apr, 2018 | Pubmed ID: 28853237 K-distribution Three-dimensional Mapping of Biological Tissues in Optical Coherence Tomography Journal of Biophotonics. Mar, 2018 | Pubmed ID: 28700119 Flexible Polarimetric Probe for 3 × 3 Mueller Matrix Measurements of Biological Tissue Scientific Reports. Sep, 2017 | Pubmed ID: 28931853 Accurate Viscosity Measurements of Flowing Aqueous Glucose Solutions with Suspended Scatterers Using a Dynamic Light Scattering Approach with Optical Coherence Tomography Journal of Biomedical Optics. Aug, 2017 | Pubmed ID: 28861954 Statistical Properties of Dynamic Speckles from Flowing Brownian Scatterers in the Vicinity of the Image Plane in Optical Coherence Tomography Biomedical Optics Express. Apr, 2017 | Pubmed ID: 28736652 Optical Coherence Elastography for Strain Dynamics Measurements in Laser Correction of Cornea Shape Journal of Biophotonics. Nov, 2017 | Pubmed ID: 28493426 Polarization Image Segmentation of Radiofrequency Ablated Porcine Myocardial Tissue PloS One. 2017 | Pubmed ID: 28380013 Optimized Mass Spectrometry Analysis Workflow with Polarimetric Guidance for Ex Vivo and in Situ Sampling of Biological Tissues Scientific Reports. Mar, 2017 | Pubmed ID: 28352074 Wide-field Tissue Polarimetry Allows Efficient Localized Mass Spectrometry Imaging of Biological Tissues Chemical Science. Mar, 2016 | Pubmed ID: 30155015 Optimized Phase Gradient Measurements and Phase-amplitude Interplay in Optical Coherence Elastography Journal of Biomedical Optics. Nov, 2016 | Pubmed ID: 27824215 Rapid Detection of Necrosis in Breast Cancer with Desorption Electrospray Ionization Mass Spectrometry Scientific Reports. Oct, 2016 | Pubmed ID: 27734938 Microvascular Contrast Enhancement in Optical Coherence Tomography Using Microbubbles Journal of Biomedical Optics. Jul, 2016 | Pubmed ID: 27533242 Special Issue: Selected Papers from the Topical Problems of Biophotonics Conference Journal of Biophotonics. Aug, 2016 | Pubmed ID: 27480644 Analysis of Scattering Statistics and Governing Distribution Functions in Optical Coherence Tomography Biomedical Optics Express. Jul, 2016 | Pubmed ID: 27446689 Optical Clearing of Melanoma in Vivo: Characterization by Diffuse Reflectance Spectroscopy and Optical Coherence Tomography Journal of Biomedical Optics. Aug, 2016 | Pubmed ID: 27300502 Hybrid Method of Strain Estimation in Optical Coherence Elastography Using Combined Sub-wavelength Phase Measurements and Supra-pixel Displacement Tracking Journal of Biophotonics. May, 2016 | Pubmed ID: 27159850 Dynamic Light Scattering by Flowing Brownian Particles Measured with Optical Coherence Tomography: Impact of the Optical System Journal of Biomedical Optics. Jan, 2016 | Pubmed ID: 26803671 Multi-modal Optical Imaging Characterization of Atherosclerotic Plaques Journal of Biophotonics. Oct, 2016 | Pubmed ID: 26604168 Polarimetric Assessment of Healthy and Radiofrequency Ablated Porcine Myocardial Tissue Journal of Biophotonics. Jul, 2016 | Pubmed ID: 26394151 Talin Is Required Continuously for Cardiomyocyte Remodeling During Heart Growth in Drosophila PloS One. 2015 | Pubmed ID: 26110760 Differential Diagnosis of Human Bladder Mucosa Pathologies in Vivo with Cross-polarization Optical Coherence Tomography Biomedical Optics Express. Apr, 2015 | Pubmed ID: 25909028 Polarized Light Imaging in Biomedicine: Emerging Mueller Matrix Methodologies for Bulk Tissue Assessment Journal of Biomedical Optics. Jun, 2015 | Pubmed ID: 25793658 Dynamic Light Scattering Arising from Flowing Brownian Particles: Analytical Model in Optical Coherence Tomography Conditions Journal of Biomedical Optics. Dec, 2014 | Pubmed ID: 25517256 Tissue Multifractality and Born Approximation in Analysis of Light Scattering: a Novel Approach for Precancers Detection Scientific Reports. Aug, 2014 | Pubmed ID: 25139583 Assessment of Local Structural Disorders of the Bladder Wall in Partial Bladder Outlet Obstruction Using Polarized Light Imaging Biomedical Optics Express. Feb, 2014 | Pubmed ID: 24575354 Optical Coherence Tomography Platform for Microvascular Imaging and Quantification: Initial Experience in Late Oral Radiation Toxicity Patients Journal of Biomedical Optics. Jul, 2013 | Pubmed ID: 23843086 Texture Analysis of Optical Coherence Tomography Speckle for Characterizing Biological Tissues in Vivo Optics Letters. Apr, 2013 | Pubmed ID: 23595458 A Spinal Cord Window Chamber Model for in Vivo Longitudinal Multimodal Optical and Acoustic Imaging in a Murine Model PloS One. 2013 | Pubmed ID: 23516432 Detecting Axial Heterogeneity of Birefringence in Layered Turbid Media Using Polarized Light Imaging Biomedical Optics Express. Dec, 2012 | Pubmed ID: 23243575 Optical Assessment of Tissue Anisotropy in Ex Vivo Distended Rat Bladders Journal of Biomedical Optics. Aug, 2012 | Pubmed ID: 23224197 Quantifying Tissue Microvasculature with Speckle Variance Optical Coherence Tomography Optics Letters. Aug, 2012 | Pubmed ID: 22859125 Quantitative Correlation Between Light Depolarization and Transport Albedo of Various Porcine Tissues Journal of Biomedical Optics. Apr, 2012 | Pubmed ID: 22559678 Elastin Overexpression by Cell-based Gene Therapy Preserves Matrix and Prevents Cardiac Dilation Journal of Cellular and Molecular Medicine. Oct, 2012 | Pubmed ID: 22435995 Two-photon Microscopy of Healthy, Infarcted and Stem-cell Treated Regenerating Heart Journal of Biophotonics. May, 2011 | Pubmed ID: 20827682 Polarimetry-based Method to Extract Geometry-independent Metrics of Tissue Anisotropy Optics Letters. Aug, 2010 | Pubmed ID: 20680061 Optimized Speckle Variance OCT Imaging of Microvasculature Optics Letters. Apr, 2010 | Pubmed ID: 20410985 Doppler Optical Coherence Tomography for Interventional Cardiovascular Guidance: in Vivo Feasibility and Forward-viewing Probe Flow Phantom Demonstration Journal of Biomedical Optics. 2010 | Pubmed ID: 20210429 In Vivo Endoscopic Multi-beam Optical Coherence Tomography Physics in Medicine and Biology. Feb, 2010 | Pubmed ID: 20071753 Depolarization of Light in Turbid Media: a Scattering Event Resolved Monte Carlo Study Applied Optics. Jan, 2010 | Pubmed ID: 20062501 Oxygen-independent Degradation of HIF-alpha Via Bioengineered VHL Tumour Suppressor Complex EMBO Molecular Medicine. Apr, 2009 | Pubmed ID: 20049704 High-power Wavelength-swept Laser in Littman Telescope-less Polygon Filter and Dual-amplifier Configuration for Multichannel Optical Coherence Tomography Optics Letters. Sep, 2009 | Pubmed ID: 19756114 Interstitial Doppler Optical Coherence Tomography As a Local Tumor Necrosis Predictor in Photodynamic Therapy of Prostatic Carcinoma: an in Vivo Study Cancer Research. Dec, 2008 | Pubmed ID: 19047181 Temperature and Hydration Effects on Absorbance Spectra and Radiation Sensitivity of a Radiochromic Medium Medical Physics. Oct, 2008 | Pubmed ID: 18975701 High Power Wavelength Linearly Swept Mode Locked Fiber Laser for OCT Imaging Optics Express. Sep, 2008 | Pubmed ID: 18773019 Speckle Variance Detection of Microvasculature Using Swept-source Optical Coherence Tomography Optics Letters. Jul, 2008 | Pubmed ID: 18594688 Electrostatic Forward-viewing Scanning Probe for Doppler Optical Coherence Tomography Using a Dissipative Polymer Catheter Optics Letters. Apr, 2008 | Pubmed ID: 18382508 Determination of the Optical Properties of Turbid Media Using Relative Interstitial Radiance Measurements: Monte Carlo Study, Experimental Validation, and Sensitivity Analysis Journal of Biomedical Optics. 2007 | Pubmed ID: 18163843 Intra-irradiation Changes in the Signal of Polymer-based Dosimeter (GAFCHROMIC EBT) Due to Dose Rate Variations Physics in Medicine and Biology. Nov, 2007 | Pubmed ID: 17975282 Doppler Optical Coherence Tomography Monitoring of Microvascular Tissue Response During Photodynamic Therapy in an Animal Model of Barrett's Esophagus Gastrointestinal Endoscopy. Aug, 2007 | Pubmed ID: 17643708 Interstitial Doppler Optical Coherence Tomography Monitors Microvascular Changes During Photodynamic Therapy in a Dunning Prostate Model Under Varying Treatment Conditions Journal of Biomedical Optics. May-Jun, 2007 | Pubmed ID: 17614730 Energy Dependence (75 KVp to 18 MV) of Radiochromic Films Assessed Using a Real-time Optical Dosimeter Medical Physics. Feb, 2007 | Pubmed ID: 17388161 Perturbative Diffusion Theory Formalism for Interpreting Temporal Light Intensity Changes During Laser Interstitial Thermal Therapy Physics in Medicine and Biology. Mar, 2007 | Pubmed ID: 17327655 Ex Vivo Imaging of Chronic Total Occlusions Using Forward-looking Optical Coherence Tomography Lasers in Surgery and Medicine. Jan, 2007 | Pubmed ID: 17096416 Angular Measurements of Light Scattered by Turbid Chiral Media Using Linear Stokes Polarimeter Journal of Biomedical Optics. 2006 | Pubmed ID: 16965133 Feasibility of Interstitial Doppler Optical Coherence Tomography for in Vivo Detection of Microvascular Changes During Photodynamic Therapy Lasers in Surgery and Medicine. Sep, 2006 | Pubmed ID: 16927368 Information Content of Point Radiance Measurements in Turbid Media: Implications for Interstitial Optical Property Quantification Applied Optics. Mar, 2006 | Pubmed ID: 16579581 Laser Photothermoacoustic Heterodyned Lock-in Depth Profilometry in Turbid Tissue Phantoms Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Nov, 2005 | Pubmed ID: 16383646 Characterization and Real-time Optical Measurements of the Ionizing Radiation Dose Response for a New Radiochromic Medium Medical Physics. Aug, 2005 | Pubmed ID: 16193781 Optical and Acoustic Properties at 1064 Nm of Polyvinyl Chloride-plastisol for Use As a Tissue Phantom in Biomedical Optoacoustics Physics in Medicine and Biology. Jul, 2005 | Pubmed ID: 16177502 Endoscopic Doppler Optical Coherence Tomography in the Human GI Tract: Initial Experience Gastrointestinal Endoscopy. Jun, 2005 | Pubmed ID: 15933695 Suitability of Radiochromic Medium for Real-time Optical Measurements of Ionizing Radiation Dose Medical Physics. Apr, 2005 | Pubmed ID: 15895598 Development of a Laser Photothermoacoustic Frequency-swept System for Subsurface Imaging: Theory and Experiment The Journal of the Acoustical Society of America. Dec, 2004 | Pubmed ID: 15658704 Micromachined Array Tip for Multifocus Fiber-based Optical Coherence Tomography Optics Letters. Aug, 2004 | Pubmed ID: 15352360 Radiance-based Monitoring of the Extent of Tissue Coagulation During Laser Interstitial Thermal Therapy Optics Letters. May, 2004 | Pubmed ID: 15143640 Models and Measurements of Light Intensity Changes During Laser Interstitial Thermal Therapy: Implications for Optical Monitoring of the Coagulation Boundary Location Physics in Medicine and Biology. Feb, 2003 | Pubmed ID: 12630747 Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning W. Jeffrey Zabel*1, Nader Allam*1, Hector Alejandro Contreras Sanchez1, Warren Foltz2,3, Costel Flueraru4, Edward Taylor2,3, Alex Vitkin1,2,3 1Department of Medical Biophysics, University of Toronto, 2Radiation Medicine Program, Princess Margaret Cancer Centre, 3Department of Radiation Oncology, University of Toronto, 4Advanced Electronic and Photonics Research Center, National Research Council of Canada JoVE 66383 Investigación sobre el cáncer
Author Spotlight: Integrating High-Resolution Intravital Imaging and MRI to Enhance Stereotactic Body Radiation Therapy Planning W. Jeffrey Zabel*1, Nader Allam*1, Hector Alejandro Contreras Sanchez1, Warren Foltz2,3, Costel Flueraru4, Edward Taylor2,3, Alex Vitkin1,2,3 1Department of Medical Biophysics, University of Toronto, 2Radiation Medicine Program, Princess Margaret Cancer Centre, 3Department of Radiation Oncology, University of Toronto, 4Advanced Electronic and Photonics Research Center, National Research Council of Canada JoVE 66383 Investigación sobre el cáncer
