Martha Campbell-Thompson Department of Pathology, Immunology and Experimental Medicine University of Florida Biography Publications Institution JoVE Articles Martha Campbell-Thompson has not added a biography. If you are Martha Campbell-Thompson and would like to personalize this page please email our Author Liaison for assistance. Publications Pancreatic Histopathology of Human Monogenic Diabetes Due to Causal Variants in KCNJ11, HNF1A, GATA6, and LMNA The Journal of Clinical Endocrinology and Metabolism. Jan, 2018 | Pubmed ID: 28938416 Response to Comment on Jackson Et Al. Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus. Diabetes Care 2017;40:723-725 Diabetes Care. Oct, 2017 | Pubmed ID: 28931713 Persistence of Pancreatic Insulin MRNA Expression and Proinsulin Protein in Type 1 Diabetes Pancreata Cell Metabolism. Sep, 2017 | Pubmed ID: 28877460 Periodic Acid-Schiff Staining with Diastase Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28752454 Immunohistochemistry Staining for Human Alpha-1 Antitrypsin Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28752453 High Illicit Drug Abuse and Suicide in Organ Donors With Type 1 Diabetes Diabetes Care. Sep, 2017 | Pubmed ID: 28679687 Insulitis in Autoantibody-Positive Pancreatic Donor With History of Gestational Diabetes Mellitus Diabetes Care. 05, 2017 | Pubmed ID: 28428323 5 Year Expression and Neutrophil Defect Repair After Gene Therapy in Alpha-1 Antitrypsin Deficiency Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2017 | Pubmed ID: 28408179 Serum Trypsinogen Levels in Type 1 Diabetes Diabetes Care. 04, 2017 | Pubmed ID: 28115475 Re-addressing the 2013 Consensus Guidelines for the Diagnosis of Insulitis in Human Type 1 Diabetes: is Change Necessary? Diabetologia. Apr, 2017 | Pubmed ID: 28070616 Factors That Influence the Quality of RNA From the Pancreas of Organ Donors Pancreas. Feb, 2017 | Pubmed ID: 27984510 Tissue Distribution and Clonal Diversity of the T and B Cell Repertoire in Type 1 Diabetes JCI Insight. Dec, 2016 | Pubmed ID: 27942583 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Analysis of Self-antigen Specificity of Islet-infiltrating T Cells from Human Donors with Type 1 Diabetes Nature Medicine. Dec, 2016 | Pubmed ID: 27798614 Diagnostic Dilemma: Clinical and Histological Abnormalities in a Hispanic Patient With Diabetes Diabetes Care. 09, 2016 | Pubmed ID: 27555624 Aberrant Menin Expression is an Early Event in Pancreatic Neuroendocrine Tumorigenesis Human Pathology. 10, 2016 | Pubmed ID: 27342911 Presumptive Type 1 Diabetes With Comorbidities and Rapid Progression Despite Numerous Insulin-Positive Islets Diabetes Care. 07, 2016 | Pubmed ID: 27330131 Relative Sensitivity of Immunohistochemistry, Multiple Reaction Monitoring Mass Spectrometry, in Situ Hybridization and PCR to Detect Coxsackievirus B1 in A549 Cells Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Apr, 2016 | Pubmed ID: 26875099 Pancreatic Duct Hyperplasia/dysplasia in Type 1 Diabetes and Pancreatic Weight in Individuals with and Without Diabetes. Reply to Kobayashi T, Aida K, Fukui T Et Al [letter] and Saisho Y [letter] Diabetologia. Apr, 2016 | Pubmed ID: 26861059 Insulitis and β-Cell Mass in the Natural History of Type 1 Diabetes Diabetes. Mar, 2016 | Pubmed ID: 26581594 Beyond the Brain: Disrupted in Schizophrenia 1 Regulates Pancreatic β-cell Function Via Glycogen Synthase Kinase-3β FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2016 | Pubmed ID: 26546129 The Influence of Type 1 Diabetes on Pancreatic Weight Diabetologia. Jan, 2016 | Pubmed ID: 26358584 Abnormalities of the Exocrine Pancreas in Type 1 Diabetes Current Diabetes Reports. Oct, 2015 | Pubmed ID: 26318606 Proteomic Analysis of Disease Stratified Human Pancreas Tissue Indicates Unique Signature of Type 1 Diabetes PloS One. 2015 | Pubmed ID: 26302420 A Combination Hydrogel Microparticle-based Vaccine Prevents Type 1 Diabetes in Non-obese Diabetic Mice Scientific Reports. Aug, 2015 | Pubmed ID: 26279095 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Organ Donor Specimens: What Can They Tell Us About Type 1 Diabetes? Pediatric Diabetes. Aug, 2015 | Pubmed ID: 25998576 New Insight on Human Type 1 Diabetes Biology: NPOD and NPOD-transplantation Current Diabetes Reports. Oct, 2014 | Pubmed ID: 25142715 The Juvenile Diabetes Research Foundation Network for Pancreatic Organ Donors with Diabetes (nPOD) Program: Goals, Operational Model and Emerging Findings Pediatric Diabetes. Feb, 2014 | Pubmed ID: 24325575 Human Treg Responses Allow Sustained Recombinant Adeno-associated Virus-mediated Transgene Expression The Journal of Clinical Investigation. Dec, 2013 | Pubmed ID: 24231351 Response to Comments On: Butler Et Al. Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-producing Neuroendocrine Tumors. Diabetes 2013;62:2595-2604 Diabetes. Oct, 2013 | Pubmed ID: 24065800 Increased Complement Activation in Human Type 1 Diabetes Pancreata Diabetes Care. Nov, 2013 | Pubmed ID: 24041678 Marked Expansion of Exocrine and Endocrine Pancreas with Incretin Therapy in Humans with Increased Exocrine Pancreas Dysplasia and the Potential for Glucagon-producing Neuroendocrine Tumors Diabetes. Jul, 2013 | Pubmed ID: 23524641 Pancreas Organ Weight in Individuals with Disease-associated Autoantibodies at Risk for Type 1 Diabetes JAMA. Dec, 2012 | Pubmed ID: 23232891 Network for Pancreatic Organ Donors with Diabetes (nPOD): Developing a Tissue Biobank for Type 1 Diabetes Diabetes/metabolism Research and Reviews. Oct, 2012 | Pubmed ID: 22585677 Enhanced Expression of Pctk1, Tcf12 and Ccnd1 in Hippocampus of Rats: Impact on Cognitive Function, Synaptic Plasticity and Pathology Neurobiology of Learning and Memory. Jan, 2012 | Pubmed ID: 21982980 Salivary PYY: a Putative Bypass to Satiety PloS One. 2011 | Pubmed ID: 22028819 Selective Stimulation of VEGFR2 Accelerates Progressive Renal Disease The American Journal of Pathology. Jul, 2011 | Pubmed ID: 21640973 Alpha-1 Antitrypsin Protein and Gene Therapies Decrease Autoimmunity and Delay Arthritis Development in Mouse Model Journal of Translational Medicine. 2011 | Pubmed ID: 21345239 Glycogen Storage Disease Type Ia in Canines: a Model for Human Metabolic and Genetic Liver Disease Journal of Biomedicine & Biotechnology. 2011 | Pubmed ID: 21318173 N-glycosylation Augmentation of the Cystic Fibrosis Epithelium Improves Pseudomonas Aeruginosa Clearance American Journal of Respiratory Cell and Molecular Biology. Jun, 2011 | Pubmed ID: 20693405 The Pancreas in Human Type 1 Diabetes Seminars in Immunopathology. Jan, 2011 | Pubmed ID: 20495921 Analysis of Steroid Hormone Effects on Xenografted Human NF1 Tumor Schwann Cells Cancer Biology & Therapy. Oct, 2010 | Pubmed ID: 20699653 Ex Vivo Transduction and Transplantation of Bone Marrow Cells for Liver Gene Delivery of Alpha1-antitrypsin Molecular Therapy : the Journal of the American Society of Gene Therapy. Aug, 2010 | Pubmed ID: 20551917 Diabetic ENOS-knockout Mice Develop Accelerated Retinopathy Investigative Ophthalmology & Visual Science. Oct, 2010 | Pubmed ID: 20435587 Endothelial Von Willebrand Factor Release Due to ENOS Deficiency Predisposes to Thrombotic Microangiopathy in Mouse Aging Kidney The American Journal of Pathology. May, 2010 | Pubmed ID: 20363914 Adeno-associated Virus-mediated Correction of a Canine Model of Glycogen Storage Disease Type Ia Human Gene Therapy. Jul, 2010 | Pubmed ID: 20163245 Gel-mediated Delivery of AAV1 Vectors Corrects Ventilatory Function in Pompe Mice with Established Disease Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2010 | Pubmed ID: 20104213 Soluble Flt-1 Gene Therapy Ameliorates Albuminuria but Accelerates Tubulointerstitial Injury in Diabetic Mice American Journal of Physiology. Renal Physiology. Mar, 2010 | Pubmed ID: 20015944 Combination of Alpha-1 Antitrypsin and Doxycycline Suppresses Collagen-induced Arthritis The Journal of Gene Medicine. Jan, 2010 | Pubmed ID: 19866480 Exendin-4 Treatment of Nonobese Diabetic Mice Increases Beta-cell Proliferation and Fractional Insulin Reactive Area Journal of Diabetes and Its Complications. May-Jun, 2010 | Pubmed ID: 19217320 Immune Depletion with Cellular Mobilization Imparts Immunoregulation and Reverses Autoimmune Diabetes in Nonobese Diabetic Mice Diabetes. Oct, 2009 | Pubmed ID: 19628781 Rabbit Polyclonal Mouse Antithymocyte Globulin Administration Alters Dendritic Cell Profile and Function in NOD Mice to Suppress Diabetogenic Responses Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009 | Pubmed ID: 19342635 Lowering Blood Pressure Blocks Mesangiolysis and Mesangial Nodules, but Not Tubulointerstitial Injury, in Diabetic ENOS Knockout Mice The American Journal of Pathology. Apr, 2009 | Pubmed ID: 19246639 Endothelial Injury Due to ENOS Deficiency Accelerates the Progression of Chronic Renal Disease in the Mouse American Journal of Physiology. Renal Physiology. Feb, 2009 | Pubmed ID: 19036847 Pancreatic Adenocarcinoma Patients with Localised Chronic Severe Pancreatitis Show an Increased Number of Single Beta Cells, Without Alterations in Fractional Insulin Area Diabetologia. Feb, 2009 | Pubmed ID: 19002428 Recombinant AAV Serotype and Capsid Mutant Comparison for Pulmonary Gene Transfer of Alpha-1-antitrypsin Using Invasive and Noninvasive Delivery Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2009 | Pubmed ID: 18941444 Exendin-4 Therapy in NOD Mice with New-onset Diabetes Increases Regulatory T Cell Frequency Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120286 Recombinant Adeno-associated Virus-mediated Gene Delivery of Long Chain Acyl Coenzyme A Dehydrogenase (LCAD) into LCAD-deficient Mice The Journal of Gene Medicine. Oct, 2008 | Pubmed ID: 18720429 The Pivotal Role of VEGF on Glomerular Macrophage Infiltration in Advanced Diabetic Nephropathy Laboratory Investigation; a Journal of Technical Methods and Pathology. Sep, 2008 | Pubmed ID: 18607348 Biochemical Correction of Short-chain Acyl-coenzyme A Dehydrogenase Deficiency After Portal Vein Injection of RAAV8-SCAD Human Gene Therapy. Jun, 2008 | Pubmed ID: 18500942 Murine Antithymocyte Globulin Therapy Alters Disease Progression in NOD Mice by a Time-dependent Induction of Immunoregulation Diabetes. Feb, 2008 | Pubmed ID: 18039815 Partial Correction of the CFTR-dependent ABPA Mouse Model with Recombinant Adeno-associated Virus Gene Transfer of Truncated CFTR Gene The Journal of Gene Medicine. Jan, 2008 | Pubmed ID: 18023072 P53 Regulates FAK Expression in Human Tumor Cells Molecular Carcinogenesis. May, 2008 | Pubmed ID: 17999388 Gene Delivery to Intestinal Epithelial Cells in Vitro and in Vivo with Recombinant Adeno-associated Virus Types 1, 2 and 5 Digestive Diseases and Sciences. May, 2008 | Pubmed ID: 17934813 Distinct Expression and Activity Profiles of Largemouth Bass (Micropterus Salmoides) Estrogen Receptors in Response to Estradiol and Nonylphenol Journal of Molecular Endocrinology. Oct, 2007 | Pubmed ID: 17909263 In Vivo Post-transcriptional Gene Silencing of Alpha-1 Antitrypsin by Adeno-associated Virus Vectors Expressing SiRNA Laboratory Investigation; a Journal of Technical Methods and Pathology. Sep, 2007 | Pubmed ID: 17592477 Ectopic Expression of Wnt10b Decreases Adiposity and Improves Glucose Homeostasis in Obese Rats American Journal of Physiology. Endocrinology and Metabolism. Sep, 2007 | Pubmed ID: 17578883 In Vitro Studies of Steroid Hormones in Neurofibromatosis 1 Tumors and Schwann Cells Molecular Carcinogenesis. Jul, 2007 | Pubmed ID: 17393410 Preclinical Characterization of a Recombinant Adeno-associated Virus Type 1-pseudotyped Vector Demonstrates Dose-dependent Injection Site Inflammation and Dissemination of Vector Genomes to Distant Sites Human Gene Therapy. Mar, 2007 | Pubmed ID: 17376008 Alpha1-antitrypsin Protects Beta-cells from Apoptosis Diabetes. May, 2007 | Pubmed ID: 17360983 Diabetic Endothelial Nitric Oxide Synthase Knockout Mice Develop Advanced Diabetic Nephropathy Journal of the American Society of Nephrology : JASN. Feb, 2007 | Pubmed ID: 17202420 Noninvasive Imaging of Islet Grafts Using Positron-emission Tomography Proceedings of the National Academy of Sciences of the United States of America. Jul, 2006 | Pubmed ID: 16868090 Cystic Fibrosis Transmembrane Conductance Regulator Deficiency Exacerbates Islet Cell Dysfunction After Beta-cell Injury Diabetes. Jul, 2006 | Pubmed ID: 16804061 Alpha1-antitrypsin Gene Therapy Modulates Cellular Immunity and Efficiently Prevents Type 1 Diabetes in Nonobese Diabetic Mice Human Gene Therapy. Jun, 2006 | Pubmed ID: 16776571 Therapeutic Level of Functional Human Alpha 1 Antitrypsin (hAAT) Secreted from Murine Muscle Transduced by Adeno-associated Virus (rAAV1) Vector The Journal of Gene Medicine. Jun, 2006 | Pubmed ID: 16518879 Successful Production of Pseudotyped RAAV Vectors Using a Modified Baculovirus Expression System Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2005 | Pubmed ID: 16213797 Efficient Hepatic Delivery and Expression from a Recombinant Adeno-associated Virus 8 Pseudotyped Alpha1-antitrypsin Vector Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2005 | Pubmed ID: 16085464 Localized Gene Expression Following Administration of Adeno-associated Viral Vectors Via Pancreatic Ducts Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2005 | Pubmed ID: 15979413 Interleukin 10 Attenuates Neointimal Proliferation and Inflammation in Aortic Allografts by a Heme Oxygenase-dependent Pathway Proceedings of the National Academy of Sciences of the United States of America. May, 2005 | Pubmed ID: 15878989 Efficient Transduction of Vascular Endothelial Cells with Recombinant Adeno-associated Virus Serotype 1 and 5 Vectors Human Gene Therapy. Feb, 2005 | Pubmed ID: 15761263 Diabetes Acceleration or Prevention by a Coxsackievirus B4 Infection: Critical Requirements for Both Interleukin-4 and Gamma Interferon Journal of Virology. Jan, 2005 | Pubmed ID: 15613333 Heme Oxygenase-1 Modulates Early Inflammatory Responses: Evidence from the Heme Oxygenase-1-deficient Mouse The American Journal of Pathology. Sep, 2004 | Pubmed ID: 15331427 Sustained Peripheral Expression of Transgene Adiponectin Offsets the Development of Diet-induced Obesity in Rats Proceedings of the National Academy of Sciences of the United States of America. Nov, 2003 | Pubmed ID: 14617771 Systemic Overexpression of IL-10 Induces CD4+CD25+ Cell Populations in Vivo and Ameliorates Type 1 Diabetes in Nonobese Diabetic Mice in a Dose-dependent Fashion Journal of Immunology (Baltimore, Md. : 1950). Sep, 2003 | Pubmed ID: 12928371 Adeno-associated Virus-mediated IL-10 Gene Therapy Inhibits Diabetes Recurrence in Syngeneic Islet Cell Transplantation of NOD Mice Diabetes. Mar, 2003 | Pubmed ID: 12606512 Adeno-associated Virus Transduction of Islets with Interleukin-4 Results in Impaired Metabolic Function in Syngeneic Marginal Islet Mass Transplantation Transplantation. Oct, 2002 | Pubmed ID: 12438968 Intramuscular Administration of Recombinant Adeno-associated Virus 2 Alpha-1 Antitrypsin (rAAV-SERPINA1) Vectors in a Nonhuman Primate Model: Safety and Immunologic Aspects Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2002 | Pubmed ID: 12231168 Benzo(a)pyrene, but Not 2,3,7,8-tetrachlorodibenzo-p-dioxin, Alters Cell Adhesion Proteins in Human Uterine RL95-2 Cells Biochemical and Biophysical Research Communications. May, 2002 | Pubmed ID: 12054747 Adeno-associated Virus Vector-mediated IL-10 Gene Delivery Prevents Type 1 Diabetes in NOD Mice Proceedings of the National Academy of Sciences of the United States of America. Nov, 2001 | Pubmed ID: 11717448 High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network Elizabeth Butterworth1, Wesley Dickerson2, Vindhya Vijay3, Kristina Weitzel1, Julia Cooper1, Eric W. Atkinson4, Jason E. Coleman5, Kevin J. Otto4, Martha Campbell-Thompson1 1Department of Pathology, Immunology and Experimental Medicine, University of Florida, 2Heller School for Social Policy and Management, Brandeis University, 3Department of Medicine, College of Medicine, University of Florida, 4Department of Biomedical Engineering, College of Engineering, University of Florida, 5Department of Pediatrics, College of Medicine, University of Florida JoVE 56859 Bioingeniería
High Resolution 3D Imaging of the Human Pancreas Neuro-insular Network Elizabeth Butterworth1, Wesley Dickerson2, Vindhya Vijay3, Kristina Weitzel1, Julia Cooper1, Eric W. Atkinson4, Jason E. Coleman5, Kevin J. Otto4, Martha Campbell-Thompson1 1Department of Pathology, Immunology and Experimental Medicine, University of Florida, 2Heller School for Social Policy and Management, Brandeis University, 3Department of Medicine, College of Medicine, University of Florida, 4Department of Biomedical Engineering, College of Engineering, University of Florida, 5Department of Pediatrics, College of Medicine, University of Florida JoVE 56859 Bioingeniería