Jeremy C. Simpson Cell Screening Laboratory, UCD School of Biology and Environmental Science University College Dublin Biography Publications Institution JoVE Articles Jeremy C. Simpson has not added a biography. If you are Jeremy C. Simpson and would like to personalize this page please email our Author Liaison for assistance. Publications Cell3: a New Vision for Study of the Endomembrane System in Mammalian Cells Bioscience Reports. Dec, 2021 | Pubmed ID: 34874399 Cell3: A New Vision for Study of the Endomembrane System in Mammalian Cells Bioscience Reports. Nov, 2021 | Pubmed ID: 34793591 2D-GolgiTrack-a Semi-automated Tracking System to Quantify Morphological Changes and Dynamics of the Golgi Apparatus and Golgi-derived Membrane Tubules Medical & Biological Engineering & Computing. Nov, 2021 | Pubmed ID: 34783979 Multiparametric Nanoparticle-induced Toxicity Readouts with Single Cell Resolution in HepG2 Multicellular Tumour Spheroids Nanoscale. Oct, 2021 | Pubmed ID: 34661590 A Novel Automated Image Analysis Pipeline for Quantifying Morphological Changes to the Endoplasmic Reticulum in Cultured Human Cells BMC Bioinformatics. Sep, 2021 | Pubmed ID: 34496765 Inactivation Efficacy of Atmospheric Air Plasma and Airborne Acoustic Ultrasound Against Bacterial Biofilms Scientific Reports. 01, 2021 | Pubmed ID: 33504900 A Novel High-content Screening Approach for the Elucidation of C. Jejuni Biofilm Composition and Integrity BMC Microbiology. 01, 2021 | Pubmed ID: 33397288 Emerging Roles for Rho GTPases Operating at the Golgi Complex Small GTPases. Sep-Nov, 2021 | Pubmed ID: 32881632 Antimicrobial Effects of Airborne Acoustic Ultrasound and Plasma Activated Water from Cold and Thermal Plasma Systems on Biofilms Scientific Reports. 10, 2020 | Pubmed ID: 33057158 RNA Interference Screening Identifies Novel Roles for RhoBTB1 and RhoBTB3 in Membrane Trafficking Events in Mammalian Cells Cells. 04, 2020 | Pubmed ID: 32354068 Modification of the Mammalian Endomembrane System in Healthy and Diseased Cells International Journal of Molecular Sciences. Mar, 2020 | Pubmed ID: 32244909 Characterisation of GLUT4 Trafficking in HeLa Cells: Comparable Kinetics and Orthologous Trafficking Mechanisms to 3T3-L1 Adipocytes PeerJ. 2020 | Pubmed ID: 32185116 SCLpred-EMS: Subcellular Localization Prediction of Endomembrane System and Secretory Pathway Proteins by Deep N-to-1 Convolutional Neural Networks Bioinformatics (Oxford, England). 06, 2020 | Pubmed ID: 32142105 Precise Targeting of MiRNA Sites Restores CFTR Activity in CF Bronchial Epithelial Cells Molecular Therapy : the Journal of the American Society of Gene Therapy. 04, 2020 | Pubmed ID: 32059764 Acquisition of Fluoroquinolone Resistance Leads to Increased Biofilm Formation and Pathogenicity in Campylobacter Jejuni Scientific Reports. 12, 2019 | Pubmed ID: 31796849 NeurodegenERation: The Central Role for ER Contacts in Neuronal Function and Axonopathy, Lessons From Hereditary Spastic Paraplegias and Related Diseases Frontiers in Neuroscience. 2019 | Pubmed ID: 31680803 Rab35 Controls Cilium Length, Function and Membrane Composition EMBO Reports. 10, 2019 | Pubmed ID: 31432619 The Challenges and Possibilities of Extracellular Vesicles As Therapeutic Vehicles European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V. Nov, 2019 | Pubmed ID: 31419585 Multitasking Rab Proteins in Autophagy and Membrane Trafficking: A Focus on Rab33b International Journal of Molecular Sciences. Aug, 2019 | Pubmed ID: 31408960 A High-Throughput Automated Confocal Microscopy Platform for Quantitative Phenotyping of Nanoparticle Uptake and Transport in Spheroids Small (Weinheim an Der Bergstrasse, Germany). 09, 2019 | Pubmed ID: 31334922 Computational and Experimental Analysis of Bioactive Peptide Linear Motifs in the Integrin Adhesome PloS One. 2019 | Pubmed ID: 30689642 Rapid Growth Cone Uptake and Dynein-Mediated Axonal Retrograde Transport of Negatively Charged Nanoparticles in Neurons Is Dependent on Size and Cell Type Small (Weinheim an Der Bergstrasse, Germany). 01, 2019 | Pubmed ID: 30565853 Bioinspired Star-Shaped Poly(l-lysine) Polypeptides: Efficient Polymeric Nanocarriers for the Delivery of DNA to Mesenchymal Stem Cells Molecular Pharmaceutics. 05, 2018 | Pubmed ID: 29590755 Heritable Skeletal Disorders Arising from Defects in Processing and Transport of Type I Procollagen from the ER: Perspectives on Possible Therapeutic Approaches Handbook of Experimental Pharmacology. 2018 | Pubmed ID: 29071510 Roles for the VCP Co-factors Npl4 and Ufd1 in Neuronal Function in Drosophila Melanogaster Journal of Genetics and Genomics = Yi Chuan Xue Bao. Oct, 2017 | Pubmed ID: 29037990 Characterization of Carboxylate Nanoparticle Adhesion with the Fungal Pathogen Candida Albicans Nanoscale. Oct, 2017 | Pubmed ID: 29019498 Functional Characterisation of the YIPF Protein Family in Mammalian Cells Histochemistry and Cell Biology. Apr, 2017 | Pubmed ID: 27999994 Systematic Functional Analysis of the Ras GTPase Family Unveils a Conserved Network Required for Anterograde Protein Trafficking Proteomics. 01, 2017 | Pubmed ID: 27957805 Rho GTPases Operating at the Golgi Complex: Implications for Membrane Traffic and Cancer Biology Tissue & Cell. Apr, 2017 | Pubmed ID: 27720426 Genome-Wide SiRNA Screening Using Forward Transfection: Identification of Modulators of Membrane Trafficking in Mammalian Cells Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27581283 A Systematic High-Content Screening Microscopy Approach Reveals Key Roles for Rab33b, OATL1 and Myo6 in Nanoparticle Trafficking in HeLa Cells Scientific Reports. 07, 2016 | Pubmed ID: 27374232 Lysosome Triggered Near-infrared Fluorescence Imaging of Cellular Trafficking Processes in Real Time Nature Communications. Mar, 2016 | Pubmed ID: 26927507 Implementation of the Rank-Weighted Co-localization (RWC) Algorithm in Multiple Image Analysis Platforms for Quantitative Analysis of Microscopy Images Source Code for Biology and Medicine. 2016 | Pubmed ID: 26884809 High-content Analysis of Rab Protein Function at the ER-Golgi Interface Bioarchitecture. 2015 | Pubmed ID: 26693811 A High-content Screening Microscopy Approach to Dissect the Role of Rab Proteins in Golgi-to-ER Retrograde Trafficking Journal of Cell Science. Jul, 2015 | Pubmed ID: 25999475 High-content Analysis for Drug Delivery and Nanoparticle Applications Drug Discovery Today. Aug, 2015 | Pubmed ID: 25908578 A Fluorescent Live Imaging Screening Assay Based on Translocation Criteria Identifies Novel Cytoplasmic Proteins Implicated in G Protein-coupled Receptor Signaling Pathways Molecular & Cellular Proteomics : MCP. May, 2015 | Pubmed ID: 25759509 Hydroxyapatite and Fluorapatite Coatings on Dental Screws: Effects of Blast Coating Process and Biological Response Journal of Materials Science. Materials in Medicine. Jan, 2015 | Pubmed ID: 25578701 Biocompatibility of Ferroelectric Lithium Niobate and the Influence of Polarization Charge on Osteoblast Proliferation and Function Journal of Biomedical Materials Research. Part A. Aug, 2015 | Pubmed ID: 25504748 Trajectory-based Co-localization Measures for Nanoparticle-cell Interaction Studies Small (Weinheim an Der Bergstrasse, Germany). May, 2015 | Pubmed ID: 25504742 The Trials and Tubule-ations of Rab6 Involvement in Golgi-to-ER Retrograde Transport Biochemical Society Transactions. Oct, 2014 | Pubmed ID: 25233431 HGF Induces Epithelial-to-mesenchymal Transition by Modulating the Mammalian Hippo/MST2 and ISG15 Pathways Journal of Proteome Research. Jun, 2014 | Pubmed ID: 24766643 Endoplasmic Reticulum Stress-activated Transcription Factor ATF6α Requires the Disulfide Isomerase PDIA5 to Modulate Chemoresistance Molecular and Cellular Biology. May, 2014 | Pubmed ID: 24636989 RNAi-mediated Inhibition of Apoptosis Fails to Prevent Cationic Nanoparticle-induced Cell Death in Cultured Cells Nanomedicine (London, England). Aug, 2014 | Pubmed ID: 24359549 Actin in Action: Imaging Approaches to Study Cytoskeleton Structure and Function Cells. Nov, 2013 | Pubmed ID: 24709877 High-content Screening and Analysis of the Golgi Complex Methods in Cell Biology. 2013 | Pubmed ID: 24295313 Time Resolved Study of Cell Death Mechanisms Induced by Amine-modified Polystyrene Nanoparticles Nanoscale. Nov, 2013 | Pubmed ID: 24108393 Human Diseases Associated with Form and Function of the Golgi Complex International Journal of Molecular Sciences. Sep, 2013 | Pubmed ID: 24025425 A Real-time Impedance Based Method to Assess Rhodococcus Equi Virulence PloS One. 2013 | Pubmed ID: 23555995 Anti-prion Drug MPPIg5 Inhibits PrP(C) Conversion to PrP(Sc) PloS One. 2013 | Pubmed ID: 23383136 Quantitative Image Analysis Approaches for Probing Rab GTPase Localization and Function in Mammalian Cells Biochemical Society Transactions. Dec, 2012 | Pubmed ID: 23176486 Quantifying Size-dependent Interactions Between Fluorescently Labeled Polystyrene Nanoparticles and Mammalian Cells Journal of Nanobiotechnology. Sep, 2012 | Pubmed ID: 23006133 Chemical Chaperones Improve Protein Secretion and Rescue Mutant Factor VIII in Mice with Hemophilia A PloS One. 2012 | Pubmed ID: 22973456 A Method for Improved Clustering and Classification of Microscopy Images Using Quantitative Co-localization Coefficients BMC Research Notes. Jun, 2012 | Pubmed ID: 22681635 Genome-wide RNAi Screening Identifies Human Proteins with a Regulatory Function in the Early Secretory Pathway Nature Cell Biology. Jun, 2012 | Pubmed ID: 22660414 High-speed Imaging of Rab Family Small GTPases Reveals Rare Events in Nanoparticle Trafficking in Living Cells ACS Nano. Feb, 2012 | Pubmed ID: 22276691 Dual Channel Rank-based Intensity Weighting for Quantitative Co-localization of Microscopy Images BMC Bioinformatics. Oct, 2011 | Pubmed ID: 22017789 Quantitative Proteomics and Dynamic Imaging of the Nucleolus Reveal Distinct Responses to UV and Ionizing Radiation Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21778410 Cationic Nanoparticles Induce Caspase 3-, 7- and 9-mediated Cytotoxicity in a Human Astrocytoma Cell Line Nanotoxicology. Dec, 2011 | Pubmed ID: 21142842 Role of Varp, a Rab21 Exchange Factor and TI-VAMP/VAMP7 Partner, in Neurite Growth EMBO Reports. Oct, 2009 | Pubmed ID: 19745841 Screening the Secretion Machinery: High Throughput Imaging Approaches to Elucidate the Secretory Pathway Seminars in Cell & Developmental Biology. Oct, 2009 | Pubmed ID: 19660568 A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications Alannah S. Chalkley1, Margaritha M. Mysior1, Jeremy C. Simpson1 1Cell Screening Laboratory, UCD School of Biology and Environmental Science, University College Dublin JoVE 63436 Biología
A Robust Method for the Large-Scale Production of Spheroids for High-Content Screening and Analysis Applications Alannah S. Chalkley1, Margaritha M. Mysior1, Jeremy C. Simpson1 1Cell Screening Laboratory, UCD School of Biology and Environmental Science, University College Dublin JoVE 63436 Biología