Herbert Levine Department of Bioengineering Rice University Biography Publications Institution JoVE Articles Herbert Levine has not added a biography. If you are Herbert Levine and would like to personalize this page please email our Author Liaison for assistance. Publications Phosphorylation-induced Conformational Dynamics in an Intrinsically Disordered Protein and Potential Role in Phenotypic Heterogeneity Proceedings of the National Academy of Sciences of the United States of America. Mar, 2017 | Pubmed ID: 28289210 The GRHL2/ZEB Feedback Loop - A Key Axis in the Regulation of EMT in Breast Cancer Journal of Cellular Biochemistry. Mar, 2017 | Pubmed ID: 28266048 Crawling and Turning in a Minimal Reaction-diffusion Cell Motility Model: Coupling Cell Shape and Biochemistry Physical Review. E. Jan, 2017 | Pubmed ID: 28208438 Modeling the Genetic Regulation of Cancer Metabolism: Interplay Between Glycolysis and Oxidative Phosphorylation Cancer Research. Feb, 2017 | Pubmed ID: 28202516 Mechanical Bounds to Transcriptional Noise Proceedings of the National Academy of Sciences of the United States of America. Dec, 2016 | Pubmed ID: 27911801 Modeling Delayed Processes in Biological Systems Physical Review. E. Sep, 2016 | Pubmed ID: 27739721 Expanding the Scale of Molecular Biophysics Physical Biology. Oct, 2016 | Pubmed ID: 27716638 Phenotypic Plasticity in Prostate Cancer: Role of Intrinsically Disordered Proteins Asian Journal of Andrology. Sep-Oct, 2016 | Pubmed ID: 27427552 Mesenchymal-Epithelial Transition in Sarcomas Is Controlled by the Combinatorial Expression of MicroRNA 200s and GRHL2 Molecular and Cellular Biology. Oct, 2016 | Pubmed ID: 27402864 Collective Signal Processing in Cluster Chemotaxis: Roles of Adaptation, Amplification, and Co-attraction in Collective Guidance PLoS Computational Biology. Jul, 2016 | Pubmed ID: 27367541 Notch-Jagged Signalling Can Give Rise to Clusters of Cells Exhibiting a Hybrid Epithelial/mesenchymal Phenotype Journal of the Royal Society, Interface. May, 2016 | Pubmed ID: 27170649 Tumor Budding: The Name is EMT. Partial EMT Journal of Clinical Medicine. Apr, 2016 | Pubmed ID: 27136592 Stability of the Hybrid Epithelial/mesenchymal Phenotype Oncotarget. Mar, 2016 | Pubmed ID: 27008704 Emergent Collective Chemotaxis Without Single-Cell Gradient Sensing Physical Review Letters. Mar, 2016 | Pubmed ID: 26991203 Immunoproteasome Deficiency is a Feature of Non-small Cell Lung Cancer with a Mesenchymal Phenotype and is Associated with a Poor Outcome Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26929325 Contact Inhibition of Locomotion Determines Cell-cell and Cell-substrate Forces in Tissues Proceedings of the National Academy of Sciences of the United States of America. Mar, 2016 | Pubmed ID: 26903658 Modeling Closure of Circular Wounds Through Coordinated Collective Motion Physical Biology. Feb, 2016 | Pubmed ID: 26871883 Excitable Waves and Direction-sensing in Dictyostelium Discoideum: Steps Towards a Chemotaxis Model Physical Biology. Jan, 2016 | Pubmed ID: 26824302 Nonlinear Elasticity of Disordered Fiber Networks Soft Matter. Feb, 2016 | Pubmed ID: 26616428 Scaling Solution in the Large Population Limit of the General Asymmetric Stochastic Luria-Delbrück Evolution Process Journal of Statistical Physics. Feb, 2015 | Pubmed ID: 26900175 The Motility-proliferation-metabolism Interplay During Metastatic Invasion Scientific Reports. Sep, 2015 | Pubmed ID: 26337223 Micromechanics of Cellularized Biopolymer Networks Proceedings of the National Academy of Sciences of the United States of America. Sep, 2015 | Pubmed ID: 26324923 Coupling the Modules of EMT and Stemness: A Tunable 'stemness Window' Model Oncotarget. Sep, 2015 | Pubmed ID: 26317796 Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis Frontiers in Oncology. 2015 | Pubmed ID: 26258068 Properties of Cooperatively Induced Phases in Sensing Models Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. May, 2015 | Pubmed ID: 26066199 Alignment and Nonlinear Elasticity in Biopolymer Gels Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Apr, 2015 | Pubmed ID: 25974530 OVOL Guides the Epithelial-hybrid-mesenchymal Transition Oncotarget. Jun, 2015 | Pubmed ID: 25944618 Mechanically-driven Phase Separation in a Growing Bacterial Colony Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015 | Pubmed ID: 25870260 Connecting Thermal and Mechanical Protein (un)folding Landscapes Biophysical Journal. Dec, 2014 | Pubmed ID: 25517160 Towards Elucidating the Connection Between Epithelial-mesenchymal Transitions and Stemness Journal of the Royal Society, Interface / the Royal Society. Dec, 2014 | Pubmed ID: 25339690 How Input Noise Limits Biochemical Sensing in Ultrasensitive Systems Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Sep, 2014 | Pubmed ID: 25314468 Learning Physics of Living Systems from Dictyostelium Physical Biology. Oct, 2014 | Pubmed ID: 25294248 Polarity Mechanisms Such As Contact Inhibition of Locomotion Regulate Persistent Rotational Motion of Mammalian Cells on Micropatterns Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25258412 Cellular Memory in Eukaryotic Chemotaxis Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25249632 Resistance to Chemotherapy: Patient Variability and Cellular Heterogeneity Cancer Research. Sep, 2014 | Pubmed ID: 25183790 Introduction to Physics in Cancer Research Cancer Research. Sep, 2014 | Pubmed ID: 25183782 Intercellular Stress Reconstitution from Traction Force Data Biophysical Journal. Aug, 2014 | Pubmed ID: 25099794 Physical Biology : Challenges for Our Second Decade Physical Biology. Jun, 2014 | Pubmed ID: 24732666 Toward Rationally Redesigning Bacterial Two-component Signaling Systems Using Coevolutionary Information Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24449878 Growth Feedback As a Basis for Persister Bistability Proceedings of the National Academy of Sciences of the United States of America. Jan, 2014 | Pubmed ID: 24344277 The Physics of Eukaryotic Chemotaxis Physics Today. Feb, 2013 | Pubmed ID: 24363460 Modeling Cell-death Patterning During Biofilm Formation Physical Biology. Dec, 2013 | Pubmed ID: 24275528 Periodic Migration in a Physical Model of Cells on Micropatterns Physical Review Letters. Oct, 2013 | Pubmed ID: 24160631 MicroRNA-based Regulation of Epithelial-hybrid-mesenchymal Fate Determination Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24154725 Scientific Priorities for the BRAIN Initiative Nature Methods. Aug, 2013 | Pubmed ID: 23900253 We Need Theoretical Physics Approaches to Study Living Systems Physical Biology. Aug, 2013 | Pubmed ID: 23883648 Energy Evaluation of β-strand Packing in a Fibril-forming SH3 Domain The Journal of Physical Chemistry. B. Oct, 2013 | Pubmed ID: 23819485 Large Population Solution of the Stochastic Luria-Delbruck Evolution Model Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23818583 Alignment of Cellular Motility Forces with Tissue Flow As a Mechanism for Efficient Wound Healing Proceedings of the National Academy of Sciences of the United States of America. Feb, 2013 | Pubmed ID: 23345440 How Input Fluctuations Reshape the Dynamics of a Biological Switching System Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Dec, 2012 | Pubmed ID: 23367979 Short-term Plasticity Constrains Spatial Organization of a Hippocampal Presynaptic Terminal Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22908295 Bacterial Survival Strategies Suggest Rethinking Cancer Cooperativity Trends in Microbiology. Sep, 2012 | Pubmed ID: 22750098 Coupling Actin Flow, Adhesion, and Morphology in a Computational Cell Motility Model Proceedings of the National Academy of Sciences of the United States of America. May, 2012 | Pubmed ID: 22493219 Noise Effects in Nonlinear Biochemical Signaling Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Jan, 2012 | Pubmed ID: 22400585 Incoherent Feedforward Control Governs Adaptation of Activated Ras in a Eukaryotic Chemotaxis Pathway Science Signaling. Jan, 2012 | Pubmed ID: 22215733 Effects of Input Noise on a Simple Biochemical Switch Physical Review Letters. Sep, 2011 | Pubmed ID: 22107236 Propagating Mode-I Fracture in Amorphous Materials Using the Continuous Random Network Model Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Aug, 2011 | Pubmed ID: 21929059 "Self-assisted" Amoeboid Navigation in Complex Environments PloS One. 2011 | Pubmed ID: 21829602 Activated Membrane Patches Guide Chemotactic Cell Motility PLoS Computational Biology. Jun, 2011 | Pubmed ID: 21738453 Quantifying Information Transmission in Eukaryotic Gradient Sensing and Chemotactic Response Journal of Statistical Physics. Apr, 2011 | Pubmed ID: 21643513 How Geometry and Internal Bias Affect the Accuracy of Eukaryotic Gradient Sensing Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Feb, 2011 | Pubmed ID: 21405873 Design Principles and Specificity in Biological Networks with Cross Activation Physical Biology. Apr, 2011 | Pubmed ID: 21263168 Modelling Vesicular Release at Hippocampal Synapses PLoS Computational Biology. Nov, 2010 | Pubmed ID: 21085682 Shunting Inhibition Controls the Gain Modulation Mediated by Asynchronous Neurotransmitter Release in Early Development PLoS Computational Biology. Nov, 2010 | Pubmed ID: 21079676 Gradient Sensing in Defined Chemotactic Fields Integrative Biology : Quantitative Biosciences from Nano to Macro. Nov, 2010 | Pubmed ID: 20882228 Physical Limits on Cellular Sensing of Spatial Gradients Physical Review Letters. Jul, 2010 | Pubmed ID: 20867888 Computational Model for Cell Morphodynamics Physical Review Letters. Sep, 2010 | Pubmed ID: 20867552 Optimal Strategy for Competence Differentiation in Bacteria PLoS Genetics. Sep, 2010 | Pubmed ID: 20838595 The Role of Cell Contraction and Adhesion in Dictyostelium Motility Biophysical Journal. Jul, 2010 | Pubmed ID: 20655832 A Comparison of Deterministic and Stochastic Simulations of Neuronal Vesicle Release Models Physical Biology. May, 2010 | Pubmed ID: 20505227 Transient Localized Patterns in Noise-driven Reaction-diffusion Systems Physical Review Letters. Apr, 2010 | Pubmed ID: 20482022 External and Internal Constraints on Eukaryotic Chemotaxis Proceedings of the National Academy of Sciences of the United States of America. May, 2010 | Pubmed ID: 20457897 Phenomenological Approach to Eukaryotic Chemotactic Efficiency Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Mar, 2010 | Pubmed ID: 20365769 Compartmentalization of Second Messengers in Neurons: a Mathematical Analysis Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Oct, 2009 | Pubmed ID: 19905336 Signal Processing in Local Neuronal Circuits Based on Activity-dependent Noise and Competition Chaos (Woodbury, N.Y.). Sep, 2009 | Pubmed ID: 19791987 Locally Balanced Dendritic Integration by Short-term Synaptic Plasticity and Active Dendritic Conductances Journal of Neurophysiology. Dec, 2009 | Pubmed ID: 19759328 Mechanisms and Constraints on Yeast MAPK Signaling Specificity Biophysical Journal. Jun, 2009 | Pubmed ID: 19527636 Determining the Scale of the Bicoid Morphogen Gradient Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19190186 The Fixation Probability of Rare Mutators in Finite Asexual Populations Genetics. Apr, 2009 | Pubmed ID: 19153261 Multimodal Encoding in a Simplified Model of Intracellular Calcium Signaling Cognitive Processing. Feb, 2009 | Pubmed ID: 19030904 A Mathematical Analysis of Second Messenger Compartmentalization Physical Biology. Dec, 2008 | Pubmed ID: 19075354 Receptor Noise Limitations on Chemotactic Sensing Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19064934 Receptor Noise and Directional Sensing in Eukaryotic Chemotaxis Physical Review Letters. Jun, 2008 | Pubmed ID: 18643461 Activity-dependent Stochastic Resonance in Recurrent Neuronal Networks Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Jun, 2008 | Pubmed ID: 18643209 Coexistence of Amplitude and Frequency Modulations in Intracellular Calcium Dynamics Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Mar, 2008 | Pubmed ID: 18517322 Astrocytes Optimize the Synaptic Transmission of Information PLoS Computational Biology. May, 2008 | Pubmed ID: 18516277 Small Regulatory RNAs May Sharpen Spatial Expression Patterns PLoS Computational Biology. Nov, 2007 | Pubmed ID: 18052540 Correlated Phenotypic Transitions to Competence in Bacterial Colonies Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Oct, 2007 | Pubmed ID: 17994927 Target-specific and Global Effectors in Gene Regulation by MicroRNA Biophysical Journal. Dec, 2007 | Pubmed ID: 17872959 Folding Time Predictions from All-atom Replica Exchange Simulations Journal of Molecular Biology. Sep, 2007 | Pubmed ID: 17681536 Quantifying Noise Levels of Intercellular Signals Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Jun, 2007 | Pubmed ID: 17677298 The Astrocyte As a Gatekeeper of Synaptic Information Transfer Neural Computation. Feb, 2007 | Pubmed ID: 17206866 Effective Stochastic Dynamics on a Protein Folding Energy Landscape The Journal of Chemical Physics. Aug, 2006 | Pubmed ID: 16942260 Fluctuation-induced Instabilities in Front Propagation Up a Comoving Reaction Gradient in Two Dimensions Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Jul, 2006 | Pubmed ID: 16907163 Self-engineering Capabilities of Bacteria Journal of the Royal Society, Interface / the Royal Society. Feb, 2006 | Pubmed ID: 16849231 Embryonic Pattern Scaling Achieved by Oppositely Directed Morphogen Gradients Physical Biology. May, 2006 | Pubmed ID: 16829697 Directional Sensing in Eukaryotic Chemotaxis: a Balanced Inactivation Model Proceedings of the National Academy of Sciences of the United States of America. Jun, 2006 | Pubmed ID: 16782813 Analytic Approach to the Evolutionary Effects of Genetic Exchange Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Jan, 2006 | Pubmed ID: 16486222 Division Accuracy in a Stochastic Model of Min Oscillations in Escherichia Coli Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006 | Pubmed ID: 16387859 Front Propagation Up a Reaction Rate Gradient Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Dec, 2005 | Pubmed ID: 16486029 Membrane-bound Turing Patterns Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Dec, 2005 | Pubmed ID: 16485979 Structure of Infectious Prions: Stabilization by Domain Swapping FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2005 | Pubmed ID: 16260647 Excitation-contraction Coupling Gain and Cooperativity of the Cardiac Ryanodine Receptor: a Modeling Approach Biophysical Journal. Nov, 2005 | Pubmed ID: 16126827 Protein Oligomerization Through Domain Swapping: Role of Inter-molecular Interactions and Protein Concentration Journal of Molecular Biology. Sep, 2005 | Pubmed ID: 16061250 Fluctuation-regularized Front Propagation Dynamics in Reaction-diffusion Systems Physical Review Letters. Apr, 2005 | Pubmed ID: 15904196 Recombination Dramatically Speeds Up Evolution of Finite Populations Physical Review Letters. Mar, 2005 | Pubmed ID: 15784005 Cooperativity Can Reduce Stochasticity in Intracellular Calcium Dynamics Physical Biology. Jun, 2004 | Pubmed ID: 16204819 Physical Schemata Underlying Biological Pattern Formation-examples, Issues and Strategies Physical Biology. Jun, 2004 | Pubmed ID: 16204813 Dynamic Instabilities of Fracture Under Biaxial Strain Using a Phase Field Model Physical Review Letters. Sep, 2004 | Pubmed ID: 15447417 Domain Swapping is a Consequence of Minimal Frustration Proceedings of the National Academy of Sciences of the United States of America. Sep, 2004 | Pubmed ID: 15361578 Bacterial Linguistic Communication and Social Intelligence Trends in Microbiology. Aug, 2004 | Pubmed ID: 15276612 Analytical Study of the Effect of Recombination on Evolution Via DNA Shuffling Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. May, 2004 | Pubmed ID: 15244851 Computational Approach for Modeling Intra- and Extracellular Dynamics Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Sep, 2003 | Pubmed ID: 14524934 Does the Continuum Theory of Dynamic Fracture Work? Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Sep, 2003 | Pubmed ID: 14524843 Wave Nucleation Rate in Excitable Systems in the Low Noise Limit Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Sep, 2003 | Pubmed ID: 14524810 Dynamics of Competitive Evolution on a Smooth Landscape Physical Review Letters. Feb, 2003 | Pubmed ID: 12633464 Comment on "dynamics of HIV Infection: a Cellular Automata Approach" Physical Review Letters. Nov, 2002 | Pubmed ID: 12443459 Spectral Mixing of Rhythmic Neuronal Signals in Sensory Cortex Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12403828 Mode-I Fracture in a Nonlinear Lattice with Viscoelastic Forces Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Jul, 2002 | Pubmed ID: 12241445 Establishing Direction During Chemotaxis in Eukaryotic Cells Biophysical Journal. Sep, 2002 | Pubmed ID: 12202361 Modeling Spatial Patterns in Dictyostelium Chaos (Woodbury, N.Y.). Sep, 1994 | Pubmed ID: 12780133 Coupled Map Lattice Techniques for Simulating Interfacial Phenomena in Reaction-diffusion Systems Chaos (Woodbury, N.Y.). Jul, 1992 | Pubmed ID: 12779983 Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells Kathryn E. Ware1, Shivee Gilja1, Shenghan Xu1, Samantha Shetler1, Mohit K. Jolly2, Xueyang Wang3, Suzanne Bartholf Dewitt4, Alexander J. Hish1, Sarah Jordan1, William Eward5, Herbert Levine2, Andrew J. Armstrong4, Jason A. Somarelli1 1Department of Medicine, Duke University, 2Department of Bioengineering, Rice University, 3Department of Molecular Genetics and Microbiology, Duke University, 4Solid Tumor Program and the Duke Prostate Center, Duke University Medical Center, 5Duke University Medical Center JoVE 55520 Biología del desarrollo
Induction of Mesenchymal-Epithelial Transitions in Sarcoma Cells Kathryn E. Ware1, Shivee Gilja1, Shenghan Xu1, Samantha Shetler1, Mohit K. Jolly2, Xueyang Wang3, Suzanne Bartholf Dewitt4, Alexander J. Hish1, Sarah Jordan1, William Eward5, Herbert Levine2, Andrew J. Armstrong4, Jason A. Somarelli1 1Department of Medicine, Duke University, 2Department of Bioengineering, Rice University, 3Department of Molecular Genetics and Microbiology, Duke University, 4Solid Tumor Program and the Duke Prostate Center, Duke University Medical Center, 5Duke University Medical Center JoVE 55520 Biología del desarrollo