Frederick F. Lang Department of Neurosurgery The University of Texas MD Anderson Cancer Center Biography Publications Institution JoVE Articles Frederick F. Lang has not added a biography. If you are Frederick F. Lang and would like to personalize this page please email our Author Liaison for assistance. Publications Collision Tumor: Multinodular and Vacuolating Neuronal Tumor with Isocitrate Dehydrogenase-mutant Diffuse Astrocytoma Neuropathology : Official Journal of the Japanese Society of Neuropathology. Feb, 2024 | Pubmed ID: 38414131 The Genomic Alterations in Glioblastoma Influence the Levels of CSF Metabolites Acta Neuropathologica Communications. Jan, 2024 | Pubmed ID: 38243318 Triggering Receptor Expressed on Myeloid Cells 2 (TREM2) Regulates Phagocytosis in Glioblastoma Neuro-oncology. Jan, 2024 | Pubmed ID: 38237157 MGMT Function Determines the Differential Response of ATR Inhibitors with DNA-damaging Agents in Glioma Stem Cells for GBM Therapy Neuro-oncology Advances. 2024 | Pubmed ID: 38213834 Rapid Detection of Mutations in CSF-cfTNA with the Genexus Integrated Sequencer Journal of Neuro-oncology. Jan, 2024 | Pubmed ID: 38160230 Tumor-specific Polycistronic MiRNA Delivered by Engineered Exosomes for the Treatment of Glioblastoma Neuro-oncology. Feb, 2024 | Pubmed ID: 37847405 Myeloid-specific KDM6B Inhibition Sensitizes Glioblastoma to PD1 Blockade Nature Cancer. Oct, 2023 | Pubmed ID: 37653141 Multiomics Analyses Reveal /YBX1-controlled Posttranscriptional Circuits Promoting Glioblastoma Tumorigenesis/radioresistance Science Advances. Aug, 2023 | Pubmed ID: 37540752 Adjuvant Therapy with Oncolytic Adenovirus Delta-24-RGDOX After Intratumoral Adoptive T-cell Therapy Promotes Antigen Spread to Sustain Systemic Antitumor Immunity Cancer Research Communications. Jun, 2023 | Pubmed ID: 37379361 Oncolytic DNX-2401 Virotherapy Plus Pembrolizumab in Recurrent Glioblastoma: a Phase 1/2 Trial Nature Medicine. May, 2023 | Pubmed ID: 37188783 Comparison of Pharmacological Inhibitors of Lysine-specific Demethylase 1 in Glioblastoma Stem Cells Reveals Inhibitor-specific Efficacy Profiles Frontiers in Neurology. 2023 | Pubmed ID: 37082446 Changes in Outcomes and Factors Associated with Survival in Melanoma Patients with Brain Metastases Neuro-oncology. Jul, 2023 | Pubmed ID: 36510640 Reshaping the Tumor Microenvironment with Oncolytic Viruses, Positive Regulation of the Immune Synapse, and Blockade of the Immunosuppressive Oncometabolic Circuitry Journal for Immunotherapy of Cancer. Jul, 2022 | Pubmed ID: 35902132 An Interdisciplinary Consensus on the Management of Brain Metastases in Patients with Renal Cell Carcinoma CA: a Cancer Journal for Clinicians. Sep, 2022 | Pubmed ID: 35708940 A Window of Opportunity to Overcome Therapeutic Failure in Neuro-Oncology American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Annual Meeting. Apr, 2022 | Pubmed ID: 35580289 Preclinical Animal Brain Tumor Models for Interventional Neuro-oncology Journal of Neurointerventional Surgery. May, 2022 | Pubmed ID: 35414632 Convection Enhanced Delivery of the Oncolytic Adenovirus Delta24-RGD in Patients with Recurrent GBM: A Phase I Clinical Trial Including Correlative Studies Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2022 | Pubmed ID: 35176144 Single-cell Analysis of Human Glioma and Immune Cells Identifies S100A4 As an Immunotherapy Target Nature Communications. Feb, 2022 | Pubmed ID: 35140215 Long Term Outcomes Following Surgery for Pineal Region Tumors Journal of Neuro-oncology. Feb, 2022 | Pubmed ID: 35083579 Circumferential Sulcus-guided Resection Technique for Improved Outcomes of Low-grade Gliomas Journal of Neurosurgery. Jan, 2022 | Pubmed ID: 34996044 Perfusion-guided Endovascular Super-selective Intra-arterial Infusion for Treatment of Malignant Brain Tumors Journal of Neurointerventional Surgery. Jun, 2022 | Pubmed ID: 34824133 Characterization of Patient-derived Bone Marrow Human Mesenchymal Stem Cells As Oncolytic Virus Carriers for the Treatment of Glioblastoma Journal of Neurosurgery. Mar, 2022 | Pubmed ID: 34450587 Inhibition of Nicotinamide Phosphoribosyltransferase (NAMPT), the Rate-limiting Enzyme of the Nicotinamide Adenine Dinucleotide (NAD) Salvage Pathway, to Target Glioma Heterogeneity Through Mitochondrial Oxidative Stress Neuro-oncology. Feb, 2022 | Pubmed ID: 34260721 NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors Reports (MDPI). Dec, 2021 | Pubmed ID: 35937580 Intrinsic Interferon Signaling Regulates the Cell Death and Mesenchymal Phenotype of Glioblastoma Stem Cells Cancers. Oct, 2021 | Pubmed ID: 34771447 Measuring the Metabolic Evolution of Glioblastoma Throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance Cells. Oct, 2021 | Pubmed ID: 34685601 Hitchhiking to Brain Tumours: Stem Cell Delivery of Oncolytic Viruses The Lancet. Oncology. Aug, 2021 | Pubmed ID: 34214494 Targeting the αv Integrin/TGF-β Axis Improves Natural Killer Cell Function Against Glioblastoma Stem Cells The Journal of Clinical Investigation. Jul, 2021 | Pubmed ID: 34138753 An Immune-competent, Replication-permissive Syrian Hamster Glioma Model for Evaluating Delta-24-RGD Oncolytic Adenovirus Neuro-oncology. Nov, 2021 | Pubmed ID: 34059921 Medium-Chain Acyl-CoA Dehydrogenase Protects Mitochondria from Lipid Peroxidation in Glioblastoma Cancer Discovery. Nov, 2021 | Pubmed ID: 34039636 The History of Neurosurgery at Baylor College of Medicine Journal of Neurosurgery. Feb, 2021 | Pubmed ID: 33607618 Delta-24 Adenoviral Therapy for Glioblastoma: Evolution from the Bench to Bedside and Future Considerations Neurosurgical Focus. Feb, 2021 | Pubmed ID: 33524949 Intraarterial Delivery of Virotherapy for Glioblastoma Neurosurgical Focus. Feb, 2021 | Pubmed ID: 33524944 Considerations for Designing Preclinical Cancer Immune Nanomedicine Studies Nature Nanotechnology. Jan, 2021 | Pubmed ID: 33349682 Window of Opportunity Clinical Trials to Evaluate Novel Therapies for Brain Tumors Neurosurgery Clinics of North America. Jan, 2021 | Pubmed ID: 33223031 RNAi Technology Targeting the Fusion Breakpoint: an Opportunity for Precision Medicine Neuro-oncology Advances. 2020 | Pubmed ID: 33241214 Impact of Anesthesia and Analgesia Techniques on Glioblastoma Progression. A Narrative Review Neuro-oncology Advances. 2020 | Pubmed ID: 33205044 Profiling of Patients with Glioma Reveals the Dominant Immunosuppressive Axis is Refractory to Immune Function Restoration JCI Insight. Sep, 2020 | Pubmed ID: 32721947 The Role of Resting-state Functional MRI for Clinical Preoperative Language Mapping Cancer Imaging : the Official Publication of the International Cancer Imaging Society. Jul, 2020 | Pubmed ID: 32653026 A Cancer Drug Atlas Enables Synergistic Targeting of Independent Drug Vulnerabilities Nature Communications. Jun, 2020 | Pubmed ID: 32523045 Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2020 | Pubmed ID: 32299815 Circadian Regulator CLOCK Recruits Immune-Suppressive Microglia into the GBM Tumor Microenvironment Cancer Discovery. Mar, 2020 | Pubmed ID: 31919052 Window-of-opportunity Clinical Trial of Pembrolizumab in Patients with Recurrent Glioblastoma Reveals Predominance of Immune-suppressive Macrophages Neuro-oncology. Apr, 2020 | Pubmed ID: 31755915 Advances in Endovascular Neuro-oncology: Endovascular Selective Intra-arterial (ESIA) Infusion of Targeted Biologic Therapy for Brain Tumors Journal of Neurointerventional Surgery. Feb, 2020 | Pubmed ID: 31676690 Perilesional Resection of Glioblastoma Is Independently Associated With Improved Outcomes Neurosurgery. Jan, 2020 | Pubmed ID: 30799490 GITRL-armed Delta-24-RGD Oncolytic Adenovirus Prolongs Survival and Induces Anti-glioma Immune Memory Neuro-oncology Advances. 2019 | Pubmed ID: 31608328 Microcatheter Delivery of Neurotherapeutics: Compatibility with Mesenchymal Stem Cells Journal of Neurosurgery. Sep, 2019 | Pubmed ID: 31491769 Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity Against Disseminated Subcutaneous and Intracranial Melanomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2019 | Pubmed ID: 31455679 REST-DRD2 Mechanism Impacts Glioblastoma Stem Cell-mediated Tumorigenesis Neuro-oncology. Jun, 2019 | Pubmed ID: 30953587 Biological Subtypes and Survival Outcomes in Breast Cancer Patients with Brain Metastases in the Targeted Therapy Era Neuro-oncology Practice. Aug, 2018 | Pubmed ID: 31386016 Distinct Mechanisms Enable Inward or Outward Budding from Late Endosomes/multivesicular Bodies Experimental Cell Research. Nov, 2018 | Pubmed ID: 30144444 A Coclinical Radiogenomic Validation Study: Conserved Magnetic Resonance Radiomic Appearance of Periostin-Expressing Glioblastoma in Patients and Xenograft Models Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2018 | Pubmed ID: 30054278 MRI Venous Architecture of Insula Journal of the Neurological Sciences. Jul, 2018 | Pubmed ID: 29801878 A Gene Expression Signature Predicts Recurrence-free Survival in Meningioma Oncotarget. Mar, 2018 | Pubmed ID: 29662628 Magnetic Resonance and Photoacoustic Imaging of Brain Tumor Mediated by Mesenchymal Stem Cell Labeled with Multifunctional Nanoparticle Introduced Via Carotid Artery Injection Nanotechnology. Apr, 2018 | Pubmed ID: 29438105 Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. May, 2018 | Pubmed ID: 29432077 Dexamethasone-mediated Oncogenicity in Vitro and in an Animal Model of Glioblastoma Journal of Neurosurgery. Dec, 2018 | Pubmed ID: 29328002 Mesenchymal Stem Cells As Natural Biofactories for Exosomes Carrying MiR-124a in the Treatment of Gliomas Neuro-oncology. Feb, 2018 | Pubmed ID: 29016843 Ionizing Radiation Augments Glioma Tropism of Mesenchymal Stem Cells Journal of Neurosurgery. Jan, 2018 | Pubmed ID: 28362237 Exosomes from Glioma-Associated Mesenchymal Stem Cells Increase the Tumorigenicity of Glioma Stem-like Cells Via Transfer of MiR-1587 Cancer Research. Nov, 2017 | Pubmed ID: 28855213 TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation Molecular and Cellular Biology. Nov, 2017 | Pubmed ID: 28760776 Post-operative Stereotactic Radiosurgery Versus Observation for Completely Resected Brain Metastases: a Single-centre, Randomised, Controlled, Phase 3 Trial The Lancet. Oncology. Aug, 2017 | Pubmed ID: 28687375 Efficacy of Onalespib, a Long-Acting Second-Generation HSP90 Inhibitor, As a Single Agent and in Combination with Temozolomide Against Malignant Gliomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2017 | Pubmed ID: 28679777 Oncolytic Adenovirus and Tumor-Targeting Immune Modulatory Therapy Improve Autologous Cancer Vaccination Cancer Research. Jul, 2017 | Pubmed ID: 28566332 Mesenchymal Stromal Cells for the Delivery of Oncolytic Viruses in Gliomas Cytotherapy. Apr, 2017 | Pubmed ID: 28233640 Preclinical Evaluation of Sequential Combination of Oncolytic Adenovirus Delta-24-RGD and Phosphatidylserine-Targeting Antibody in Pancreatic Ductal Adenocarcinoma Molecular Cancer Therapeutics. Apr, 2017 | Pubmed ID: 28138026 A Dexamethasone-regulated Gene Signature Is Prognostic for Poor Survival in Glioblastoma Patients Journal of Neurosurgical Anesthesiology. Jan, 2017 | Pubmed ID: 27653222 TIE2-mediated Tyrosine Phosphorylation of H4 Regulates DNA Damage Response by Recruiting ABL1 Science Advances. Apr, 2016 | Pubmed ID: 27757426 Endoplasmic Reticulum Stress-inducing Drugs Sensitize Glioma Cells to Temozolomide Through Downregulation of MGMT, MPG, and Rad51 Neuro-oncology. Aug, 2016 | Pubmed ID: 26951384 Suppression of RAF/MEK or PI3K Synergizes Cytotoxicity of Receptor Tyrosine Kinase Inhibitors in Glioma Tumor-initiating Cells Journal of Translational Medicine. Feb, 2016 | Pubmed ID: 26861698 Genetic, Epigenetic, and Molecular Landscapes of Multifocal and Multicentric Glioblastoma Acta Neuropathologica. Oct, 2015 | Pubmed ID: 26323991 Integrated Transcriptomic and Glycomic Profiling of Glioma Stem Cell Xenografts Journal of Proteome Research. Sep, 2015 | Pubmed ID: 26185906 Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway Stem Cells (Dayton, Ohio). Aug, 2015 | Pubmed ID: 25966666 ESI-MS/MS and MALDI-IMS Localization Reveal Alterations in Phosphatidic Acid, Diacylglycerol, and DHA in Glioma Stem Cell Xenografts Journal of Proteome Research. Jun, 2015 | Pubmed ID: 25880480 Oncolytic Adenovirus Research Evolution: from Cell-cycle Checkpoints to Immune Checkpoints Current Opinion in Virology. Aug, 2015 | Pubmed ID: 25863716 FoxM1 Drives a Feed-Forward STAT3-Activation Signaling Loop That Promotes the Self-Renewal and Tumorigenicity of Glioblastoma Stem-like Cells Cancer Research. Jun, 2015 | Pubmed ID: 25832656 Two Mature Products of MIR-491 Coordinate to Suppress Key Cancer Hallmarks in Glioblastoma Oncogene. Mar, 2015 | Pubmed ID: 24747968 A History of the AANS/CNS Section on Tumors Biennial Satellite Symposium Journal of Neuro-oncology. Sep, 2014 | Pubmed ID: 25081975 Delta-24-RGD Oncolytic Adenovirus Elicits Anti-glioma Immunity in an Immunocompetent Mouse Model PloS One. 2014 | Pubmed ID: 24827739 Extent of Resection of Glioblastoma Revisited: Personalized Survival Modeling Facilitates More Accurate Survival Prediction and Supports a Maximum-safe-resection Approach to Surgery Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2014 | Pubmed ID: 24516010 A High Notch Pathway Activation Predicts Response to γ Secretase Inhibitors in Proneural Subtype of Glioma Tumor-initiating Cells Stem Cells (Dayton, Ohio). Jan, 2014 | Pubmed ID: 24038660 MiR-124 Inhibits STAT3 Signaling to Enhance T Cell-mediated Immune Clearance of Glioma Cancer Research. Jul, 2013 | Pubmed ID: 23636127 A Prospective Randomized Trial of Perioperative Seizure Prophylaxis in Patients with Intraparenchymal Brain Tumors Journal of Neurosurgery. Apr, 2013 | Pubmed ID: 23394340 TGF-β Mediates Homing of Bone Marrow-derived Human Mesenchymal Stem Cells to Glioma Stem Cells Cancer Research. Apr, 2013 | Pubmed ID: 23365134 REST Regulates Oncogenic Properties of Glioblastoma Stem Cells Stem Cells (Dayton, Ohio). Mar, 2012 | Pubmed ID: 22228704 Genetic and Epigenetic Modifications of Sox2 Contribute to the Invasive Phenotype of Malignant Gliomas PloS One. 2011 | Pubmed ID: 22069467 High Rate of Deletion of Chromosomes 1p and 19q in Insular Oligodendroglial Tumors Journal of Neuro-oncology. Aug, 2010 | Pubmed ID: 20035368 Targeting Gelatinases with a Near-infrared Fluorescent Cyclic His-Try-Gly-Phe Peptide Molecular Imaging and Biology. 2009 | Pubmed ID: 19424760 Delta-24-RGD in Combination with RAD001 Induces Enhanced Anti-glioma Effect Via Autophagic Cell Death Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2008 | Pubmed ID: 18253154 Diffusely Infiltrative Low-grade Gliomas in Adults Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2006 | Pubmed ID: 16525178 Delta24-hyCD Adenovirus Suppresses Glioma Growth in Vivo by Combining Oncolysis and Chemosensitization Cancer Gene Therapy. Mar, 2005 | Pubmed ID: 15650766 Prospective Clinical Trials of Brain Tumor Therapy: the Critical Role of Neurosurgeons Journal of Neuro-oncology. 2004 | Pubmed ID: 15527087 A Novel E1A-E1B Mutant Adenovirus Induces Glioma Regression in Vivo Oncogene. Mar, 2004 | Pubmed ID: 15014451 Phase I Trial of Adenovirus-mediated P53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2003 | Pubmed ID: 12839017 Toward Better Early-phase Brain Tumor Clinical Trials: a Reappraisal of Current Methods and Proposals for Future Strategies Neuro-oncology. Oct, 2002 | Pubmed ID: 12356357 Surgical Resection of Intrinsic Insular Tumors: Complication Avoidance Journal of Neurosurgery. Oct, 2001 | Pubmed ID: 11596959 Author Spotlight: Advancing Glioblastoma Treatment Through Intraarterial Delivery Strategies for Oncolytic Viruses and MicroRNAs Daniel Ledbetter1, Joy Gumin1, Lynette Phillips1, Chibawanye Ene1, Yuzaburo Shimizu1,2, Frederick F. Lang1 1Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 2Department of Neurosurgery, Juntendo University JoVE 66303 Investigación sobre el cáncer
Author Spotlight: Advancing Glioblastoma Treatment Through Intraarterial Delivery Strategies for Oncolytic Viruses and MicroRNAs Daniel Ledbetter1, Joy Gumin1, Lynette Phillips1, Chibawanye Ene1, Yuzaburo Shimizu1,2, Frederick F. Lang1 1Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, 2Department of Neurosurgery, Juntendo University JoVE 66303 Investigación sobre el cáncer