Nai-Kong V. Cheung Department of Pediatrics Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Nai-Kong V. Cheung has not added a biography. If you are Nai-Kong V. Cheung and would like to personalize this page please email our Author Liaison for assistance. Publications Clonal Evolution During Metastatic Spread in High-risk Neuroblastoma Nature Genetics. May, 2023 | Pubmed ID: 37169874 Identification of Immunotherapy and Radioimmunotherapy Targets on Desmoplastic Small Round Cell Tumors Frontiers in Oncology. 2023 | Pubmed ID: 37091153 Targeting Tumor Vasculature to Improve Antitumor Activity of T Cells Armed Ex Vivo with T Cell Engaging Bispecific Antibody Journal for Immunotherapy of Cancer. Mar, 2023 | Pubmed ID: 36990507 Clinical Outcomes of Pediatric Patients Receiving Multimodality Treatment of Second Central Nervous System Relapse of Neuroblastoma Pediatric Blood & Cancer. Feb, 2023 | Pubmed ID: 36349892 Immunotherapy with Anti-G Monoclonal Antibody in Infants with High-risk Neuroblastoma International Journal of Cancer. Jan, 2023 | Pubmed ID: 35913764 Skeletal Muscle Metastases in Neuroblastoma Share Common Progenitors with Primary Tumor and Biologically Resemble Stage MS Disease Frontiers in Oncology. 2022 | Pubmed ID: 36686814 Desmoplastic Small Round Cell Tumor Cancer Stem Cell-like Cells Resist Chemotherapy but Remain Dependent on the EWSR1-WT1 Oncoprotein Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 36506091 Phase 1 Study of Intraventricular I-omburtamab Targeting B7H3 (CD276)-expressing CNS Malignancies Journal of Hematology & Oncology. Nov, 2022 | Pubmed ID: 36371226 Pretargeting: A Path Forward for Radioimmunotherapy Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Sep, 2022 | Pubmed ID: 36215514 Connecting Telomere Maintenance and Regulation to the Developmental Origin and Differentiation States of Neuroblastoma Tumor Cells Journal of Hematology & Oncology. Aug, 2022 | Pubmed ID: 36030273 Bispecific Antibodies for the Treatment of Neuroblastoma Pharmacology & Therapeutics. Sep, 2022 | Pubmed ID: 35830901 Overcoming Tumor Heterogeneity by Ex Vivo Arming of T Cells Using Multiple Bispecific Antibodies Journal for Immunotherapy of Cancer. Jan, 2022 | Pubmed ID: 35086947 Bone Marrow Surveillance of Pediatric Cancer Survivors Identifies Clones That Predict Therapy-Related Leukemia Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2022 | Pubmed ID: 35078859 Intraperitoneal Pretargeted Radioimmunotherapy for Colorectal Peritoneal Carcinomatosis Molecular Cancer Therapeutics. Jan, 2022 | Pubmed ID: 34667111 KMT2A-MAML2 Rearrangement Emerged and Regressed During Neuroblastoma Therapy Without Leukemia After 12.8-year Follow-up Pediatric Blood & Cancer. Jan, 2022 | Pubmed ID: 34550633 Influence of Fc Modifications and IgG Subclass on Biodistribution of Humanized Antibodies Targeting L1CAM Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Apr, 2022 | Pubmed ID: 34353869 Ganglioside GD2 Enhances the Malignant Phenotypes of Melanoma Cells by Cooperating with Integrins International Journal of Molecular Sciences. Dec, 2021 | Pubmed ID: 35008849 Phase I Trial of Oral Yeast-Derived β-Glucan to Enhance Anti-GD2 Immunotherapy of Resistant High-Risk Neuroblastoma Cancers. Dec, 2021 | Pubmed ID: 34944886 Immunotherapy and Radioimmunotherapy for Desmoplastic Small Round Cell Tumor Frontiers in Oncology. 2021 | Pubmed ID: 34869013 Reciprocal Impacts of Telomerase Activity and ADRN/MES Differentiation State in Neuroblastoma Tumor Biology Communications Biology. Nov, 2021 | Pubmed ID: 34799676 Human Cytomegalovirus Infection Promotes Expansion of a Functionally Superior Cytoplasmic CD3 NK Cell Subset with a Bcl11b-Regulated T Cell Signature Journal of Immunology (Baltimore, Md. : 1950). Nov, 2021 | Pubmed ID: 34625521 Novel Potent Anti-STEAP1 Bispecific Antibody to Redirect T Cells for Cancer Immunotherapy Journal for Immunotherapy of Cancer. Sep, 2021 | Pubmed ID: 34497115 Modulating Tumor Infiltrating Myeloid Cells to Enhance Bispecific Antibody-driven T Cell Infiltration and Anti-tumor Response Journal of Hematology & Oncology. Sep, 2021 | Pubmed ID: 34496935 T Cell Engaging Bispecific Antibodies Targeting CD33 IgV and IgC Domains for the Treatment of Acute Myeloid Leukemia Journal for Immunotherapy of Cancer. May, 2021 | Pubmed ID: 34035113 Potent Ex Vivo Armed T Cells Using Recombinant Bispecific Antibodies for Adoptive Immunotherapy with Reduced Cytokine Release Journal for Immunotherapy of Cancer. May, 2021 | Pubmed ID: 33986124 Potent Antitumor Effect of T Cells Armed with Anti-GD2 Bispecific Antibody Pediatric Blood & Cancer. Jul, 2021 | Pubmed ID: 33844437 Engineered Cells As a Test Platform for Radiohaptens in Pretargeted Imaging and Radioimmunotherapy Applications Bioconjugate Chemistry. Apr, 2021 | Pubmed ID: 33819023 A Novel Multimeric IL15/IL15Rα-Fc Complex to Enhance Cancer Immunotherapy Oncoimmunology. Mar, 2021 | Pubmed ID: 33763293 Survival Impact of Anti-GD2 Antibody Response in a Phase II Ganglioside Vaccine Trial Among Patients With High-Risk Neuroblastoma With Prior Disease Progression Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2021 | Pubmed ID: 33326254 IntraOmmaya Compartmental Radioimmunotherapy Using I-omburtamab-pharmacokinetic Modeling to Optimize Therapeutic Index European Journal of Nuclear Medicine and Molecular Imaging. Apr, 2021 | Pubmed ID: 33047248 A Self-Assembling and Disassembling (SADA) Bispecific Antibody (BsAb) Platform for Curative Two-step Pretargeted Radioimmunotherapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2021 | Pubmed ID: 32958698 Editorial: Bispecific Antibodies for T-Cell Based Immunotherapy Frontiers in Oncology. 2020 | Pubmed ID: 33363043 GD2 or HER2 Targeting T Cell Engaging Bispecific Antibodies to Treat Osteosarcoma Journal of Hematology & Oncology. Dec, 2020 | Pubmed ID: 33303017 Overcoming Leukemia Heterogeneity by Combining T Cell Engaging Bispecific Antibodies Journal for Immunotherapy of Cancer. Nov, 2020 | Pubmed ID: 33239418 B7H3-Directed Intraperitoneal Radioimmunotherapy With Radioiodinated Omburtamab for Desmoplastic Small Round Cell Tumor and Other Peritoneal Tumors: Results of a Phase I Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2020 | Pubmed ID: 33119478 Cancer Immunotherapy Via Targeted TGF-β Signalling Blockade in T Cells Nature. Nov, 2020 | Pubmed ID: 33087933 Pan-neuroblastoma Analysis Reveals Age- and Signature-associated Driver Alterations Nature Communications. Oct, 2020 | Pubmed ID: 33056981 Alpha Radioimmunotherapy Using Ac-proteus-DOTA for Solid Tumors - Safety at Curative Doses Theranostics. 2020 | Pubmed ID: 33052220 Reduced-dose Craniospinal Irradiation for Central Nervous System Relapsed Neuroblastoma Pediatric Blood & Cancer. Sep, 2020 | Pubmed ID: 32608559 Targets and Antibody Formats for Immunotherapy of Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2020 | Pubmed ID: 32167865 Interdomain Spacing and Spatial Configuration Drive the Potency of IgG-[L]-scFv T Cell Bispecific Antibodies Science Translational Medicine. Mar, 2020 | Pubmed ID: 32161106 Immunotherapy of Pediatric Solid Tumors: Treatments at a Crossroads, with an Emphasis on Antibodies Cancer Immunology Research. Feb, 2020 | Pubmed ID: 32015013 An -Acetylgalactosamino Dendron-Clearing Agent for High-Therapeutic-Index DOTA-Hapten Pretargeted Radioimmunotherapy Bioconjugate Chemistry. Mar, 2020 | Pubmed ID: 31891487 ATRX In-Frame Fusion Neuroblastoma Is Sensitive to EZH2 Inhibition Via Modulation of Neuronal Gene Signatures Cancer Cell. Nov, 2019 | Pubmed ID: 31631027 Silencing Fc Domains in T Cell-Engaging Bispecific Antibodies Improves T-cell Trafficking and Antitumor Potency Cancer Immunology Research. Dec, 2019 | Pubmed ID: 31615814 Biodistribution and Dosimetry of Intraventricularly Administered I-Omburtamab in Patients with Metastatic Leptomeningeal Tumors Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Dec, 2019 | Pubmed ID: 31405921 Exploiting Signaling Pathways and Immune Targets Beyond the Standard of Care for Ewing Sarcoma Frontiers in Oncology. 2019 | Pubmed ID: 31275859 Telomere Trimming and DNA Damage As Signatures of High Risk Neuroblastoma Neoplasia (New York, N.Y.). Jul, 2019 | Pubmed ID: 31128432 Targeted Radioimmunotherapy for Embryonal Tumor with Multilayered Rosettes Journal of Neuro-oncology. May, 2019 | Pubmed ID: 30879172 Reduced-Dose Radiation Therapy to the Primary Site is Effective for High-Risk Neuroblastoma: Results From a Prospective Trial International Journal of Radiation Oncology, Biology, Physics. Jun, 2019 | Pubmed ID: 30763661 Theranostic Pretargeted Radioimmunotherapy of Internalizing Solid Tumor Antigens in Human Tumor Xenografts in Mice: Curative Treatment of HER2-positive Breast Carcinoma Theranostics. 2018 | Pubmed ID: 30429889 Adoptive Immunotherapy with Haploidentical Natural Killer Cells and Anti-GD2 Monoclonal Antibody M3F8 for Resistant Neuroblastoma: Results of a Phase I Study Oncoimmunology. 2018 | Pubmed ID: 30221057 Development of a Tetravalent Anti-GPA33/Anti-CD3 Bispecific Antibody for Colorectal Cancers Molecular Cancer Therapeutics. Oct, 2018 | Pubmed ID: 30082472 Convection-enhanced Delivery for Diffuse Intrinsic Pontine Glioma: a Single-centre, Dose-escalation, Phase 1 Trial The Lancet. Oncology. Aug, 2018 | Pubmed ID: 29914796 A Potent Tetravalent T-cell-engaging Bispecific Antibody Against CD33 in Acute Myeloid Leukemia Blood Advances. Jun, 2018 | Pubmed ID: 29858209 Treatment and Outcome of Adult-onset Neuroblastoma International Journal of Cancer. Sep, 2018 | Pubmed ID: 29574715 Dose-escalation is Needed for Gross Disease in High-risk Neuroblastoma Pediatric Blood & Cancer. Jul, 2018 | Pubmed ID: 29469198 TCR-mimic Bispecific Antibodies Targeting LMP2A Show Potent Activity Against EBV Malignancies JCI Insight. Feb, 2018 | Pubmed ID: 29467338 Radiation Therapy to Sites of Metastatic Disease As Part of Consolidation in High-Risk Neuroblastoma: Can Long-term Control Be Achieved? International Journal of Radiation Oncology, Biology, Physics. Apr, 2018 | Pubmed ID: 29439882 Genotyping Natural Killer Immune Checkpoints to Discover Biomarkers of Response Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2018 | Pubmed ID: 29122934 Targeting Intracellular Antigens with PMHC-Binding Antibodies: A Phage Display Approach Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29116509 A Phase II Study of Radioimmunotherapy with Intraventricular I-3F8 for Medulloblastoma Pediatric Blood & Cancer. Jan, 2018 | Pubmed ID: 28940863 T Cell Engaging Bispecific Antibody (T-BsAb): From Technology to Therapeutics Pharmacology & Therapeutics. Feb, 2018 | Pubmed ID: 28834699 -amplified Stage 2/3 Neuroblastoma: Excellent Survival in the Era of Anti-G Immunotherapy Oncotarget. Nov, 2017 | Pubmed ID: 29221128 Phase I Trial of Anti-GD2 Monoclonal Antibody Hu3F8 Plus GM-CSF: Impact of Body Weight, Immunogenicity and Anti-GD2 Response on Pharmacokinetics and Survival Oncoimmunology. 2017 | Pubmed ID: 29147617 Erratum to 'Limitations and Opportunities for Immune Checkpoint Inhibitors in Pediatric Malignancies' [Cancer Treat. Rev. 58C (2017) 22-33] Cancer Treatment Reviews. Nov, 2017 | Pubmed ID: 29033261 Curative Multicycle Radioimmunotherapy Monitored by Quantitative SPECT/CT-Based Theranostics, Using Bispecific Antibody Pretargeting Strategy in Colorectal Cancer Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Nov, 2017 | Pubmed ID: 28705917 Bispecific Antibody Does Not Induce T-cell Death Mediated by Chimeric Antigen Receptor Against Disialoganglioside GD2 Oncoimmunology. 2017 | Pubmed ID: 28680755 Limitations and Opportunities for Immune Checkpoint Inhibitors in Pediatric Malignancies Cancer Treatment Reviews. Jul, 2017 | Pubmed ID: 28622628 A Phase I Study of Single-agent Perifosine for Recurrent or Refractory Pediatric CNS and Solid Tumors PloS One. 2017 | Pubmed ID: 28582410 Immunotherapy of Hepatocellular Carcinoma Using Chimeric Antigen Receptors and Bispecific Antibodies Cancer Letters. Jul, 2017 | Pubmed ID: 28428075 Targeted Drug Distribution in Tumor Extracellular Fluid of GD2-expressing Neuroblastoma Patient-derived Xenografts Using SN-38-loaded Nanoparticles Conjugated to the Monoclonal Antibody 3F8 Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2017 | Pubmed ID: 28412222 Overcoming Resistance to HER2-targeted Therapy with a Novel HER2/CD3 Bispecific Antibody Oncoimmunology. 2017 | Pubmed ID: 28405494 Combination of Bevacizumab, Irinotecan, and Temozolomide for Refractory or Relapsed Neuroblastoma: Results of a Phase II Study Pediatric Blood & Cancer. Aug, 2017 | Pubmed ID: 28111925 A Phase I/Ib Trial Targeting the Pi3k/Akt Pathway Using Perifosine: Long-term Progression-free Survival of Patients with Resistant Neuroblastoma International Journal of Cancer. Jan, 2017 | Pubmed ID: 27649927 Temporal Stability and Molecular Persistence of the Bone Marrow Plasma Cell Antibody Repertoire Nature Communications. Dec, 2016 | Pubmed ID: 28000661 Local Control With 21-Gy Radiation Therapy for High-Risk Neuroblastoma International Journal of Radiation Oncology, Biology, Physics. Oct, 2016 | Pubmed ID: 27473818 Successful Engineering of a Highly Potent Single-chain Variable-fragment (scFv) Bispecific Antibody to Target Disialoganglioside (GD2) Positive Tumors Oncoimmunology. Jun, 2016 | Pubmed ID: 27471647 Oncotargets GD2 and GD3 Are Highly Expressed in Sarcomas of Children, Adolescents, and Young Adults Pediatric Blood & Cancer. Oct, 2016 | Pubmed ID: 27304202 Antitumor Efficacy of Anti-GD2 IgG1 Is Enhanced by Fc Glyco-Engineering Cancer Immunology Research. Jul, 2016 | Pubmed ID: 27197064 KIR3DL1 Allelic Polymorphism and HLA-B Epitopes Modulate Response to Anti-GD2 Monoclonal Antibody in Patients With Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jul, 2016 | Pubmed ID: 27069083 Arsenic Trioxide As a Radiation Sensitizer for 131I-Metaiodobenzylguanidine Therapy: Results of a Phase II Study Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Feb, 2016 | Pubmed ID: 26742708 Lack of Survival Advantage with Autologous Stem-cell Transplantation in High-risk Neuroblastoma Consolidated by Anti-GD2 Immunotherapy and Isotretinoin Oncotarget. Jan, 2016 | Pubmed ID: 26623730 Theranostic Pretargeted Radioimmunotherapy of Colorectal Cancer Xenografts in Mice Using Picomolar Affinity ⁸⁶Y- or ¹⁷⁷Lu-DOTA-Bn Binding ScFv C825/GPA33 IgG Bispecific Immunoconjugates European Journal of Nuclear Medicine and Molecular Imaging. May, 2016 | Pubmed ID: 26596724 Humanized Affinity-matured Monoclonal Antibody 8H9 Has Potent Antitumor Activity and Binds to FG Loop of Tumor Antigen B7-H3 The Journal of Biological Chemistry. Dec, 2015 | Pubmed ID: 26487718 Generation of TCR-Like Antibodies Using Phage Display Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 26424273 Anti-proliferative and Pro-apoptotic Activity of GD2 Ganglioside-specific Monoclonal Antibody 3F8 in Human Melanoma Cells Oncoimmunology. Aug, 2015 | Pubmed ID: 26405581 A Distinct Gene Expression Signature Characterizes Human Neuroblastoma Cancer Stem Cells Stem Cell Research. Sep, 2015 | Pubmed ID: 26342562 Immunotherapy of Childhood Sarcomas Frontiers in Oncology. 2015 | Pubmed ID: 26301204 Prolonged Progression-free Survival After Consolidating Second or Later Remissions of Neuroblastoma with Anti-G Immunotherapy and Isotretinoin: a Prospective Phase II Study Oncoimmunology. Jul, 2015 | Pubmed ID: 26140243 Human Derived Dimerization Tag Enhances Tumor Killing Potency of a T-cell Engaging Bispecific Antibody Oncoimmunology. Apr, 2015 | Pubmed ID: 26137406 Radioimmunotherapy of Human Tumours Nature Reviews. Cancer. Jun, 2015 | Pubmed ID: 25998714 Low Incidence of Radionecrosis in Children Treated with Conventional Radiation Therapy and Intrathecal Radioimmunotherapy Journal of Neuro-oncology. Jun, 2015 | Pubmed ID: 25944385 A Dual-specific Anti-IGF-1/IGF-2 Human Monoclonal Antibody Alone and in Combination with Temsirolimus for Therapy of Neuroblastoma International Journal of Cancer. Nov, 2015 | Pubmed ID: 25924852 Alteration of Electrostatic Surface Potential Enhances Affinity and Tumor Killing Properties of Anti-ganglioside GD2 Monoclonal Antibody Hu3F8 The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25851904 Chimeric Antigen Receptors and Bispecific Antibodies to Retarget T Cells in Pediatric Oncology Pediatric Blood & Cancer. Aug, 2015 | Pubmed ID: 25832831 Osteochondroma in Long-term Survivors of High-risk Neuroblastoma Cancer. Jun, 2015 | Pubmed ID: 25728463 Disialoganglioside GD2 As a Therapeutic Target for Human Diseases Expert Opinion on Therapeutic Targets. Mar, 2015 | Pubmed ID: 25604432 Bone Marrow Minimal Residual Disease Was an Early Response Marker and a Consistent Independent Predictor of Survival After Anti-GD2 Immunotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2015 | Pubmed ID: 25559819 Retargeting T Cells to GD2 Pentasaccharide on Human Tumors Using Bispecific Humanized Antibody Cancer Immunology Research. Mar, 2015 | Pubmed ID: 25542634 Antibody Induced Pain in Children: An Opportunity to Study Pain Mechanism, IgG Design and Analgesics Pediatric Blood & Cancer. Feb, 2015 | Pubmed ID: 25382406 Structural Design of Disialoganglioside GD2 and CD3-bispecific Antibodies to Redirect T Cells for Tumor Therapy International Journal of Cancer. Jan, 2015 | Pubmed ID: 24895182 GD2-targeted Immunotherapy and Radioimmunotherapy Seminars in Oncology. Oct, 2014 | Pubmed ID: 25440605 When Overall Survival Fails to Confirm Event-free Survival, Should the Latter Be Used to Set the Standard of Care? Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2014 | Pubmed ID: 25403224 Structure Based Refinement of a Humanized Monoclonal Antibody That Targets Tumor Antigen Disialoganglioside GD2 Frontiers in Immunology. 2014 | Pubmed ID: 25177320 Deep MicroRNA Sequencing Reveals Downregulation of MiR-29a in Neuroblastoma Central Nervous System Metastasis Genes, Chromosomes & Cancer. Oct, 2014 | Pubmed ID: 24898736 Striking Dichotomy in Outcome of MYCN-amplified Neuroblastoma in the Contemporary Era Cancer. Jul, 2014 | Pubmed ID: 24691684 Key Role for Myeloid Cells: Phase II Results of Anti-G(D2) Antibody 3F8 Plus Granulocyte-macrophage Colony-stimulating Factor for Chemoresistant Osteomedullary Neuroblastoma International Journal of Cancer. Nov, 2014 | Pubmed ID: 24644014 Imaging the Norepinephrine Transporter in Neuroblastoma: a Comparison of [18F]-MFBG and 123I-MIBG Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2014 | Pubmed ID: 24573553 Phase I Trial of a Bivalent Gangliosides Vaccine in Combination with β-glucan for High-risk Neuroblastoma in Second or Later Remission Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2014 | Pubmed ID: 24520094 Engineering Anti-GD2 Monoclonal Antibodies for Cancer Immunotherapy FEBS Letters. Jan, 2014 | Pubmed ID: 24295643 Recurrent Pre-existing and Acquired DNA Copy Number Alterations, Including Focal TERT Gains, in Neuroblastoma Central Nervous System Metastases Genes, Chromosomes & Cancer. Dec, 2013 | Pubmed ID: 24123354 Anti-GD2 Antibody 3F8 and Barley-derived (1 → 3),(1 → 4)-β-D-glucan: A Phase I Study in Patients with Chemoresistant Neuroblastoma Oncoimmunology. Mar, 2013 | Pubmed ID: 23802080 Neuroblastoma: Developmental Biology, Cancer Genomics and Immunotherapy Nature Reviews. Cancer. Jun, 2013 | Pubmed ID: 23702928 In Silico Driven Redesign of a Clinically Relevant Antibody for the Treatment of GD2 Positive Tumors PloS One. 2013 | Pubmed ID: 23696816 Posterior Reversible Encephalopathy Syndrome in Neuroblastoma Patients Receiving Anti-GD2 3F8 Monoclonal Antibody Cancer. Aug, 2013 | Pubmed ID: 23633099 Early Negative Minimal Residual Disease in Bone Marrow After Immunotherapy is Less Predictive of Late or Non-marrow Relapse Among Patients with High-risk Stage 4 Neuroblastoma Pediatric Blood & Cancer. Jul, 2013 | Pubmed ID: 23335404 Ifosfamide, Carboplatin, and Etoposide for Neuroblastoma: a High-dose Salvage Regimen and Review of the Literature Cancer. Feb, 2013 | Pubmed ID: 22951749 Murine Anti-GD2 Monoclonal Antibody 3F8 Combined with Granulocyte-macrophage Colony-stimulating Factor and 13-cis-retinoic Acid in High-risk Patients with Stage 4 Neuroblastoma in First Remission Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2012 | Pubmed ID: 22869886 Unlicensed NK Cells Target Neuroblastoma Following Anti-GD2 Antibody Treatment The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22863621 Humanizing Murine IgG3 Anti-GD2 Antibody M3F8 Substantially Improves Antibody-dependent Cell-mediated Cytotoxicity While Retaining Targeting in Vivo Oncoimmunology. Jul, 2012 | Pubmed ID: 22754766 Anti-CD3 × anti-GD2 Bispecific Antibody Redirects T-cell Cytolytic Activity to Neuroblastoma Targets Pediatric Blood & Cancer. Dec, 2012 | Pubmed ID: 22707078 Association of Age at Diagnosis and Genetic Mutations in Patients with Neuroblastoma JAMA. Mar, 2012 | Pubmed ID: 22416102 Activation of Peripheral-blood Granulocytes is Strongly Correlated with Patient Outcome After Immunotherapy with Anti-GD2 Monoclonal Antibody and Granulocyte-macrophage Colony-stimulating Factor Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2012 | Pubmed ID: 22203761 Plerixafor Plus Granulocyte-colony Stimulating Factor for Autologous Hematopoietic Stem Cell Mobilization in Patients with Metastatic Neuroblastoma Pediatric Blood & Cancer. Mar, 2012 | Pubmed ID: 21416584 MYCN and MYC Regulate Tumor Proliferation and Tumorigenesis Directly Through BMI1 in Human Neuroblastomas FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2011 | Pubmed ID: 21856782 Successful Multifold Dose Escalation of Anti-GD2 Monoclonal Antibody 3F8 in Patients with Neuroblastoma: a Phase I Study Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2011 | Pubmed ID: 21343563 Resectability and Operative Morbidity After Chemotherapy in Neuroblastoma Patients with Encasement of Major Visceral Arteries Journal of Pediatric Surgery. Jan, 2011 | Pubmed ID: 21238649 Checkpoint Kinase Inhibitor Synergizes with DNA-damaging Agents in G1 Checkpoint-defective Neuroblastoma International Journal of Cancer. Oct, 2011 | Pubmed ID: 21154747 High-dose Carboplatin-irinotecan-temozolomide: Treatment Option for Neuroblastoma Resistant to Topotecan Pediatric Blood & Cancer. Mar, 2011 | Pubmed ID: 21049517 Two-compartment Model of Radioimmunotherapy Delivered Through Cerebrospinal Fluid European Journal of Nuclear Medicine and Molecular Imaging. Feb, 2011 | Pubmed ID: 20936407 High-dose Cyclophosphamide-irinotecan-vincristine for Primary Refractory Neuroblastoma European Journal of Cancer (Oxford, England : 1990). Jan, 2011 | Pubmed ID: 20934323 Preliminary Results of a Phase I Trial of Prophylactic Ethanol-lock Administration to Prevent Mediport Catheter-related Bloodstream Infections Journal of Pediatric Surgery. Oct, 2010 | Pubmed ID: 20920713 Differential Impact of High-dose Cyclophosphamide, Topotecan, and Vincristine in Clinical Subsets of Patients with Chemoresistant Neuroblastoma Cancer. Jun, 2010 | Pubmed ID: 20564411 Neuroblastoma: Therapeutic Strategies for a Clinical Enigma Cancer Treatment Reviews. Jun, 2010 | Pubmed ID: 20227189 Whole Neuraxis Irradiation to Address Central Nervous System Relapse in High-risk Neuroblastoma International Journal of Radiation Oncology, Biology, Physics. Nov, 2010 | Pubmed ID: 20207502 High Frequency of P53/MDM2/p14ARF Pathway Abnormalities in Relapsed Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2010 | Pubmed ID: 20145180 Compartmental Intrathecal Radioimmunotherapy: Results for Treatment for Metastatic CNS Neuroblastoma Journal of Neuro-oncology. May, 2010 | Pubmed ID: 19890606 Analysis of GD2/GM2 Synthase MRNA As a Biomarker for Small Cell Lung Cancer Lung Cancer (Amsterdam, Netherlands). Feb, 2010 | Pubmed ID: 19457569 KIR and HLA Genotypes Are Associated with Disease Progression and Survival Following Autologous Hematopoietic Stem Cell Transplantation for High-risk Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009 | Pubmed ID: 19934297 Reducing Epitope Spread During Affinity Maturation of an Anti-ganglioside GD2 Antibody Journal of Immunology (Baltimore, Md. : 1950). Nov, 2009 | Pubmed ID: 19812201 A Focal Lesion in the Falx Cerebri: Harbinger of Classic Stage 4 Neuroblastoma in an Infant Cured Despite Residual Disease After Minimal Therapy Pediatric Blood & Cancer. Dec, 2009 | Pubmed ID: 19711437 MicroRNA MiR-29 Modulates Expression of Immunoinhibitory Molecule B7-H3: Potential Implications for Immune Based Therapy of Human Solid Tumors Cancer Research. Aug, 2009 | Pubmed ID: 19584290 Hyperfractionated Low-dose (21 Gy) Radiotherapy for Cranial Skeletal Metastases in Patients with High-risk Neuroblastoma International Journal of Radiation Oncology, Biology, Physics. Nov, 2009 | Pubmed ID: 19427746 Monoclonal Antibody Therapies for Solid Tumors Expert Opinion on Biological Therapy. Mar, 2009 | Pubmed ID: 19216623 Specific Gene Expression Profiles and Chromosomal Abnormalities Are Associated with Infant Disseminated Neuroblastoma BMC Cancer. Feb, 2009 | Pubmed ID: 19192278 Sensitivity of Surveillance Studies for Detecting Asymptomatic and Unsuspected Relapse of High-risk Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2009 | Pubmed ID: 19171710 Reduced Risk of Secondary Leukemia with Fewer Cycles of Dose-intensive Induction Chemotherapy in Patients with Neuroblastoma Pediatric Blood & Cancer. Jul, 2009 | Pubmed ID: 19148951 Methionine Depletion with Recombinant Methioninase: in Vitro and in Vivo Efficacy Against Neuroblastoma and Its Synergism with Chemotherapeutic Drugs International Journal of Cancer. Apr, 2009 | Pubmed ID: 19089915 Management and Outcome of Stage 3 Neuroblastoma European Journal of Cancer (Oxford, England : 1990). Jan, 2009 | Pubmed ID: 18996003 Exploiting Gene Expression Profiling to Identify Novel Minimal Residual Disease Markers of Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2008 | Pubmed ID: 18980998 Solitary Relapse of Desmoplastic Small Round Cell Tumor Detected by Positron Emission Tomography/computed Tomography Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2008 | Pubmed ID: 18809603 Recurrent Metastatic Neuroblastoma Followed by Myelodysplastic Syndrome: Possible Leukemogenic Role of Temozolomide Pediatric Blood & Cancer. Oct, 2008 | Pubmed ID: 18570300 Prospective Tracing of MLL-FRYL Clone with Low MEIS1 Expression from Emergence During Neuroblastoma Treatment to Diagnosis of Myelodysplastic Syndrome Blood. Apr, 2008 | Pubmed ID: 18195096 Transient Sialoadenitis: a Complication of 131I-metaiodobenzylguanidine Therapy Pediatric Blood & Cancer. Jun, 2008 | Pubmed ID: 17973318 Brain-sparing Radiotherapy for Neuroblastoma Skull Metastases Pediatric Blood & Cancer. Jun, 2008 | Pubmed ID: 17973314 Distinct FAK-Src Activation Events Promote Alpha5beta1 and Alpha4beta1 Integrin-stimulated Neuroblastoma Cell Motility Oncogene. Feb, 2008 | Pubmed ID: 17828307 Novel Markers of Subclinical Disease for Ewing Family Tumors from Gene Expression Profiling Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007 | Pubmed ID: 18056173 Phase I Study of Targeted Radioimmunotherapy for Leptomeningeal Cancers Using Intra-Ommaya 131-I-3F8 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2007 | Pubmed ID: 18048828 Induction for High-risk Neuroblastoma Pediatric Blood & Cancer. Sep, 2007 | Pubmed ID: 17417798 Cyclin D1, a Novel Molecular Marker of Minimal Residual Disease, in Metastatic Neuroblastoma The Journal of Molecular Diagnostics : JMD. Apr, 2007 | Pubmed ID: 17384216 Disialoganglioside Directed Immunotherapy of Neuroblastoma Cancer Investigation. Feb, 2007 | Pubmed ID: 17364560 High-dose Cyclophosphamide Inhibition of Humoral Immune Response to Murine Monoclonal Antibody 3F8 in Neuroblastoma Patients: Broad Implications for Immunotherapy Pediatric Blood & Cancer. Apr, 2007 | Pubmed ID: 16421906 Irinotecan Plus Temozolomide for Relapsed or Refractory Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2006 | Pubmed ID: 17114661 Ototoxicity from High-dose Use of Platinum Compounds in Patients with Neuroblastoma Cancer. Jul, 2006 | Pubmed ID: 16779793 What Factors Predict a Favorable Outcome in Young Children with Disseminated Neuroblastoma? Nature Clinical Practice. Oncology. May, 2006 | Pubmed ID: 16683000 FCGR2A Polymorphism is Correlated with Clinical Outcome After Immunotherapy of Neuroblastoma with Anti-GD2 Antibody and Granulocyte Macrophage Colony-stimulating Factor Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2006 | Pubmed ID: 16682723 Exploiting the MIBG-avidity of Neuroblastoma for Staging and Treatment Pediatric Blood & Cancer. Dec, 2006 | Pubmed ID: 16544298 Sialyltransferase STX (ST8SiaII): a Novel Molecular Marker of Metastatic Neuroblastoma International Journal of Cancer. Jul, 2006 | Pubmed ID: 16450393 Liver Involvement in Neuroblastoma: the Memorial Sloan-Kettering Experience Supports Treatment Reduction in Young Patients Pediatric Blood & Cancer. Mar, 2006 | Pubmed ID: 16124002 Neuroblastoma--from Genetic Profiles to Clinical Challenge The New England Journal of Medicine. Nov, 2005 | Pubmed ID: 16306518 Radioimmunotargeting of Human Rhabdomyosarcoma Using Monoclonal Antibody 8H9 Cancer Biotherapy & Radiopharmaceuticals. Oct, 2005 | Pubmed ID: 16248769 Prognostic Value of MYCN and ID2 Overexpression in Neuroblastoma Pediatric Blood & Cancer. Dec, 2005 | Pubmed ID: 16047351 Rituximab Therapy of Lymphoma is Enhanced by Orally Administered (1-->3),(1-->4)-D-beta-glucan Leukemia Research. Jun, 2005 | Pubmed ID: 15863209 Long-term Complications in Survivors of Advanced Stage Neuroblastoma Pediatric Blood & Cancer. Sep, 2005 | Pubmed ID: 15714447 Antibody-based Targeted Radiation to Pediatric Tumors Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2005 | Pubmed ID: 15653664 Five-day Courses of Irinotecan As Palliative Therapy for Patients with Neuroblastoma Cancer. Feb, 2005 | Pubmed ID: 15637685 Characteristics of Stem Cells from Human Neuroblastoma Cell Lines and in Tumors Neoplasia (New York, N.Y.). 2004 | Pubmed ID: 15720811 Reduction from Seven to Five Cycles of Intensive Induction Chemotherapy in Children with High-risk Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2004 | Pubmed ID: 15611504 Treatment of Neuroblastoma Meningeal Carcinomatosis with Intrathecal Application of Alpha-emitting Atomic Nanogenerators Targeting Disialo-ganglioside GD2 Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2004 | Pubmed ID: 15501978 Measuring Circulating Neuroblastoma Cells by Quantitative Reverse Transcriptase-polymerase Chain Reaction Analysis Cancer. Nov, 2004 | Pubmed ID: 15484213 Treatment Reduction for Neuroblastoma Pediatric Blood & Cancer. Nov, 2004 | Pubmed ID: 15390354 Single-chain Fv-streptavidin Substantially Improved Therapeutic Index in Multistep Targeting Directed at Disialoganglioside GD2 Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2004 | Pubmed ID: 15136638 The Impact of Gross Total Resection on Local Control and Survival in High-risk Neuroblastoma Journal of Pediatric Surgery. Mar, 2004 | Pubmed ID: 15017562 Pharmacokinetics, Dosimetry, and Toxicity of the Targetable Atomic Generator, 225Ac-HuM195, in Nonhuman Primates Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2004 | Pubmed ID: 14734685 Camptothecin Analogs (irinotecan or Topotecan) Plus High-dose Cyclophosphamide As Preparative Regimens for Antibody-based Immunotherapy in Resistant Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2004 | Pubmed ID: 14734455 Radically Different Treatment Recommendations for Newly Diagnosed Neuroblastoma: Pitfalls in Assessment of Risk Journal of Pediatric Hematology/oncology. Jan, 2004 | Pubmed ID: 14707711 Treatment of Spinal Involvement in Neuroblastoma Patients Pediatric Neurosurgery. Dec, 2003 | Pubmed ID: 14734862 Neuroblastoma in Adolescents and Adults: the Memorial Sloan-Kettering Experience Medical and Pediatric Oncology. Dec, 2003 | Pubmed ID: 14595707 Early Molecular Response of Marrow Disease to Biologic Therapy is Highly Prognostic in Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2003 | Pubmed ID: 14551304 Anti-idiotypic Antibody Facilitates ScFv Chimeric Immune Receptor Gene Transduction and Clonal Expansion of Human Lymphocytes for Tumor Therapy Hybridoma and Hybridomics. Aug, 2003 | Pubmed ID: 14511566 Genome-wide Analysis of Gene Expression Associated with MYCN in Human Neuroblastoma Cancer Research. Aug, 2003 | Pubmed ID: 12907629 Oral Topotecan for Refractory and Relapsed Neuroblastoma: a Retrospective Analysis Journal of Pediatric Hematology/oncology. Aug, 2003 | Pubmed ID: 12902911 Curability of Recurrent Disseminated Disease After Surgery Alone for Local-regional Neuroblastoma Using Intensive Chemotherapy and Anti-G(D2) Immunotherapy Journal of Pediatric Hematology/oncology. Jul, 2003 | Pubmed ID: 12847316 Tumor Lysis Syndrome, Neuroblastoma, and Correlation Between Serum Lactate Dehydrogenase Levels and MYCN-amplification Medical and Pediatric Oncology. Jul, 2003 | Pubmed ID: 12764755 Quantitation of GD2 Synthase MRNA by Real-time Reverse Transcriptase Polymerase Chain Reaction: Clinical Utility in Evaluating Adjuvant Therapy in Neuroblastoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2003 | Pubmed ID: 12637475 Impact of Metaiodobenzylguanidine Scintigraphy on Assessing Response of High-risk Neuroblastoma to Dose-intensive Induction Chemotherapy Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2003 | Pubmed ID: 12637474 Anti-idiotypic Antibody As the Surrogate Antigen for Cloning ScFv and Its Fusion Proteins Hybridoma and Hybridomics. Dec, 2002 | Pubmed ID: 12573107 Orally Administered Beta-glucans Enhance Anti-tumor Effects of Monoclonal Antibodies Cancer Immunology, Immunotherapy : CII. Nov, 2002 | Pubmed ID: 12384807 Disialoganglioside GD2 and a Novel Tumor Antigen: Potential Targets for Immunotherapy of Desmoplastic Small Round Cell Tumor Medical and Pediatric Oncology. Dec, 2002 | Pubmed ID: 12376975 Chronic Neuroblastoma Cancer. Sep, 2002 | Pubmed ID: 12216106 Evolving Significance of Prognostic Markers Associated with Treatment Improvement in Patients with Stage 4 Neuroblastoma Cancer. May, 2002 | Pubmed ID: 12173347 Quantitation of GD2 Synthase MRNA by Real-time Reverse Transcription-polymerase Chain Reaction: Utility in Bone Marrow Purging of Neuroblastoma by Anti-GD2 Antibody 3F8 Cancer. Jun, 2002 | Pubmed ID: 12115395 Oral (1-->3),(1-->4)-beta-D-glucan Synergizes with Antiganglioside GD2 Monoclonal Antibody 3F8 in the Therapy of Neuroblastoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2002 | Pubmed ID: 12006541 Panhandle and Reverse-panhandle PCR Enable Cloning of Der(11) and Der(other) Genomic Breakpoint Junctions of MLL Translocations and Identify Complex Translocation of MLL, AF-4, and CDK6 Proceedings of the National Academy of Sciences of the United States of America. Apr, 2002 | Pubmed ID: 11930009 Novel Regions of Allelic Imbalance Identified by Genome-wide Analysis of Neuroblastoma Cancer Research. Mar, 2002 | Pubmed ID: 11912152 Clinical Categories of Neuroblastoma Are Associated with Different Patterns of Loss of Heterozygosity on Chromosome Arm 1p The Journal of Molecular Diagnostics : JMD. Feb, 2000 | Pubmed ID: 11272900 Implications of EPHB6, EFNB2, and EFNB3 Expressions in Human Neuroblastoma Proceedings of the National Academy of Sciences of the United States of America. Sep, 2000 | Pubmed ID: 10984508 Detection of Leukemia-associated MLL-GAS7 Translocation Early During Chemotherapy with DNA Topoisomerase II Inhibitors Proceedings of the National Academy of Sciences of the United States of America. Mar, 2000 | Pubmed ID: 10706619 Surface Antigen Expression and Complement Susceptibility of Differentiated Neuroblastoma Clones The American Journal of Pathology. Mar, 2000 | Pubmed ID: 10702424 Association of CYP3A4 Genotype with Treatment-related Leukemia Proceedings of the National Academy of Sciences of the United States of America. Oct, 1998 | Pubmed ID: 9789061 Antigen-dependent CD28 Signaling Selectively Enhances Survival and Proliferation in Genetically Modified Activated Human Primary T Lymphocytes The Journal of Experimental Medicine. Aug, 1998 | Pubmed ID: 9705944 تتبع الاتجار بالخلايا التائية المستحثة بالأجسام المضادة ثنائية النوع باستخدام الخلايا التائية البشرية المستحثة باللوسيفيراز Madelyn Espinosa-Cotton1, Hong-Fen Guo1, Nai-Kong V. Cheung1 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center JoVE 64390 Investigación sobre el cáncer
تتبع الاتجار بالخلايا التائية المستحثة بالأجسام المضادة ثنائية النوع باستخدام الخلايا التائية البشرية المستحثة باللوسيفيراز Madelyn Espinosa-Cotton1, Hong-Fen Guo1, Nai-Kong V. Cheung1 1Department of Pediatrics, Memorial Sloan Kettering Cancer Center JoVE 64390 Investigación sobre el cáncer