David P. Speert Department of Pediatrics, Centre for Understanding and Preventing Infection in Children University of British Columbia Biography Publications Institution JoVE Articles David P. Speert has not added a biography. If you are David P. Speert and would like to personalize this page please email our Author Liaison for assistance. Publications Recurrent Subacute Post-viral Onset of Ataxia Associated with a PRF1 Mutation European Journal of Human Genetics : EJHG. Feb, 2013 | Pubmed ID: 23443029 Antibody Responses to Vaccination Among South African HIV-exposed and Unexposed Uninfected Infants During the First 2 Years of Life Clinical and Vaccine Immunology : CVI. Jan, 2013 | Pubmed ID: 23114697 Ontogeny of Toll-like Receptor Mediated Cytokine Responses of South African Infants Throughout the First Year of Life PloS One. 2012 | Pubmed ID: 23028609 Serum Susceptibility in Clinical Isolates of Burkholderia Cepacia Complex Bacteria: Development of a Growth-based Assay for High Throughput Determination Frontiers in Cellular and Infection Microbiology. 2012 | Pubmed ID: 22919658 Influence of Common Non-synonymous Toll-like Receptor 4 Polymorphisms on Bronchopulmonary Dysplasia and Prematurity in Human Infants PloS One. 2012 | Pubmed ID: 22348075 Identification of Differentially Expressed Proteins from Burkholderia Pseudomallei Isolated During Primary and Relapsing Melioidosis Microbes and Infection / Institut Pasteur. Apr, 2012 | Pubmed ID: 22172334 Identification of Hopanoid Biosynthesis Genes Involved in Polymyxin Resistance in Burkholderia Multivorans Antimicrobial Agents and Chemotherapy. Jan, 2012 | Pubmed ID: 22006009 Mucoid Morphotype Variation of Burkholderia Multivorans During Chronic Cystic Fibrosis Lung Infection is Correlated with Changes in Metabolism, Motility, Biofilm Formation and Virulence Microbiology (Reading, England). Nov, 2011 | Pubmed ID: 21835880 In Vivo-transmigrated Human Neutrophils Are Resistant to Antiapoptotic Stimulation Journal of Leukocyte Biology. Dec, 2011 | Pubmed ID: 21697259 In Vitro Susceptibility of Burkholderia Vietnamiensis to Aminoglycosides Antimicrobial Agents and Chemotherapy. May, 2011 | Pubmed ID: 21321142 Mucoid and Nonmucoid Burkholderia Cepacia Complex Bacteria in Cystic Fibrosis Infections American Journal of Respiratory and Critical Care Medicine. Jan, 2011 | Pubmed ID: 20709823 Clinical Features and Outcome of Patients with IRAK-4 and MyD88 Deficiency Medicine. Nov, 2010 | Pubmed ID: 21057262 Profound Lack of Interleukin (IL)-12/IL-23p40 in Neonates Born Early in Gestation is Associated with an Increased Risk of Sepsis The Journal of Infectious Diseases. Dec, 2010 | Pubmed ID: 20977341 Parallel Evolution in Pseudomonas Aeruginosa over 39,000 Generations in Vivo MBio. 2010 | Pubmed ID: 20856824 Toll-like Receptor Gene Polymorphisms and Preeclampsia Risk: a Case-control Study and Data Synthesis Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy. 2010 | Pubmed ID: 20818954 The Role of Mucoidy in Virulence of Bacteria from the Burkholderia Cepacia Complex: a Systematic Proteomic and Transcriptomic Analysis The Journal of Infectious Diseases. Sep, 2010 | Pubmed ID: 20670172 Mycobacterium Tuberculosis Employs Cpn60.2 As an Adhesin That Binds CD43 on the Macrophage Surface Cellular Microbiology. Nov, 2010 | Pubmed ID: 20633027 Robust TLR4-induced Gene Expression Patterns Are Not an Accurate Indicator of Human Immunity Journal of Translational Medicine. 2010 | Pubmed ID: 20105294 Mycobacterium Tuberculosis Cpn60.2 and DnaK Are Located on the Bacterial Surface, Where Cpn60.2 Facilitates Efficient Bacterial Association with Macrophages Infection and Immunity. Aug, 2009 | Pubmed ID: 19470749 Taxon K, a Complex Within the Burkholderia Cepacia Complex, Comprises at Least Two Novel Species, Burkholderia Contaminans Sp. Nov. and Burkholderia Lata Sp. Nov International Journal of Systematic and Evolutionary Microbiology. Jan, 2009 | Pubmed ID: 19126732 ROS-deficient Monocytes Have Aberrant Gene Expression That Correlates with Inflammatory Disorders of Chronic Granulomatous Disease Clinical Immunology (Orlando, Fla.). Oct, 2008 | Pubmed ID: 18676204 Differential Modulation of Innate Immune Cell Functions by the Burkholderia Cepacia Complex: Burkholderia Cenocepacia but Not Burkholderia Multivorans Disrupts Maturation and Induces Necrosis in Human Dendritic Cells Cellular Microbiology. Oct, 2008 | Pubmed ID: 18624797 Differential Mucoid Exopolysaccharide Production by Members of the Burkholderia Cepacia Complex Journal of Clinical Microbiology. Apr, 2008 | Pubmed ID: 18256220 Elucidating Global Epidemiology of Burkholderia Multivorans in Cases of Cystic Fibrosis by Multilocus Sequence Typing Journal of Clinical Microbiology. Jan, 2008 | Pubmed ID: 18032622 Recurrent Systemic Pneumococcal Disease and IRAK4 Deficiency The Pediatric Infectious Disease Journal. Nov, 2007 | Pubmed ID: 17984826 Unique Lipid a Modifications in Pseudomonas Aeruginosa Isolated from the Airways of Patients with Cystic Fibrosis The Journal of Infectious Diseases. Oct, 2007 | Pubmed ID: 17763333 Environmental Burkholderia Cepacia Complex Isolates in Human Infections Emerging Infectious Diseases. Mar, 2007 | Pubmed ID: 17552100 Enhanced Inflammatory Responses of Chronic Granulomatous Disease Leukocytes Involve ROS-independent Activation of NF-kappa B European Journal of Immunology. Apr, 2007 | Pubmed ID: 17330823 Proteomic Identification and Characterization of Bacterial Factors Associated with Burkholderia Cenocepacia Survival in a Murine Host Microbiology (Reading, England). Jan, 2007 | Pubmed ID: 17185549 Reliability of Multilocus Sequence Typing of the Burkholderia Cepacia Complex in Cystic Fibrosis Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society. May, 2007 | Pubmed ID: 17141579 Bacterial Infections of the Lung in Normal and Immunodeficient Patients Novartis Foundation Symposium. 2006 | Pubmed ID: 17278384 IRAK-4 Mutation (Q293X): Rapid Detection and Characterization of Defective Post-transcriptional TLR/IL-1R Responses in Human Myeloid and Non-myeloid Cells Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006 | Pubmed ID: 17114497 Genetic Adaptation by Pseudomonas Aeruginosa to the Airways of Cystic Fibrosis Patients Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16687478 Persistent Bacteremia and Severe Thrombocytopenia Caused by Coagulase-negative Staphylococcus in a Neonatal Intensive Care Unit Pediatrics. Feb, 2006 | Pubmed ID: 16452352 Exopolysaccharides from Burkholderia Cenocepacia Inhibit Neutrophil Chemotaxis and Scavenge Reactive Oxygen Species The Journal of Biological Chemistry. Feb, 2006 | Pubmed ID: 16316987 Multilocus Sequence Typing Scheme That Provides Both Species and Strain Differentiation for the Burkholderia Cepacia Complex Journal of Clinical Microbiology. Sep, 2005 | Pubmed ID: 16145124 Primary Immune Deficiencies Presenting in Adults: Seven Years of Experience from Iran Journal of Clinical Immunology. Jul, 2005 | Pubmed ID: 16133995 Chronic Granulomatous Disease: from Genetic Defect to Clinical Presentation Advances in Experimental Medicine and Biology. 2005 | Pubmed ID: 16107066 Viridans Streptococci Bacteremia in Children with Malignancy: Relevance of Species Identification and Penicillin Susceptibility The Pediatric Infectious Disease Journal. Jun, 2005 | Pubmed ID: 15933573 Identification of DNA Markers for a Transmissible Pseudomonas Aeruginosa Cystic Fibrosis Strain American Journal of Respiratory Cell and Molecular Biology. Jul, 2005 | Pubmed ID: 15834046 Burkholderia Cenocepacia Induces Neutrophil Necrosis in Chronic Granulomatous Disease Journal of Immunology (Baltimore, Md. : 1950). Mar, 2005 | Pubmed ID: 15749893 Burkholderia Phenoliruptrix Sp. Nov., to Accommodate the 2,4,5-trichlorophenoxyacetic Acid and Halophenol-degrading Strain AC1100 Systematic and Applied Microbiology. Nov, 2004 | Pubmed ID: 15612618 Persistence of Burkholderia Multivorans Within the Pulmonary Macrophage in the Murine Lung Infection and Immunity. Oct, 2004 | Pubmed ID: 15385520 Production of Exopolysaccharide by Burkholderia Cenocepacia Results in Altered Cell-surface Interactions and Altered Bacterial Clearance in Mice The Journal of Infectious Diseases. Sep, 2004 | Pubmed ID: 15295701 Burkholderia Cepacia Complex and Cystic Fibrosis: in Search of the Smoking Gun American Journal of Respiratory and Critical Care Medicine. Jul, 2004 | Pubmed ID: 15220120 Differential Post-transcriptional Activation of Human Phagocytes by Different Pseudomonas Aeruginosa Isolates Cellular Microbiology. Jul, 2004 | Pubmed ID: 15186400 Detection and Genotyping of Varicella-zoster Virus by TaqMan Allelic Discrimination Real-time PCR Journal of Clinical Microbiology. Apr, 2004 | Pubmed ID: 15070981 Primary Immunodeficiency to Pneumococcal Infection Due to a Defect in Toll-like Receptor Signaling The Journal of Pediatrics. Apr, 2004 | Pubmed ID: 15069402 The Human Cationic Peptide LL-37 Induces Activation of the Extracellular Signal-regulated Kinase and P38 Kinase Pathways in Primary Human Monocytes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2004 | Pubmed ID: 15004180 The Cationic Antimicrobial Peptide LL-37 Modulates Dendritic Cell Differentiation and Dendritic Cell-induced T Cell Polarization Journal of Immunology (Baltimore, Md. : 1950). Jan, 2004 | Pubmed ID: 14707090 Pseudomonas Aeruginosa: Role in the Pathogenesis of the CF Lung Lesion Seminars in Respiratory and Critical Care Medicine. Dec, 2003 | Pubmed ID: 16088583 Colonial Morphology of Burkholderia Cepacia Complex Genomovar III: Implications in Exopolysaccharide Production, Pilus Expression, and Persistence in the Mouse Infection and Immunity. Feb, 2003 | Pubmed ID: 12540572 Epidemiology of Pseudomonas Aeruginosa in Cystic Fibrosis in British Columbia, Canada American Journal of Respiratory and Critical Care Medicine. Oct, 2002 | Pubmed ID: 12359659 Evaluation of a Diagnostic Polymerase Chain Reaction Assay for Neisseria Meningitidis in North America and Field Experience During an Outbreak Archives of Pathology & Laboratory Medicine. Oct, 2002 | Pubmed ID: 12296761 Biofilm Formation and Acyl Homoserine Lactone Production in the Burkholderia Cepacia Complex Journal of Bacteriology. Oct, 2002 | Pubmed ID: 12270826 Molecular Epidemiology of Pseudomonas Aeruginosa Frontiers in Bioscience : a Journal and Virtual Library. Oct, 2002 | Pubmed ID: 12165481 Effect of Burkholderia Cepacia Infection in the Clinical Course of Patients with Cystic Fibrosis: a Pilot Study in a Sydney Clinic Respirology (Carlton, Vic.). Sep, 2002 | Pubmed ID: 12153690 Multidrug Efflux Systems Play an Important Role in the Invasiveness of Pseudomonas Aeruginosa The Journal of Experimental Medicine. Jul, 2002 | Pubmed ID: 12093875 Burkholderia Anthina Sp. Nov. and Burkholderia Pyrrocinia, Two Additional Burkholderia Cepacia Complex Bacteria, May Confound Results of New Molecular Diagnostic Tools FEMS Immunology and Medical Microbiology. Jun, 2002 | Pubmed ID: 12052570 Differential Persistence Among Genomovars of the Burkholderia Cepacia Complex in a Murine Model of Pulmonary Infection Infection and Immunity. May, 2002 | Pubmed ID: 11953418 Epidemiology of Burkholderia Cepacia Complex in Patients with Cystic Fibrosis, Canada Emerging Infectious Diseases. Feb, 2002 | Pubmed ID: 11897071 Antibiotic Resistance in Pseudomonas Aeruginosa: Mechanisms and Impact on Treatment Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy. Aug, 2000 | Pubmed ID: 11498392 مجموع استخراج بروتين و 2-D طرق جل الكهربائي ل Billie Velapatiño1, James E. A. Zlosnik1, Trevor J. Hird1, David P. Speert1 1Department of Pediatrics, Centre for Understanding and Preventing Infection in Children, University of British Columbia JoVE 50730 Inmunología e infección
مجموع استخراج بروتين و 2-D طرق جل الكهربائي ل Billie Velapatiño1, James E. A. Zlosnik1, Trevor J. Hird1, David P. Speert1 1Department of Pediatrics, Centre for Understanding and Preventing Infection in Children, University of British Columbia JoVE 50730 Inmunología e infección