Maureen Gannon Department of Molecular Physiology and Biophysics Vanderbilt University Biography Publications Institution JoVE Articles Maureen Gannon has not added a biography. If you are Maureen Gannon and would like to personalize this page please email our Author Liaison for assistance. Publications The Beta Cell in Type 2 Diabetes Current Diabetes Reports. Aug, 2019 | Pubmed ID: 31399863 Differential Cell Susceptibilities to Kras in the Setting of Obstructive Chronic Pancreatitis Cellular and Molecular Gastroenterology and Hepatology. Jul, 2019 | Pubmed ID: 31310834 Extracellular Matrix-associated Factors Play Critical Roles in Regulating Pancreatic β-cell Proliferation and Survival Endocrinology. Jul, 2019 | Pubmed ID: 31271410 Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis Cellular and Molecular Gastroenterology and Hepatology. Jun, 2019 | Pubmed ID: 31229598 Toll-like Receptors TLR2 and TLR4 Block the Replication of Pancreatic β Cells in Diet-induced Obesity Nature Immunology. Jun, 2019 | Pubmed ID: 31110312 Maternal Western-style Diet Affects Offspring Islet Composition and Function in a Non-human Primate Model of Maternal Over-nutrition Molecular Metabolism. Jul, 2019 | Pubmed ID: 31036449 Sex Modifies Placental Gene Expression in Response to Metabolic and Inflammatory Stress Placenta. Mar, 2019 | Pubmed ID: 30955704 Regulation of the Pancreatic Exocrine Differentiation Program and Morphogenesis by Onecut 1/Hnf6 Cellular and Molecular Gastroenterology and Hepatology. 2019 | Pubmed ID: 30831323 A Call for Improved Reporting of Human Islet Characteristics in Research Articles Diabetes. Feb, 2019 | Pubmed ID: 30552106 A Call for Improved Reporting of Human Islet Characteristics in Research Articles Diabetologia. 02, 2019 | Pubmed ID: 30547229 Increases in Bioactive Lipids Accompany Early Metabolic Changes Associated with β-cell Expansion in Response to Short-term High-fat Diet American Journal of Physiology. Endocrinology and Metabolism. Dec, 2018 | Pubmed ID: 30106624 Sex Differences Underlying Pancreatic Islet Biology and Its Dysfunction Molecular Metabolism. 09, 2018 | Pubmed ID: 29891438 Synaptotagmin 4 Regulates Pancreatic β Cell Maturation by Modulating the Ca Sensitivity of Insulin Secretion Vesicles Developmental Cell. 05, 2018 | Pubmed ID: 29656931 Cooperative Function of Pdx1 and Oc1 in Multipotent Pancreatic Progenitors Impacts Postnatal Islet Maturation and Adaptability American Journal of Physiology. Endocrinology and Metabolism. 04, 2018 | Pubmed ID: 29351489 Gestational Diabetes Exacerbates Maternal Immune Activation Effects in the Developing Brain Molecular Psychiatry. 09, 2018 | Pubmed ID: 28948973 Developmental Programming of the Pancreatic Islet by Overnutrition Trends in Developmental Biology. 2017 | Pubmed ID: 29657386 The Liver Current Biology : CB. Nov, 2017 | Pubmed ID: 29112863 Vascular-derived Connective Tissue Growth Factor (Ctgf) is Critical for Pregnancy-induced β Cell Hyperplasia in Adult Mice Islets. 11, 2017 | Pubmed ID: 29111856 Opposing Effects of Prostaglandin E Receptors EP3 and EP4 on Mouse and Human β-cell Survival and Proliferation Molecular Metabolism. 06, 2017 | Pubmed ID: 28580285 Regulation of Pancreatic β-cell Function and Mass Dynamics by Prostaglandin Signaling Journal of Cell Communication and Signaling. Jun, 2017 | Pubmed ID: 28132118 Onecut Transcription Factors in Development and Disease Trends in Developmental Biology. 2016 | Pubmed ID: 28018056 Growth Hormone Mediates Its Protective Effect in Hepatic Apoptosis Through Hnf6 PloS One. 2016 | Pubmed ID: 27936029 Unexpected Effects of the MIP-CreER Transgene and Tamoxifen on β-cell Growth in C57Bl6/J Male Mice Physiological Reports. Sep, 2016 | Pubmed ID: 27670405 Connective Tissue Growth Factor is Critical for Proper β-cell Function and Pregnancy-induced β-cell Hyperplasia in Adult Mice American Journal of Physiology. Endocrinology and Metabolism. Sep, 2016 | Pubmed ID: 27460898 HNF6 and Rev-erbα Integrate Hepatic Lipid Metabolism by Overlapping and Distinct Transcriptional Mechanisms Genes & Development. 07, 2016 | Pubmed ID: 27445394 Loss of Free Fatty Acid Receptor 2 Leads to Impaired Islet Mass and Beta Cell Survival Scientific Reports. Jun, 2016 | Pubmed ID: 27324831 Threshold-Dependent Cooperativity of Pdx1 and Oc1 in Pancreatic Progenitors Establishes Competency for Endocrine Differentiation and β-Cell Function Cell Reports. 06, 2016 | Pubmed ID: 27292642 Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice Scientific Reports. Feb, 2016 | Pubmed ID: 26887806 Sustained Expression of GLP-1 Receptor Differentially Modulates β-cell Functions in Diabetic and Nondiabetic Mice Biochemical and Biophysical Research Communications. Feb, 2016 | Pubmed ID: 26854076 The PGE2 EP3 Receptor Regulates Diet-Induced Adiposity in Male Mice Endocrinology. Jan, 2016 | Pubmed ID: 26485614 Macrophages Are Essential for CTGF-mediated Adult β-cell Proliferation After Injury Molecular Metabolism. Aug, 2015 | Pubmed ID: 26266091 Activation of FoxM1 Revitalizes the Replicative Potential of Aged β-Cells in Male Mice and Enhances Insulin Secretion Diabetes. Nov, 2015 | Pubmed ID: 26251404 Preserving Mafa Expression in Diabetic Islet β-cells Improves Glycemic Control in Vivo The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25645923 High-fat Diet-induced β-cell Proliferation Occurs Prior to Insulin Resistance in C57Bl/6J Male Mice American Journal of Physiology. Endocrinology and Metabolism. Apr, 2015 | Pubmed ID: 25628421 Connective Tissue Growth Factor Modulates Adult β-cell Maturity and Proliferation to Promote β-cell Regeneration in Mice Diabetes. Apr, 2015 | Pubmed ID: 25392241 Activated FoxM1 Attenuates Streptozotocin-mediated β-cell Death Molecular Endocrinology (Baltimore, Md.). Sep, 2014 | Pubmed ID: 25073103 Loss of HNF6 Expression Correlates with Human Pancreatic Cancer Progression Laboratory Investigation; a Journal of Technical Methods and Pathology. May, 2014 | Pubmed ID: 24638272 Connective Tissue Growth Factor (CTGF/CCN2) Negatively Regulates BMP-2 Induced Osteoblast Differentiation and Signaling Journal of Cellular Physiology. May, 2014 | Pubmed ID: 24127409 An Assay for Small Scale Screening of Candidate β Cell Proliferative Factors Using Intact Islets BioTechniques. Dec, 2013 | Pubmed ID: 24344680 Advancements and Challenges in Generating Accurate Animal Models of Gestational Diabetes Mellitus American Journal of Physiology. Endocrinology and Metabolism. Dec, 2013 | Pubmed ID: 24085033 Onecut1 is Essential for Horizontal Cell Genesis and Retinal Integrity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2013 | Pubmed ID: 23926259 A Physiological Role for Connective Tissue Growth Factor in Early Wound Healing Laboratory Investigation; a Journal of Technical Methods and Pathology. Jan, 2013 | Pubmed ID: 23212098 The Skeletal Site-specific Role of Connective Tissue Growth Factor in Prenatal Osteogenesis Developmental Dynamics : an Official Publication of the American Association of Anatomists. Dec, 2012 | Pubmed ID: 23073844 Inactivation of the Dual Bmp/Wnt Inhibitor Sostdc1 Enhances Pancreatic Islet Function American Journal of Physiology. Endocrinology and Metabolism. Sep, 2012 | Pubmed ID: 22829579 Differential Regulation of Embryonic and Adult β Cell Replication Cell Cycle (Georgetown, Tex.). Jul, 2012 | Pubmed ID: 22659844 Tamoxifen-Induced Cre-loxP Recombination Is Prolonged in Pancreatic Islets of Adult Mice PloS One. 2012 | Pubmed ID: 22470452 Genetic Interactions Between Hepatocyte Nuclear Factor-6 and Notch Signaling Regulate Mouse Intrahepatic Bile Duct Development in Vivo Hepatology (Baltimore, Md.). Jan, 2012 | Pubmed ID: 21898486 Connective Tissue Growth Factor Acts Within Both Endothelial Cells and Beta Cells to Promote Proliferation of Developing Beta Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21876171 Type 2 Diabetes and the Aging Pancreatic Beta Cell Aging. Jun, 2011 | Pubmed ID: 21765202 Diet-induced Impaired Glucose Tolerance and Gestational Diabetes in the Dog Journal of Applied Physiology (Bethesda, Md. : 1985). Feb, 2011 | Pubmed ID: 21088210 Conditional Gene Targeting in Mouse Pancreatic ß-Cells: Analysis of Ectopic Cre Transgene Expression in the Brain Diabetes. Dec, 2010 | Pubmed ID: 20802254 OASIS/CREB3L1 Induces Expression of Genes Involved in Extracellular Matrix Production but Not Classical Endoplasmic Reticulum Stress Response Genes in Pancreatic Beta-cells Endocrinology. Sep, 2010 | Pubmed ID: 20668028 Adult Pancreatic Acinar Cells Give Rise to Ducts but Not Endocrine Cells in Response to Growth Factor Signaling Development (Cambridge, England). Jul, 2010 | Pubmed ID: 20534672 Gestational Diabetes Mellitus Resulting from Impaired Beta-cell Compensation in the Absence of FoxM1, a Novel Downstream Effector of Placental Lactogen Diabetes. Jan, 2010 | Pubmed ID: 19833884 Bioluminescence Imaging in Mouse Models Quantifies Beta Cell Mass in the Pancreas and After Islet Transplantation Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Jan-Feb, 2010 | Pubmed ID: 19548035 Multiple, Temporal-specific Roles for HNF6 in Pancreatic Endocrine and Ductal Differentiation Mechanisms of Development. Dec, 2009 | Pubmed ID: 19766716 Pancreas Cell Fate Birth Defects Research. Part C, Embryo Today : Reviews. Sep, 2009 | Pubmed ID: 19750517 Connective Tissue Growth Factor (CTGF) Inactivation Leads to Defects in Islet Cell Lineage Allocation and Beta-cell Proliferation During Embryogenesis Molecular Endocrinology (Baltimore, Md.). Mar, 2009 | Pubmed ID: 19131512 Regulation of Pancreas Plasticity and Malignant Transformation by Akt Signaling Gastroenterology. Mar, 2009 | Pubmed ID: 19121634 Beta-cell Proliferation, but Not Neogenesis, Following 60% Partial Pancreatectomy is Impaired in the Absence of FoxM1 Diabetes. Nov, 2008 | Pubmed ID: 18728229 Gene Expression Profiling of a Mouse Model of Pancreatic Islet Dysmorphogenesis PloS One. Feb, 2008 | Pubmed ID: 18297134 Pdx-1 Function is Specifically Required in Embryonic Beta Cells to Generate Appropriate Numbers of Endocrine Cell Types and Maintain Glucose Homeostasis Developmental Biology. Feb, 2008 | Pubmed ID: 18155690 Deficiency of Endothelial Nitric-oxide Synthase Confers Susceptibility to Diabetic Nephropathy in Nephropathy-resistant Inbred Mice The American Journal of Pathology. May, 2007 | Pubmed ID: 17456755 Ptf1a Binds to and Activates Area III, a Highly Conserved Region of the Pdx1 Promoter That Mediates Early Pancreas-wide Pdx1 Expression Molecular and Cellular Biology. Jun, 2007 | Pubmed ID: 17403901 BuMP-ing Up Insulin Secretion by Pancreatic Beta Cells Cell Metabolism. Mar, 2007 | Pubmed ID: 17339021 Molecular Regulation of Pancreatic Beta-cell Mass Development, Maintenance, and Expansion Journal of Molecular Endocrinology. Feb, 2007 | Pubmed ID: 17293440 Maintenance of Hepatic Nuclear Factor 6 in Postnatal Islets Impairs Terminal Differentiation and Function of Beta-cells Diabetes. Dec, 2006 | Pubmed ID: 17130469 Pancreatic Islet Production of Vascular Endothelial Growth Factor--a is Essential for Islet Vascularization, Revascularization, and Function Diabetes. Nov, 2006 | Pubmed ID: 17065333 Complementation Rescue of Pdx1 Null Phenotype Demonstrates Distinct Roles of Proximal and Distal Cis-regulatory Sequences in Pancreatic and Duodenal Expression Developmental Biology. Oct, 2006 | Pubmed ID: 16962573 Characterization of Diabetic Nephropathy in a Transgenic Model of Hypoinsulinemic Diabetes American Journal of Physiology. Renal Physiology. Dec, 2006 | Pubmed ID: 16705146 The FoxM1 Transcription Factor is Required to Maintain Pancreatic Beta-cell Mass Molecular Endocrinology (Baltimore, Md.). Aug, 2006 | Pubmed ID: 16556734 Targeted Deletion of a Cis-regulatory Region Reveals Differential Gene Dosage Requirements for Pdx1 in Foregut Organ Differentiation and Pancreas Formation Genes & Development. Jan, 2006 | Pubmed ID: 16418487 Efficient Recombination in Pancreatic Islets by a Tamoxifen-inducible Cre-recombinase Genesis (New York, N.Y. : 2000). Jul, 2005 | Pubmed ID: 15986486 The Proximal Islet-specific Glucose-6-phosphatase Catalytic Subunit-related Protein Autoantigen Promoter is Sufficient to Initiate but Not Maintain Transgene Expression in Mouse Islets in Vivo Diabetes. Jul, 2004 | Pubmed ID: 15220199 Intraislet Endothelial Cells Contribute to Revascularization of Transplanted Pancreatic Islets Diabetes. May, 2004 | Pubmed ID: 15111502 The Role of Pdx1 and HNF6 in Proliferation and Differentiation of Endocrine Precursors Diabetes/metabolism Research and Reviews. Mar-Apr, 2004 | Pubmed ID: 15037986 The Role of the Transcriptional Regulator Ptf1a in Converting Intestinal to Pancreatic Progenitors Nature Genetics. Sep, 2002 | Pubmed ID: 12185368 Conserved Sequences in a Tissue-specific Regulatory Region of the Pdx-1 Gene Mediate Transcription in Pancreatic Beta Cells: Role for Hepatocyte Nuclear Factor 3 Beta and Pax6 Molecular and Cellular Biology. Jul, 2002 | Pubmed ID: 12052878 The PERK Eukaryotic Initiation Factor 2 Alpha Kinase is Required for the Development of the Skeletal System, Postnatal Growth, and the Function and Viability of the Pancreas Molecular and Cellular Biology. Jun, 2002 | Pubmed ID: 11997520 PDX:PBX Complexes Are Required for Normal Proliferation of Pancreatic Cells During Development Proceedings of the National Academy of Sciences of the United States of America. Jan, 2001 | Pubmed ID: 11158595 Analysis of Non-Human Primate Pancreatic Islet Oxygen Consumption Joseph M. Elsakr1, Charles Deeter2, Valerie Ricciardi3, Maureen Gannon1,4,5,6 1Department of Molecular Physiology and Biophysics, Vanderbilt University, 2Agilent Technologies, 3Department of Biological Sciences, Vanderbilt University, 4Department of Veterans Affairs Tennessee Valley, 5Department of Medicine, Vanderbilt University Medical Center, 6Department of Cell and Developmental Biology, Vanderbilt University JoVE 60696 Biología del desarrollo
Analysis of Non-Human Primate Pancreatic Islet Oxygen Consumption Joseph M. Elsakr1, Charles Deeter2, Valerie Ricciardi3, Maureen Gannon1,4,5,6 1Department of Molecular Physiology and Biophysics, Vanderbilt University, 2Agilent Technologies, 3Department of Biological Sciences, Vanderbilt University, 4Department of Veterans Affairs Tennessee Valley, 5Department of Medicine, Vanderbilt University Medical Center, 6Department of Cell and Developmental Biology, Vanderbilt University JoVE 60696 Biología del desarrollo