David K Cole

Publications

• Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase
  The Journal of Biological Chemistry. Jan, 2017  |   Pubmed ID: 27903649
• Hotspot Autoimmune T Cell Receptor Binding Underlies Pathogen and Insulin Peptide Cross-reactivity
  The Journal of Clinical Investigation. Sep, 2016  |   Pubmed ID: 27525441
• Hotspot Autoimmune T Cell Receptor Binding Underlies Pathogen and Insulin Peptide Cross-reactivity
  The Journal of Clinical Investigation. Jun, 2016  |   Pubmed ID: 27183389
• A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen
  The Journal of Biological Chemistry. Apr, 2016  |   Pubmed ID: 26917722
• T-cell Libraries Allow Simple Parallel Generation of Multiple Peptide-specific Human T-cell Clones
  Journal of Immunological Methods. Mar, 2016  |   Pubmed ID: 26826277
• Direct Molecular Mimicry Enables Off-target Cardiovascular Toxicity by an Enhanced Affinity TCR Designed for Cancer Immunotherapy
  Scientific Reports. Jan, 2016  |   Pubmed ID: 26758806
• Enhanced Detection of Antigen-Specific CD4+ T Cells Using Altered Peptide Flanking Residue Peptide-MHC Class II Multimers
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2015  |   Pubmed ID: 26553072
• Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide
  The Journal of Biological Chemistry. Jul, 2015  |   Pubmed ID: 26085090
• More Tricks with Tetramers: a Practical Guide to Staining T Cells with Peptide-MHC Multimers
  Immunology. Sep, 2015  |   Pubmed ID: 26076649
• The Promise of γδ T Cells and the γδ T Cell Receptor for Cancer Immunotherapy
  Cellular & Molecular Immunology. Nov, 2015  |   Pubmed ID: 25864915
• The Ultimate Mix and Match: Making Sense of HLA Alleles and Peptide Repertoires
  Immunology and Cell Biology. Jul, 2015  |   Pubmed ID: 25823993
• A Molecular Switch in Immunodominant HIV-1-specific CD8 T-cell Epitopes Shapes Differential HLA-restricted Escape
  Retrovirology. Feb, 2015  |   Pubmed ID: 25808313
• Naive CD8⁺ T-cell Precursors Display Structured TCR Repertoires and Composite Antigen-driven Selection Dynamics
  Immunology and Cell Biology. Aug, 2015  |   Pubmed ID: 25801351
• Structural Basis for Ineffective T-cell Responses to MHC Anchor Residue-improved "heteroclitic" Peptides
  European Journal of Immunology. Feb, 2015  |   Pubmed ID: 25471691
• Antibody Stabilization of Peptide-MHC Multimers Reveals Functional T Cells Bearing Extremely Low-affinity TCRs
  Journal of Immunology (Baltimore, Md. : 1950). Jan, 2015  |   Pubmed ID: 25452566
• Recurrence of Melanoma Following T Cell Treatment: Continued Antigen Expression in a Tumor That Evades T Cell Recruitment
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2015  |   Pubmed ID: 25363716
• Coreceptor Scanning by the T Cell Receptor Provides a Mechanism for T Cell Tolerance
  Cell. Oct, 2014  |   Pubmed ID: 25284152
• Molecular Basis of a Dominant T Cell Response to an HIV Reverse Transcriptase 8-mer Epitope Presented by the Protective Allele HLA-B*51:01
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2014  |   Pubmed ID: 24600035
• The Versatility of the αβ T-cell Antigen Receptor
  Protein Science : a Publication of the Protein Society. Mar, 2014  |   Pubmed ID: 24375592
• T-cell Receptor (TCR)-peptide Specificity Overrides Affinity-enhancing TCR-major Histocompatibility Complex Interactions
  The Journal of Biological Chemistry. Jan, 2014  |   Pubmed ID: 24196962
• Cellular-level Versus Receptor-level Response Threshold Hierarchies in T-cell Activation
  Frontiers in Immunology. 2013  |   Pubmed ID: 24046768
• Re-Directing CD4(+) T Cell Responses with the Flanking Residues of MHC Class II-Bound Peptides: The Core is Not Enough
  Frontiers in Immunology. 2013  |   Pubmed ID: 23847615
• Increased Peptide Contacts Govern High Affinity Binding of a Modified TCR Whilst Maintaining a Native PMHC Docking Mode
  Frontiers in Immunology. 2013  |   Pubmed ID: 23805144
• T-cell Receptor Specificity Maintained by Altered Thermodynamics
  The Journal of Biological Chemistry. Jun, 2013  |   Pubmed ID: 23698002
• Peptide Length Determines the Outcome of TCR/peptide-MHCI Engagement
  Blood. Feb, 2013  |   Pubmed ID: 23255554
• Human β-cell Killing by Autoreactive Preproinsulin-specific CD8 T Cells is Predominantly Granule-mediated with the Potency Dependent Upon T-cell Receptor Avidity
  Diabetes. Jan, 2013  |   Pubmed ID: 22936177
• Minimal Conformational Plasticity Enables TCR Cross-reactivity to Different MHC Class II Heterodimers
  Scientific Reports. 2012  |   Pubmed ID: 22953050
• T-cell Receptor-optimized Peptide Skewing of the T-cell Repertoire Can Enhance Antigen Targeting
  The Journal of Biological Chemistry. Oct, 2012  |   Pubmed ID: 22952231
• The Molecular Determinants of CD8 Co-receptor Function
  Immunology. Oct, 2012  |   Pubmed ID: 22804746
• TCR/pMHC Optimized Protein Crystallization Screen
  Journal of Immunological Methods. Aug, 2012  |   Pubmed ID: 22705983
• Modification of the Carboxy-terminal Flanking Region of a Universal Influenza Epitope Alters CD4⁺ T-cell Repertoire Selection
  Nature Communications. Feb, 2012  |   Pubmed ID: 22314361
• Structural Basis for the Killing of Human Beta Cells by CD8(+) T Cells in Type 1 Diabetes
  Nature Immunology. Jan, 2012  |   Pubmed ID: 22245737
• Structural and Biophysical Determinants of αβ T-cell Antigen Recognition
  Immunology. Jan, 2012  |   Pubmed ID: 22044041
• The Multiple Roles of the CD8 Coreceptor in T Cell Biology: Opportunities for the Selective Modulation of Self-reactive Cytotoxic T Cells
  Journal of Leukocyte Biology. Dec, 2011  |   Pubmed ID: 21954283
• Correlation of in Situ Mechanosensitive Responses of the Moraxella Catarrhalis Adhesin UspA1 with Fibronectin and Receptor CEACAM1 Binding
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011  |   Pubmed ID: 21876142
• Anti-CD8 Antibodies Can Trigger CD8+ T Cell Effector Function in the Absence of TCR Engagement and Improve Peptide-MHCI Tetramer Staining
  Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011  |   Pubmed ID: 21677135
• Real Time Detection of Peptide-MHC Dissociation Reveals That Improvement of Primary MHC-binding Residues Can Have a Minimal, or No, Effect on Stability
  Molecular Immunology. Jan, 2011  |   Pubmed ID: 21130497
• Genetic and Structural Basis for Selection of a Ubiquitous T Cell Receptor Deployed in Epstein-Barr Virus Infection
  PLoS Pathogens. Nov, 2010  |   Pubmed ID: 21124993
• Modification of MHC Anchor Residues Generates Heteroclitic Peptides That Alter TCR Binding and T Cell Recognition
  Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010  |   Pubmed ID: 20639478
• MHC Class I Molecules with Superenhanced CD8 Binding Properties Bypass the Requirement for Cognate TCR Recognition and Nonspecifically Activate CTLs
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2010  |   Pubmed ID: 20190139
• T Cell Receptor Cross-reactivity Directed by Antigen-dependent Tuning of Peptide-MHC Molecular Flexibility
  Immunity. Dec, 2009  |   Pubmed ID: 20064447
• ELISPOT and Functional T Cell Analyses Using HLA Mono-specific Target Cells
  Journal of Immunological Methods. Oct, 2009  |   Pubmed ID: 19729014
• Peptide-major Histocompatibility Complex Dimensions Control Proximal Kinase-phosphatase Balance During T Cell Activation
  The Journal of Biological Chemistry. Sep, 2009  |   Pubmed ID: 19628870
• Germ Line-governed Recognition of a Cancer Epitope by an Immunodominant Human T-cell Receptor
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19605354
• Tricks with Tetramers: How to Get the Most from Multimeric Peptide-MHC
  Immunology. Feb, 2009  |   Pubmed ID: 19125886
• Control of HIV-1 Immune Escape by CD8 T Cells Expressing Enhanced T-cell Receptor
  Nature Medicine. Dec, 2008  |   Pubmed ID: 18997777
• Detection of Low Avidity CD8(+) T Cell Populations with Coreceptor-enhanced Peptide-major Histocompatibility Complex Class I Tetramers
  Journal of Immunological Methods. Sep, 2008  |   Pubmed ID: 18675271
• T Cell Receptor Engagement of Peptide-major Histocompatibility Complex Class I Does Not Modify CD8 Binding
  Molecular Immunology. May, 2008  |   Pubmed ID: 18243322
• Different T Cell Receptor Affinity Thresholds and CD8 Coreceptor Dependence Govern Cytotoxic T Lymphocyte Activation and Tetramer Binding Properties
  The Journal of Biological Chemistry. Aug, 2007  |   Pubmed ID: 17540778
• Human TCR-binding Affinity is Governed by MHC Class Restriction
  Journal of Immunology (Baltimore, Md. : 1950). May, 2007  |   Pubmed ID: 17442956
• Functional and Biophysical Characterization of an HLA-A*6801-restricted HIV-specific T Cell Receptor
  European Journal of Immunology. Feb, 2007  |   Pubmed ID: 17273992
• Computational Design and Crystal Structure of an Enhanced Affinity Mutant Human CD8 Alphaalpha Coreceptor
  Proteins. Apr, 2007  |   Pubmed ID: 17243170
• Crystal Structure of HLA-A*2402 Complexed with a Telomerase Peptide
  European Journal of Immunology. Jan, 2006  |   Pubmed ID: 16323248
• Crystallization and Preliminary X-ray Structural Studies of a High-affinity CD8alphaalpha Co-receptor to PMHC
  Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Mar, 2005  |   Pubmed ID: 16511019
• CD8: Adhesion Molecule, Co-receptor and Immuno-modulator
  Cellular & Molecular Immunology. Apr, 2004  |   Pubmed ID: 16212893
• Characterization of the Heptad Repeat Regions, HR1 and HR2, and Design of a Fusion Core Structure Model of the Spike Protein from Severe Acute Respiratory Syndrome (SARS) Coronavirus
  Biochemistry. Nov, 2004  |   Pubmed ID: 15518555
• Construct Design, Biophysical, and Biochemical Characterization of the Fusion Core from Mouse Hepatitis Virus (a Coronavirus) Spike Protein
  Protein Expression and Purification. Nov, 2004  |   Pubmed ID: 15477089
• Biochemical, Biophysical and Preliminary X-ray Crystallographic Analyses of the Fusion Core of Sendai Virus F Protein
  Acta Crystallographica. Section D, Biological Crystallography. Sep, 2004  |   Pubmed ID: 15333939
• Complex Assembly, Crystallization and Preliminary X-ray Crystallographic Studies of MHC H-2Kd Complexed with an HBV-core Nonapeptide
  Acta Crystallographica. Section D, Biological Crystallography. Aug, 2004  |   Pubmed ID: 15272181
• SARS Coronavirus Induces Apoptosis in Vero E6 Cells
  Journal of Medical Virology. Jul, 2004  |   Pubmed ID: 15170624
• Crystallization and Preliminary Crystallographic Analysis of the Fusion Core from Two New Zoonotic Paramyxoviruses, Nipah Virus and Hendra Virus
  Acta Crystallographica. Section D, Biological Crystallography. Jun, 2004  |   Pubmed ID: 15159588
• Following the Rule: Formation of the 6-helix Bundle of the Fusion Core from Severe Acute Respiratory Syndrome Coronavirus Spike Protein and Identification of Potent Peptide Inhibitors
  Biochemical and Biophysical Research Communications. Jun, 2004  |   Pubmed ID: 15158473
• Basis for Fusion Inhibition by Peptides: Analysis of the Heptad Repeat Regions of the Fusion Proteins from Nipah and Hendra Viruses, Newly Emergent Zoonotic Paramyxoviruses
  Biochemical and Biophysical Research Communications. Mar, 2004  |   Pubmed ID: 14975752