Joel Gottesfeld

Publications

• A Gene Expression Phenotype in Lymphocytes from Friedreich Ataxia Patients
  Annals of Neurology. Nov, 2011  |   Pubmed ID: 22162061
• Evaluation of Histone Deacetylase Inhibitors As Therapeutics for Neurodegenerative Diseases
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 21913121
• Introduction to the Thematic Minireview Series on Epigenetics
  The Journal of Biological Chemistry. May, 2011  |   Pubmed ID: 21454488
• Prolonged Treatment with Pimelic O-aminobenzamide HDAC Inhibitors Ameliorates the Disease Phenotype of a Friedreich Ataxia Mouse Model
  Neurobiology of Disease. Jun, 2011  |   Pubmed ID: 21397024
• Dynamic Changes in the Copy Number of Pluripotency and Cell Proliferation Genes in Human ESCs and IPSCs During Reprogramming and Time in Culture
  Cell Stem Cell. Jan, 2011  |   Pubmed ID: 21211785
• Friedreich's Ataxia Induced Pluripotent Stem Cells Model Intergenerational GAAâ‹…TTC Triplet Repeat Instability
  Cell Stem Cell. Nov, 2010  |   Pubmed ID: 21040903
• Chemical Biology Meets Biological Chemistry Minireview Series
  The Journal of Biological Chemistry. Apr, 2010  |   Pubmed ID: 20147295
• Two New Pimelic Diphenylamide HDAC Inhibitors Induce Sustained Frataxin Upregulation in Cells from Friedreich's Ataxia Patients and in a Mouse Model
  PloS One. 2010  |   Pubmed ID: 20098685
• Reduced Histone Deacetylase 7 Activity Restores Function to Misfolded CFTR in Cystic Fibrosis
  Nature Chemical Biology. Jan, 2010  |   Pubmed ID: 19966789
• Potent Activity Against K562 Cells by Polyamide-seco-CBI Conjugates Targeting Histone H4 Genes
  Bioorganic & Medicinal Chemistry. Jan, 2010  |   Pubmed ID: 19962902
• Development of Histone Deacetylase Inhibitors As Therapeutics for Neurological Disease
  Future Neurology. Nov, 2009  |   Pubmed ID: 20177429
• Chemical Probes Identify a Role for Histone Deacetylase 3 in Friedreich's Ataxia Gene Silencing
  Chemistry & Biology. Sep, 2009  |   Pubmed ID: 19778726
• Design and Synthesis of Novel Hybrid Benzamide-peptide Histone Deacetylase Inhibitors
  Bioorganic & Medicinal Chemistry Letters. Jul, 2009  |   Pubmed ID: 19362838
• Growth Arrest of BCR-ABL Positive Cells with a Sequence-specific Polyamide-chlorambucil Conjugate
  PloS One. 2008  |   Pubmed ID: 18974832
• Pimelic Diphenylamide 106 is a Slow, Tight-binding Inhibitor of Class I Histone Deacetylases
  The Journal of Biological Chemistry. Dec, 2008  |   Pubmed ID: 18953021
• The HDAC Inhibitor 4b Ameliorates the Disease Phenotype and Transcriptional Abnormalities in Huntington's Disease Transgenic Mice
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008  |   Pubmed ID: 18829438
• Targeting Specific Gene by Alkylating Pyrrole-imidazole Polyamides
  Nucleic Acids Symposium Series (2004). 2008  |   Pubmed ID: 18776404
• HDAC Inhibitors Correct Frataxin Deficiency in a Friedreich Ataxia Mouse Model
  PloS One. 2008  |   Pubmed ID: 18463734
• Small Molecules Targeting Histone H4 As Potential Therapeutics for Chronic Myelogenous Leukemia
  Molecular Cancer Therapeutics. Apr, 2008  |   Pubmed ID: 18413791
• Small Molecules Affecting Transcription in Friedreich Ataxia
  Pharmacology & Therapeutics. Nov, 2007  |   Pubmed ID: 17826840
• Unanticipated Differences Between Alpha- and Gamma-diaminobutyric Acid-linked Hairpin Polyamide-alkylator Conjugates
  Nucleic Acids Research. 2007  |   Pubmed ID: 17170006
• Histone Deacetylase Inhibitors Reverse Gene Silencing in Friedreich's Ataxia
  Nature Chemical Biology. Oct, 2006  |   Pubmed ID: 16921367
• A Two-hit Mechanism for Pre-mitotic Arrest of Cancer Cell Proliferation by a Polyamide-alkylator Conjugate
  Cell Cycle (Georgetown, Tex.). Jul, 2006  |   Pubmed ID: 16861886
• DNA Sequence-specific Polyamides Alleviate Transcription Inhibition Associated with Long GAA.TTC Repeats in Friedreich's Ataxia
  Proceedings of the National Academy of Sciences of the United States of America. Aug, 2006  |   Pubmed ID: 16857735
• Alkylation of Duplex DNA in Nucleosome Core Particles by Duocarmycin SA and Yatakemycin
  Nature Chemical Biology. Feb, 2006  |   Pubmed ID: 16415862
• Induced Fit and "lock and Key" Recognition of 5S RNA by Zinc Fingers of Transcription Factor IIIA
  Journal of Molecular Biology. Mar, 2006  |   Pubmed ID: 16405997
• Inhibition of DNA Binding by Human Estrogen-related Receptor 2 and Estrogen Receptor Alpha with Minor Groove Binding Polyamides
  Biochemistry. Mar, 2005  |   Pubmed ID: 15766247
• Role of DNA Sequence in the Binding Specificity of Synthetic Basic-helix-loop-helix Domains
  Chembiochem : a European Journal of Chemical Biology. Jan, 2005  |   Pubmed ID: 15593070
• Nucleosomes in Solution Exist As a Mixture of Twist-defect States
  Journal of Molecular Biology. Jan, 2005  |   Pubmed ID: 15567414
• Arresting Cancer Proliferation by Small-molecule Gene Regulation
  Chemistry & Biology. Nov, 2004  |   Pubmed ID: 15556009
• Regulation of Gene Expression with Pyrrole-imidazole Polyamides
  Journal of Biotechnology. Aug, 2004  |   Pubmed ID: 15288953
• Molecular Recognition of the Nucleosomal "supergroove"
  Proceedings of the National Academy of Sciences of the United States of America. May, 2004  |   Pubmed ID: 15100411
• Accessibility of Nuclear Chromatin by DNA Binding Polyamides
  Chemistry & Biology. Sep, 2003  |   Pubmed ID: 14522056
• RNA As a Transcriptional Activator
  Chemistry & Biology. Jul, 2003  |   Pubmed ID: 12890529
• Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands
  Journal of Molecular Biology. Feb, 2003  |   Pubmed ID: 12559907
• Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands
  Journal of Molecular Biology. Aug, 2002  |   Pubmed ID: 12144782
• Cyclin L is an RS Domain Protein Involved in Pre-mRNA Splicing
  The Journal of Biological Chemistry. Jul, 2002  |   Pubmed ID: 11980906
• Promoter Scanning for Transcription Inhibition with DNA-binding Polyamides
  Molecular and Cellular Biology. Mar, 2002  |   Pubmed ID: 11865052