David Brough Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health University of Manchester Biography Publications Institution JoVE Articles David Brough has not added a biography. If you are David Brough and would like to personalize this page please email our Author Liaison for assistance. Publications Extent of Ischemic Brain Injury After Thrombotic Stroke Is Independent of the NLRP3 (NACHT, LRR and PYD Domains-Containing Protein 3) Inflammasome Stroke. May, 2019 | Pubmed ID: 31009361 Cathelicidin is a "fire Alarm", Generating Protective NLRP3-dependent Airway Epithelial Cell Inflammatory Responses During Infection with Pseudomonas Aeruginosa PLoS Pathogens. Apr, 2019 | Pubmed ID: 30978238 The Three Cytokines IL-1β, IL-18, and IL-1α Share Related but Distinct Secretory Routes The Journal of Biological Chemistry. May, 2019 | Pubmed ID: 30940725 Microglial Priming As Trained Immunity in the Brain Neuroscience. 05, 2019 | Pubmed ID: 29292078 Improving the Gene Ontology Resource to Facilitate More Informative Analysis and Interpretation of Alzheimer's Disease Data Genes. Nov, 2018 | Pubmed ID: 30501127 Small, Thin Graphene Oxide Is Anti-inflammatory Activating Nuclear Factor Erythroid 2-Related Factor 2 Via Metabolic Reprogramming ACS Nano. Dec, 2018 | Pubmed ID: 30444603 Chloride Regulates Dynamic NLRP3-dependent ASC Oligomerization and Inflammasome Priming Proceedings of the National Academy of Sciences of the United States of America. 10, 2018 | Pubmed ID: 30232264 USP7 and USP47 Deubiquitinases Regulate NLRP3 Inflammasome Activation EMBO Reports. 10, 2018 | Pubmed ID: 30206189 Is Targeting the Inflammasome a Way Forward for Neuroscience Drug Discovery? SLAS Discovery : Advancing Life Sciences R & D. Dec, 2018 | Pubmed ID: 29969573 Targeting the IL33-NLRP3 Axis Improves Therapy for Experimental Cerebral Malaria Proceedings of the National Academy of Sciences of the United States of America. 07, 2018 | Pubmed ID: 29954866 Development of a Characterised Tool Kit for the Interrogation of NLRP3 Inflammasome-dependent Responses Scientific Reports. Apr, 2018 | Pubmed ID: 29618797 Redefining the Ancestral Origins of the Interleukin-1 Superfamily Nature Communications. 03, 2018 | Pubmed ID: 29559685 Synthesis and Antibacterial Activities of Enamine Derivatives of Dehydroacetic Acid Medicinal Chemistry Research : an International Journal for Rapid Communications on Design and Mechanisms of Action of Biologically Active Agents. 2018 | Pubmed ID: 29527108 Design, Synthesis and Evaluation of Oxazaborine Inhibitors of the NLRP3 Inflammasome ChemMedChem. 02, 2018 | Pubmed ID: 29331080 Assessing Inflammation in Acute Intracerebral Hemorrhage with PK11195 PET and Dynamic Contrast-Enhanced MRI Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. Mar, 2018 | Pubmed ID: 29064155 CRISPR/Cas9 Mediated Mutation of Mouse IL-1α Nuclear Localisation Sequence Abolishes Expression Scientific Reports. 12, 2017 | Pubmed ID: 29213066 Boron-Based Inhibitors of the NLRP3 Inflammasome Cell Chemical Biology. Nov, 2017 | Pubmed ID: 28943355 An Emerging Case for Membrane Pore Formation As a Common Mechanism for the Unconventional Secretion of FGF2 and IL-1β Journal of Cell Science. Oct, 2017 | Pubmed ID: 28871048 Salmonella Typhimurium-induced IL-1 Release from Primary Human Monocytes Requires NLRP3 and Can Occur in the Absence of Pyroptosis Scientific Reports. 07, 2017 | Pubmed ID: 28761045 Unconventional Pathways of Secretion Contribute to Inflammation International Journal of Molecular Sciences. Jan, 2017 | Pubmed ID: 28067797 Inflammasomes As Therapeutic Targets for Alzheimer's Disease Brain Pathology (Zurich, Switzerland). 03, 2017 | Pubmed ID: 28009077 P2X7 Receptor-dependent Tuning of Gut Epithelial Responses to Infection Immunology and Cell Biology. 02, 2017 | Pubmed ID: 27559003 Fenamate NSAIDs Inhibit the NLRP3 Inflammasome and Protect Against Alzheimer's Disease in Rodent Models Nature Communications. 2016 | Pubmed ID: 27509875 Inflammasomes Link Vascular Disease with Neuroinflammation and Brain Disorders Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 10, 2016 | Pubmed ID: 27486046 Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27221482 Inhibiting the Inflammasome: A Chemical Perspective Journal of Medicinal Chemistry. Mar, 2016 | Pubmed ID: 26422006 Novel Perspectives on Non-canonical Inflammasome Activation ImmunoTargets and Therapy. 2015 | Pubmed ID: 27471719 Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death Frontiers in Immunology. 2015 | Pubmed ID: 26635802 Potassium Efflux Fires the Canon: Potassium Efflux As a Common Trigger for Canonical and Noncanonical NLRP3 Pathways European Journal of Immunology. Oct, 2015 | Pubmed ID: 26332156 Acid-dependent Interleukin-1 (IL-1) Cleavage Limits Available Pro-IL-1β for Caspase-1 Cleavage The Journal of Biological Chemistry. Oct, 2015 | Pubmed ID: 26324708 Interleukin-1 As a Pharmacological Target in Acute Brain Injury Experimental Physiology. Dec, 2015 | Pubmed ID: 26096539 P2X7R Activation Drives Distinct IL-1 Responses in Dendritic Cells Compared to Macrophages Cytokine. Aug, 2015 | Pubmed ID: 26068648 Interleukin-1α and Brain Inflammation IUBMB Life. May, 2015 | Pubmed ID: 25906979 AIM2 and NLRC4 Inflammasomes Contribute with ASC to Acute Brain Injury Independently of NLRP3 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2015 | Pubmed ID: 25775556 Apoptosis-associated Speck-like Protein Containing a CARD Forms Specks but Does Not Activate Caspase-1 in the Absence of NLRP3 During Macrophage Swelling Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25552542 Dendritic Cell IL-1α and IL-1β Are Polyubiquitinated and Degraded by the Proteasome The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25371210 The NLRP3 Inflammasome is Released As a Particulate Danger Signal That Amplifies the Inflammatory Response Nature Immunology. Aug, 2014 | Pubmed ID: 24952504 Release of Interleukin-1α or Interleukin-1β Depends on Mechanism of Cell Death The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24790078 The Role of Inflammation and Interleukin-1 in Acute Cerebrovascular Disease Journal of Inflammation Research. Aug, 2013 | Pubmed ID: 24062616 Acidosis Drives Damage-associated Molecular Pattern (DAMP)-induced Interleukin-1 Secretion Via a Caspase-1-independent Pathway The Journal of Biological Chemistry. Oct, 2013 | Pubmed ID: 24022484 Microglia and Macrophages Differentially Modulate Cell Death After Brain Injury Caused by Oxygen-glucose Deprivation in Organotypic Brain Slices Glia. May, 2013 | Pubmed ID: 23404620 Deubiquitinases Regulate the Activity of Caspase-1 and Interleukin-1β Secretion Via Assembly of the Inflammasome The Journal of Biological Chemistry. Jan, 2013 | Pubmed ID: 23209292 NLRP3-Inflammasome Activating DAMPs Stimulate an Inflammatory Response in Glia in the Absence of Priming Which Contributes to Brain Inflammation After Injury Frontiers in Immunology. 2012 | Pubmed ID: 23024646 Interleukin-1 Receptor Antagonist is Beneficial After Subarachnoid Haemorrhage in Rat by Blocking Haem-driven Inflammatory Pathology Disease Models & Mechanisms. Nov, 2012 | Pubmed ID: 22679224 Inhibition of Calpain Blocks the Phagosomal Escape of Listeria Monocytogenes PloS One. 2012 | Pubmed ID: 22563421 Obese Mice Exhibit an Altered Behavioural and Inflammatory Response to Lipopolysaccharide Disease Models & Mechanisms. Sep, 2012 | Pubmed ID: 22328591 Sphingosine Regulates the NLRP3-inflammasome and IL-1β Release from Macrophages European Journal of Immunology. Mar, 2012 | Pubmed ID: 22105559 Two Zinc Uptake Systems Contribute to the Full Virulence of Listeria Monocytogenes During Growth in Vitro and in Vivo Infection and Immunity. Jan, 2012 | Pubmed ID: 22025520 Interleukin-1α Expression Precedes IL-1β After Ischemic Brain Injury and is Localised to Areas of Focal Neuronal Loss and Penumbral Tissues Journal of Neuroinflammation. Dec, 2011 | Pubmed ID: 22206506 Efficient Discovery of Anti-inflammatory Small-molecule Combinations Using Evolutionary Computing Nature Chemical Biology. Dec, 2011 | Pubmed ID: 22020553 Understanding the Mechanism of IL-1β Secretion Cytokine & Growth Factor Reviews. Aug, 2011 | Pubmed ID: 22019906 Regulation of Interleukin-1 in Acute Brain Injury Trends in Pharmacological Sciences. Oct, 2011 | Pubmed ID: 21788085 Nuclear Retention of IL-1 Alpha by Necrotic Cells: a Mechanism to Dampen Sterile Inflammation European Journal of Immunology. Nov, 2009 | Pubmed ID: 19839011 Pannexin-1-dependent Caspase-1 Activation and Secretion of IL-1beta is Regulated by Zinc European Journal of Immunology. Feb, 2009 | Pubmed ID: 19130485 The Dynamics and Mechanisms of Interleukin-1alpha and Beta Nuclear Import Traffic (Copenhagen, Denmark). Jan, 2009 | Pubmed ID: 18939951 Neuronal Injury Induces the Release of Pro-interleukin-1beta from Activated Microglia in Vitro Brain Research. Oct, 2008 | Pubmed ID: 18722361 A Selective, Non-peptide Caspase-1 Inhibitor, VRT-018858, Markedly Reduces Brain Damage Induced by Transient Ischemia in the Rat Neuropharmacology. Oct, 2007 | Pubmed ID: 17845807 Mechanisms of Regulation for Interleukin-1beta in Neurodegenerative Disease Neuropharmacology. Jun, 2007 | Pubmed ID: 17428507 Caspase-1-dependent Processing of Pro-interleukin-1beta is Cytosolic and Precedes Cell Death Journal of Cell Science. Mar, 2007 | Pubmed ID: 17284521 The Structural Integrity of the Endoplasmic Reticulum, and Its Possible Regulation by Inositol 1,3,4,5-tetrakisphosphate Cell Calcium. Aug, 2005 | Pubmed ID: 16023721 Interleukin-18 Induces Expression and Release of Cytokines from Murine Glial Cells: Interactions with Interleukin-1 Beta Journal of Neurochemistry. Jun, 2003 | Pubmed ID: 12787061 Ca2+ Stores and Ca2+ Entry Differentially Contribute to the Release of IL-1 Beta and IL-1 Alpha from Murine Macrophages Journal of Immunology (Baltimore, Md. : 1950). Mar, 2003 | Pubmed ID: 12626557 Role of P2X7 Receptors in Ischemic and Excitotoxic Brain Injury in Vivo Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2003 | Pubmed ID: 12621313 Extracellular ATP and P2X7 Receptors in Neurodegeneration European Journal of Pharmacology. Jul, 2002 | Pubmed ID: 12151017 Purinergic (P2X7) Receptor Activation of Microglia Induces Cell Death Via an Interleukin-1-independent Mechanism Molecular and Cellular Neurosciences. Feb, 2002 | Pubmed ID: 11860279 Priming of Macrophages with Lipopolysaccharide Potentiates P2X7-mediated Cell Death Via a Caspase-1-dependent Mechanism, Independently of Cytokine Production The Journal of Biological Chemistry. Feb, 2002 | Pubmed ID: 11706016 הייצור של עמילואיד-β-הפרשה Alginate מיקרו חרוזי לשימוש ב דוגמנות מחלת אלצהיימר Bushra Almari1, David Brough2, Michael Harte1, Annalisa Tirella1 1Division of Pharmacy and Optometry, School of Health Studies, Faculty of Biology, Medicine and Health, University of Manchester, 2Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester JoVE 59597 Biología
הייצור של עמילואיד-β-הפרשה Alginate מיקרו חרוזי לשימוש ב דוגמנות מחלת אלצהיימר Bushra Almari1, David Brough2, Michael Harte1, Annalisa Tirella1 1Division of Pharmacy and Optometry, School of Health Studies, Faculty of Biology, Medicine and Health, University of Manchester, 2Division of Neuroscience and Experimental Psychology, School of Biological Sciences, Faculty of Biology, Medicine and Health, University of Manchester JoVE 59597 Biología
