Pieter S. Hiemstra PulmoScience Laboratory, Department of Pulmonology Leiden University Medical Center Biography Publications Institution JoVE Articles Pieter S. Hiemstra has not added a biography. If you are Pieter S. Hiemstra and would like to personalize this page please email our Author Liaison for assistance. Publications Smoking Increases Expression of the SARS-CoV-2 Spike Protein-binding Long ACE2 Isoform in Bronchial Epithelium Respiratory Research. May, 2023 | Pubmed ID: 37170105 Multi-ancestry Genome-wide Association Analyses Improve Resolution of Genes and Pathways Influencing Lung Function and Chronic Obstructive Pulmonary Disease Risk Nature Genetics. Mar, 2023 | Pubmed ID: 36914875 Th2 High and Mast Cell Gene Signatures Are Associated with Corticosteroid Sensitivity in COPD Thorax. Apr, 2023 | Pubmed ID: 36598042 Combination of IL-17A/F and TNF-α Uniquely Alters the Bronchial Epithelial Cell Proteome to Enhance Proteins That Augment Neutrophil Migration Journal of Inflammation (London, England). Dec, 2022 | Pubmed ID: 36517803 SARS-CoV-2-specific CD4 and CD8 T Cell Responses Can Originate from Cross-reactive CMV-specific T Cells ELife. Nov, 2022 | Pubmed ID: 36408799 Cigarette Smoke Impairs Airway Epithelial Wound Repair: Role of Modulation of Epithelial-Mesenchymal Transition Processes and Notch-1 Signaling Antioxidants (Basel, Switzerland). Oct, 2022 | Pubmed ID: 36290742 The Lower Airways Microbiota and Antimicrobial Peptides Indicate Dysbiosis in Sarcoidosis Microbiome. Oct, 2022 | Pubmed ID: 36258251 Early Transcriptional Responses of Bronchial Epithelial Cells to Whole Cigarette Smoke Mirror Those of In-vivo Exposed Human Bronchial Mucosa Respiratory Research. Sep, 2022 | Pubmed ID: 36056356 Keratin 8 is a Scaffolding and Regulatory Protein of ERAD Complexes Cellular and Molecular Life Sciences : CMLS. Sep, 2022 | Pubmed ID: 36045259 Association of Bronchial Steroid Inducible Methylation Quantitative Trait Loci with Asthma and Chronic Obstructive Pulmonary Disease Treatment Response Clinical and Translational Allergy. Aug, 2022 | Pubmed ID: 36036237 Host Succinate Inhibits Influenza Virus Infection Through Succinylation and Nuclear Retention of the Viral Nucleoprotein The EMBO Journal. Jun, 2022 | Pubmed ID: 35506364 3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes ACS Biomaterials Science & Engineering. Jun, 2022 | Pubmed ID: 35502997 Vitamin D Supplementation in Chronic Obstructive Pulmonary Disease Patients with Low Serum Vitamin D: a Randomized Controlled Trial The American Journal of Clinical Nutrition. Aug, 2022 | Pubmed ID: 35383823 High MiR203a-3p and MiR-375 Expression in the Airways of Smokers with and Without COPD Scientific Reports. Apr, 2022 | Pubmed ID: 35379844 Dysregulated Mitochondrial Metabolism Upon Cigarette Smoke Exposure in Various Human Bronchial Epithelial Cell Models Disease Models & Mechanisms. Mar, 2022 | Pubmed ID: 35344036 Performance of Five Metagenomic Classifiers for Virus Pathogen Detection Using Respiratory Samples from a Clinical Cohort Pathogens (Basel, Switzerland). Mar, 2022 | Pubmed ID: 35335664 Role of Air Pollutants in Airway Epithelial Barrier Dysfunction in Asthma and COPD European Respiratory Review : an Official Journal of the European Respiratory Society. Mar, 2022 | Pubmed ID: 35321933 Organoid-based Expansion of Patient-derived Primary Alveolar Type 2 Cells for Establishment of Alveolus Epithelial Lung-Chip Cultures American Journal of Physiology. Lung Cellular and Molecular Physiology. Apr, 2022 | Pubmed ID: 35137633 Lung Epithelial Cells Interact with Immune Cells and Bacteria to Shape the Microenvironment in Tuberculosis Thorax. Apr, 2022 | Pubmed ID: 35017314 The Lower Airways Microbiome and Antimicrobial Peptides in Idiopathic Pulmonary Fibrosis Differ from Chronic Obstructive Pulmonary Disease PloS One. 2022 | Pubmed ID: 34990493 Prolonged Activation of Nasal Immune Cell Populations and Development of Tissue-resident SARS-CoV-2-specific CD8 T Cell Responses Following COVID-19 Nature Immunology. Jan, 2022 | Pubmed ID: 34937933 Determinants of Expression of SARS-CoV-2 Entry-related Genes in Upper and Lower Airways Allergy. Feb, 2022 | Pubmed ID: 34698405 Novel Insights into Surfactant Protein C Trafficking Revealed Through the Study of a Pathogenic Mutant The European Respiratory Journal. Jan, 2022 | Pubmed ID: 34049951 Bronchial Gene Expression Signature Associated with Rate of Subsequent FEV Decline in Individuals with and at Risk of COPD Thorax. Jan, 2022 | Pubmed ID: 33972452 Personalized Pollen Monitoring and Symptom Scores: A Feasibility Study in Grass Pollen Allergic Patients Frontiers in Allergy. 2021 | Pubmed ID: 35387060 Kallikrein-related Peptidase 5 Contributes to the Remodeling and Repair of Bronchial Epithelium FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Oct, 2021 | Pubmed ID: 34582061 Factors Associated with Physical Activity Among COPD Patients with Mild or Moderate Airflow Obstruction Monaldi Archives for Chest Disease = Archivio Monaldi Per Le Malattie Del Torace. Sep, 2021 | Pubmed ID: 34523325 Disease Modeling Following Organoid-based Expansion of Airway Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2021 | Pubmed ID: 34378410 The Course of AαVal541 As a Proteinase 3 Specific Neo-Epitope After Alpha-1-Antitrypsin Augmentation in Severe Deficient Patients International Journal of Molecular Sciences. Jul, 2021 | Pubmed ID: 34360796 Comparison of Genome-wide Gene Expression Profiling by RNA Sequencing Microarray in Bronchial Biopsies of COPD Patients Before and After Inhaled Corticosteroid Treatment: Does It Provide New Insights? ERJ Open Research. Apr, 2021 | Pubmed ID: 34164552 Repairing Damaged Lungs Using Regenerative Therapy Current Opinion in Pharmacology. Aug, 2021 | Pubmed ID: 34161852 Gender Specific Airway Gene Expression in COPD Sub-phenotypes Supports a Role of Mitochondria and of Different Types of Leukocytes Scientific Reports. Jun, 2021 | Pubmed ID: 34145303 RAGE and TLR4 Differentially Regulate Airway Hyperresponsiveness: Implications for COPD Allergy. Apr, 2021 | Pubmed ID: 32799375 A New Portable Sampler to Monitor Pollen at Street Level in the Environment of Patients The Science of the Total Environment. Nov, 2020 | Pubmed ID: 32887011 An Emerging Class of Air Pollutants: Potential Effects of Microplastics to Respiratory Human Health? The Science of the Total Environment. Dec, 2020 | Pubmed ID: 32827829 Impact of the Local Inflammatory Environment on Mucosal Vitamin D Metabolism and Signaling in Chronic Inflammatory Lung Diseases Frontiers in Immunology. 2020 | Pubmed ID: 32754156 Tiotropium and Fluticasone Inhibit Rhinovirus-Induced Mucin Production Via Multiple Mechanisms in Differentiated Airway Epithelial Cells Frontiers in Cellular and Infection Microbiology. 2020 | Pubmed ID: 32637364 Wnt/β-catenin Signaling is Critical for Regenerative Potential of Distal Lung Epithelial Progenitor Cells in Homeostasis and Emphysema Stem Cells (Dayton, Ohio). Nov, 2020 | Pubmed ID: 32526076 Suramin Inhibits SARS-CoV-2 Infection in Cell Culture by Interfering with Early Steps of the Replication Cycle Antimicrobial Agents and Chemotherapy. Jul, 2020 | Pubmed ID: 32513797 Host-microbe Cross-talk in the Lung Microenvironment: Implications for Understanding and Treating Chronic Lung Disease The European Respiratory Journal. Aug, 2020 | Pubmed ID: 32430415 Vitamin D Deficiency in Asthma and Chronic Obstructive Pulmonary Disease. A Chicken-or-Egg Story American Journal of Respiratory and Critical Care Medicine. Aug, 2020 | Pubmed ID: 32352312 Adiposity is a Confounding Factor Which Largely Explains the Association of Serum Vitamin D Concentrations with C-reactive Protein, Leptin and Adiponectin Cytokine. Jul, 2020 | Pubmed ID: 32325367 Short-term and Long-term Effect of a High-intensity Pulmonary Rehabilitation Programme in Obese Patients with Asthma: a Randomised Controlled Trial The European Respiratory Journal. Jul, 2020 | Pubmed ID: 32299852 Modulation of Airway Epithelial Innate Immunity and Wound Repair by M(GM-CSF) and M(M-CSF) Macrophages Journal of Innate Immunity. 2020 | Pubmed ID: 32289801 In Vitro Modelling of Alveolar Repair at the Air-liquid Interface Using Alveolar Epithelial Cells Derived from Human Induced Pluripotent Stem Cells Scientific Reports. Mar, 2020 | Pubmed ID: 32218519 ERS International Congress, Madrid, 2019: Highlights from the Basic and Translational Science Assembly ERJ Open Research. Jan, 2020 | Pubmed ID: 32154289 Tumor Mutational Load, CD8 T Cells, Expression of PD-L1 and HLA Class I to Guide Immunotherapy Decisions in NSCLC Patients Cancer Immunology, Immunotherapy : CII. May, 2020 | Pubmed ID: 32047958 Author Correction: Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells Scientific Reports. Jan, 2020 | Pubmed ID: 31937899 Innate Immunity of the Lung Journal of Innate Immunity. 2020 | Pubmed ID: 31801141 Mitochondria: at the Crossroads of Regulating Lung Epithelial Cell Function in Chronic Obstructive Pulmonary Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2020 | Pubmed ID: 31693390 Blood Eosinophil Count and Airway Epithelial Transcriptome Relationships in COPD Versus Asthma Allergy. Feb, 2020 | Pubmed ID: 31506971 TGF-β1 Impairs Vitamin D-Induced and Constitutive Airway Epithelial Host Defense Mechanisms Journal of Innate Immunity. 2020 | Pubmed ID: 30970352 Osteopontin Expression in Small Airway Epithelium in Copd is Dependent on Differentiation and Confined to Subsets of Cells Scientific Reports. Oct, 2019 | Pubmed ID: 31664154 The Respiratory Virome and Exacerbations in Patients with Chronic Obstructive Pulmonary Disease PloS One. 2019 | Pubmed ID: 31647831 Translation of Findings to Patients with Asthma: a Timely and Compelling Challenge The European Respiratory Journal. Oct, 2019 | Pubmed ID: 31601723 Perioperative ProADM-change is Associated with the Development of Acute Respiratory Distress Syndrome in Critically Ill Cardiac Surgery Patients: a Prospective Cohort Study Biomarkers in Medicine. Sep, 2019 | Pubmed ID: 31544475 Sputum Microbiota and Inflammation at Stable State and During Exacerbations in a Cohort of Chronic Obstructive Pulmonary Disease (COPD) Patients PloS One. 2019 | Pubmed ID: 31527888 Airway and Alveolar Epithelial Cells in Culture The European Respiratory Journal. Nov, 2019 | Pubmed ID: 31515398 Extract of Helicobacter Pylori Ameliorates Parameters of Airway Inflammation and Goblet Cell Hyperplasia Following Repeated Allergen Exposure International Archives of Allergy and Immunology. 2019 | Pubmed ID: 31242493 From the Pathophysiology of the Human Lung Alveolus to Epigenetic Editing: Congress 2018 Highlights from ERS Assembly 3 "Basic and Translational Science." ERJ Open Research. Apr, 2019 | Pubmed ID: 31111040 Macrophage Function in Chronic Obstructive Pulmonary Disease: The Many Faces of Notch Signalling EBioMedicine. May, 2019 | Pubmed ID: 31047859 Antimicrobial Host Defence Peptides: Immunomodulatory Functions and Translational Prospects Advances in Experimental Medicine and Biology. 2019 | Pubmed ID: 30980358 TGF-β Activation Impairs Fibroblast Ability to Support Adult Lung Epithelial Progenitor Cell Organoid Formation American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2019 | Pubmed ID: 30969812 Effect of Long-term Corticosteroid Treatment on MicroRNA and Gene-expression Profiles in COPD The European Respiratory Journal. Apr, 2019 | Pubmed ID: 30846474 Dynamic Differences in Dietary Polyunsaturated Fatty Acid Metabolism in Sputum of COPD Patients and Controls Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Mar, 2019 | Pubmed ID: 30528790 Electronic Cigarettes: a Task Force Report from the European Respiratory Society The European Respiratory Journal. Feb, 2019 | Pubmed ID: 30464018 Stem Cell-based Lung-on-Chips: The Best of Both Worlds? Advanced Drug Delivery Reviews. Feb, 2019 | Pubmed ID: 30009883 Air-Liquid Interface Models for Respiratory Toxicology Research: Consensus Workshop and Recommendations Applied in Vitro Toxicology. Jun, 2018 | Pubmed ID: 32953944 How to Write a Response to the Reviewers of Your Manuscript Breathe (Sheffield, England). Dec, 2018 | Pubmed ID: 30519299 Retinoic Acid Signaling Balances Adult Distal Lung Epithelial Progenitor Cell Growth and Differentiation EBioMedicine. Oct, 2018 | Pubmed ID: 30236449 Contribution of Host Defence Proteins and Peptides to Host-Microbiota Interactions in Chronic Inflammatory Lung Diseases Vaccines. Jul, 2018 | Pubmed ID: 30060554 Immunomodulatory Innate Defence Regulator (IDR) Peptide Alleviates Airway Inflammation and Hyper-responsiveness Thorax. Oct, 2018 | Pubmed ID: 29853649 Aerobic Exercise Protects from Pseudomonas Aeruginosa-Induced Pneumonia in Elderly Mice Journal of Innate Immunity. 2018 | Pubmed ID: 29843140 A Novel Method for Expansion and Differentiation of Mouse Tracheal Epithelial Cells in Culture Scientific Reports. May, 2018 | Pubmed ID: 29743551 Basic and Translational Research in the The European Respiratory Journal. May, 2018 | Pubmed ID: 29724787 Predictive Value of Eosinophils and Neutrophils on Clinical Effects of ICS in COPD Respirology (Carlton, Vic.). Nov, 2018 | Pubmed ID: 29696728 Airway Epithelial Cell Function and Respiratory Host Defense in Chronic Obstructive Pulmonary Disease Chinese Medical Journal. May, 2018 | Pubmed ID: 29692382 Response to Comment on "Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease" Journal of Immunology (Baltimore, Md. : 1950). May, 2018 | Pubmed ID: 29685947 Mesenchymal Stromal Cells: a Novel Therapy for the Treatment of Chronic Obstructive Pulmonary Disease? Thorax. Jun, 2018 | Pubmed ID: 29653970 Aberrant Epithelial Differentiation by Cigarette Smoke Dysregulates Respiratory Host Defence The European Respiratory Journal. Apr, 2018 | Pubmed ID: 29545277 Effects of E-Cigarette Use on Human Lung Tissue. On Harm Reduction and Causing Harm American Journal of Respiratory and Critical Care Medicine. Jul, 2018 | Pubmed ID: 29518342 Assembly 3: Basic and Translational Sciences Breathe (Sheffield, England). Mar, 2018 | Pubmed ID: 29515672 Farm Dust Reduces Viral Load in Human Bronchial Epithelial Cells by Increasing Barrier Function and Antiviral Responses The Journal of Allergy and Clinical Immunology. May, 2018 | Pubmed ID: 29425849 Effect of Diesel Exhaust Generated by a City Bus Engine on Stress Responses and Innate Immunity in Primary Bronchial Epithelial Cell Cultures Toxicology in Vitro : an International Journal Published in Association with BIBRA. Apr, 2018 | Pubmed ID: 29408669 Therapeutic Application of an Extract of Ameliorates the Development of Allergic Airway Disease Journal of Immunology (Baltimore, Md. : 1950). Mar, 2018 | Pubmed ID: 29352004 Associations of Serum 25(OH)D Concentrations with Lung Function, Airway Inflammation and Common Cold in the General Population Nutrients. Jan, 2018 | Pubmed ID: 29301349 Human Lung Epithelial Cell Cultures for Analysis of Inhaled Toxicants: Lessons Learned and Future Directions Toxicology in Vitro : an International Journal Published in Association with BIBRA. Mar, 2018 | Pubmed ID: 29155131 Airway Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease: Role of Cigarette Smoke Exposure American Journal of Respiratory Cell and Molecular Biology. Feb, 2018 | Pubmed ID: 28933915 Pulmonary Function, Exhaled Nitric Oxide and Symptoms in Asthma Patients with Obesity: a Cross-sectional Study Respiratory Research. Dec, 2017 | Pubmed ID: 29212496 Reprogramming of Cellular Metabolism: Driver for Airway Remodelling in COPD? The European Respiratory Journal. Nov, 2017 | Pubmed ID: 29191957 MicroRNA Profiling in Lung Tissue and Bronchoalveolar Lavage of Cigarette Smoke-exposed Mice and in COPD Patients: a Translational Approach Scientific Reports. Oct, 2017 | Pubmed ID: 28993685 Acute and Chronic Effects of Treatment with Mesenchymal Stromal Cells on LPS-induced Pulmonary Inflammation, Emphysema and Atherosclerosis Development PloS One. 2017 | Pubmed ID: 28910300 Pre-surgical Pulmonary Rehabilitation in Asthma Patients Undergoing Bariatric Surgery Obesity Surgery. Nov, 2017 | Pubmed ID: 28831733 The Effects of Selective Hematopoietic Expression of Human IL-37 on Systemic Inflammation and Atherosclerosis in LDLr-Deficient Mice International Journal of Molecular Sciences. Aug, 2017 | Pubmed ID: 28792474 Bone Morphogenetic Protein 9 Protects Against Neonatal Hyperoxia-Induced Impairment of Alveolarization and Pulmonary Inflammation Frontiers in Physiology. 2017 | Pubmed ID: 28751863 Cigarette Smoke Differentially Affects IL-13-induced Gene Expression in Human Airway Epithelial Cells Physiological Reports. Jul, 2017 | Pubmed ID: 28701525 The Effect of Tiotropium in Combination with Olodaterol on House Dust Mite-induced Allergic Airway Disease Pulmonary Pharmacology & Therapeutics. Aug, 2017 | Pubmed ID: 28687462 Airway Inflammation in COPD After Long-term Withdrawal of Inhaled Corticosteroids The European Respiratory Journal. Jun, 2017 | Pubmed ID: 28619964 Use of Airway Epithelial Cell Culture to Unravel the Pathogenesis and Study Treatment in Obstructive Airway Diseases Pulmonary Pharmacology & Therapeutics. Aug, 2017 | Pubmed ID: 28502841 Defining Asthma-COPD Overlap Syndrome: a Population-based Study The European Respiratory Journal. May, 2017 | Pubmed ID: 28461292 Antimicrobial Peptide Levels Are Linked to Airway Inflammation, Bacterial Colonisation and Exacerbations in Chronic Obstructive Pulmonary Disease The European Respiratory Journal. Mar, 2017 | Pubmed ID: 28298400 Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells American Journal of Respiratory Cell and Molecular Biology. Jun, 2017 | Pubmed ID: 28231019 Antibacterial Defense of Human Airway Epithelial Cells from Chronic Obstructive Pulmonary Disease Patients Induced by Acute Exposure to Nontypeable Haemophilus Influenzae: Modulation by Cigarette Smoke Journal of Innate Immunity. 2017 | Pubmed ID: 28171878 Diesel Exhaust Alters the Response of Cultured Primary Bronchial Epithelial Cells from Patients with Chronic Obstructive Pulmonary Disease (COPD) to Non-typeable Haemophilus Influenzae Respiratory Research. Jan, 2017 | Pubmed ID: 28129777 Airway Inflammation in COPD After Long-term Withdrawal of Inhaled Corticosteroids The European Respiratory Journal. Jan, 2017 | Pubmed ID: 28049170 Xenobiotic Metabolism in Differentiated Human Bronchial Epithelial Cells Archives of Toxicology. May, 2017 | Pubmed ID: 27738743 Standard Radiotherapy but Not Chemotherapy Impairs Systemic Immunity in Non-small Cell Lung Cancer Oncoimmunology. 2016 | Pubmed ID: 28123900 Cigarette Smoke Modulates Repair and Innate Immunity Following Injury to Airway Epithelial Cells PloS One. 2016 | Pubmed ID: 27829065 Functional Characterisation of Bone Marrow-derived Mesenchymal Stromal Cells from COPD Patients ERJ Open Research. Apr, 2016 | Pubmed ID: 27730190 Basic Science of Electronic Cigarettes: Assessment in Cell Culture and in Vivo Models Respiratory Research. 10, 2016 | Pubmed ID: 27717371 ADAM17 and EGFR Regulate IL-6 Receptor and Amphiregulin MRNA Expression and Release in Cigarette Smoke-exposed Primary Bronchial Epithelial Cells from Patients with Chronic Obstructive Pulmonary Disease (COPD) Physiological Reports. Aug, 2016 | Pubmed ID: 27561911 Airway Hyperresponsiveness in Chronic Obstructive Pulmonary Disease: A marker of Asthma-chronic Obstructive Pulmonary Disease Overlap Syndrome? The Journal of Allergy and Clinical Immunology. Dec, 2016 | Pubmed ID: 27345171 The Dutch National Program for Respiratory Research The Lancet. Respiratory Medicine. May, 2016 | Pubmed ID: 27304557 Childhood Allergies and Asthma: New Insights on Environmental Exposures and Local Immunity at the Lung Barrier Current Opinion in Immunology. Oct, 2016 | Pubmed ID: 27254380 Azithromycin Differentially Affects the IL-13-induced Expression Profile in Human Bronchial Epithelial Cells Pulmonary Pharmacology & Therapeutics. Aug, 2016 | Pubmed ID: 27246785 Lung Function Decline in Asthma Patients with Elevated Bronchial CD8, CD4 and CD3 Cells The European Respiratory Journal. Aug, 2016 | Pubmed ID: 27230446 Cellular Response of Mucociliary Differentiated Primary Bronchial Epithelial Cells to Diesel Exhaust American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2016 | Pubmed ID: 27190060 Antimicrobial Peptide P60.4Ac-Containing Creams and Gel for Eradication of Methicillin-Resistant Staphylococcus Aureus from Cultured Skin and Airway Epithelial Surfaces Antimicrobial Agents and Chemotherapy. Jul, 2016 | Pubmed ID: 27114278 Regeneration of the Lung: Lung Stem Cells and the Development of Lung Mimicking Devices Respiratory Research. Apr, 2016 | Pubmed ID: 27107715 Neutrophil-derived Alpha Defensins Control Inflammation by Inhibiting Macrophage MRNA Translation Proceedings of the National Academy of Sciences of the United States of America. Apr, 2016 | Pubmed ID: 27044108 Murine Models of Cardiovascular Comorbidity in Chronic Obstructive Pulmonary Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Jun, 2016 | Pubmed ID: 26993520 Microbes and Asthma: Opportunities for Intervention The Journal of Allergy and Clinical Immunology. Mar, 2016 | Pubmed ID: 26947981 IL-13 and the Airway Epithelium. It Is All in the Genes American Journal of Respiratory and Critical Care Medicine. Feb, 2016 | Pubmed ID: 26871666 MicroRNA-223 Controls the Expression of Histone Deacetylase 2: a Novel Axis in COPD Journal of Molecular Medicine (Berlin, Germany). Jun, 2016 | Pubmed ID: 26864305 TNF-α and IL-1β-activated Human Mesenchymal Stromal Cells Increase Airway Epithelial Wound Healing in Vitro Via Activation of the Epidermal Growth Factor Receptor Respiratory Research. Jan, 2016 | Pubmed ID: 26753875 The Positive Prognostic Effect of Stromal CD8+ Tumor-infiltrating T Cells is Restrained by the Expression of HLA-E in Non-small Cell Lung Carcinoma Oncotarget. Jan, 2016 | Pubmed ID: 26658106 Antimicrobial Peptides and Innate Lung Defenses: Role in Infectious and Noninfectious Lung Diseases and Therapeutic Applications Chest. Feb, 2016 | Pubmed ID: 26502035 Regulation of YKL-40 Expression by Corticosteroids: Effect on Pro-inflammatory Macrophages in Vitro and Its Modulation in COPD in Vivo Respiratory Research. Dec, 2015 | Pubmed ID: 26696093 Prediction of Long-Term Benefits of Inhaled Steroids by Phenotypic Markers in Moderate-to-Severe COPD: A Randomized Controlled Trial PloS One. 2015 | Pubmed ID: 26659582 Parallel Activities and Interactions Between Antimicrobial Peptides and Complement in Host Defense at the Airway Epithelial Surface Molecular Immunology. Nov, 2015 | Pubmed ID: 26597202 Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment PloS One. 2015 | Pubmed ID: 26545199 Therapeutic Potential of Soluble Guanylate Cyclase Modulators in Neonatal Chronic Lung Disease American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2015 | Pubmed ID: 26432873 Prevention of Exacerbations in Patients with COPD and Vitamin D Deficiency Through Vitamin D Supplementation (PRECOVID): a Study Protocol BMC Pulmonary Medicine. Sep, 2015 | Pubmed ID: 26399451 Local and Systemic XAGE-1b-specific Immunity in Patients with Lung Adenocarcinoma Cancer Immunology, Immunotherapy : CII. Sep, 2015 | Pubmed ID: 26025564 Tiotropium Attenuates IL-13-induced Goblet Cell Metaplasia of Human Airway Epithelial Cells Thorax. Jul, 2015 | Pubmed ID: 25995156 Effect of Bariatric Surgery on Asthma Control, Lung Function and Bronchial and Systemic Inflammation in Morbidly Obese Subjects with Asthma Thorax. Jul, 2015 | Pubmed ID: 25934136 Vitamin D, Vitamin D Binding Protein, and Longitudinal Outcomes in COPD PloS One. 2015 | Pubmed ID: 25803709 Brown Fat Activation Reduces Hypercholesterolaemia and Protects from Atherosclerosis Development Nature Communications. Mar, 2015 | Pubmed ID: 25754609 Basal Cells Contribute to Innate Immunity of the Airway Epithelium Through Production of the Antimicrobial Protein RNase 7 Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25712218 The Innate Immune Function of Airway Epithelial Cells in Inflammatory Lung Disease The European Respiratory Journal. Apr, 2015 | Pubmed ID: 25700381 Asthma-COPD Overlap. Clinical Relevance of Genomic Signatures of Type 2 Inflammation in Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Apr, 2015 | Pubmed ID: 25611785 Genome-Wide Association Study Identification of Novel Loci Associated with Airway Responsiveness in Chronic Obstructive Pulmonary Disease American Journal of Respiratory Cell and Molecular Biology. Aug, 2015 | Pubmed ID: 25514360 Brown Adipose Tissue Takes Up Plasma Triglycerides Mostly After Lipolysis Journal of Lipid Research. Jan, 2015 | Pubmed ID: 25351615 Function of Monocytes and Monocyte-derived Macrophages in α1-antitrypsin Deficiency The European Respiratory Journal. Feb, 2015 | Pubmed ID: 25323228 Dissecting the Genetics of Chronic Mucus Hypersecretion in Smokers with and Without COPD The European Respiratory Journal. Jan, 2015 | Pubmed ID: 25234806 Efficient and Sensitive Identification and Quantification of Airborne Pollen Using Next-generation DNA Sequencing Molecular Ecology Resources. Jan, 2015 | Pubmed ID: 24893805 Muscarinic M3 Receptors on Structural Cells Regulate Cigarette Smoke-induced Neutrophilic Airway Inflammation in Mice American Journal of Physiology. Lung Cellular and Molecular Physiology. Nov, 2014 | Pubmed ID: 25381025 Reproducibility of Exhaled Nitric Oxide Measurements in Overweight and Obese Adults BMC Research Notes. Nov, 2014 | Pubmed ID: 25366981 Club Cells, CC10 and Self-control at the Epithelial Surface The European Respiratory Journal. Oct, 2014 | Pubmed ID: 25271220 Genome-wide Association Analysis Identifies Six New Loci Associated with Forced Vital Capacity Nature Genetics. Jul, 2014 | Pubmed ID: 24929828 LL-37-derived Peptides Eradicate Multidrug-resistant Staphylococcus Aureus from Thermally Wounded Human Skin Equivalents Antimicrobial Agents and Chemotherapy. Aug, 2014 | Pubmed ID: 24841266 Susceptibility to Chronic Mucus Hypersecretion, a Genome Wide Association Study PloS One. 2014 | Pubmed ID: 24714607 Steroid Resistance in COPD? Overlap and Differential Anti-inflammatory Effects in Smokers and Ex-smokers PloS One. 2014 | Pubmed ID: 24505290 Recent Progress in Peptide Vaccination in Cancer with a Focus on Non-small-cell Lung Cancer Expert Review of Vaccines. Jan, 2014 | Pubmed ID: 24308580 Increased ERK Signalling Promotes Inflammatory Signalling in Primary Airway Epithelial Cells Expressing Z α1-antitrypsin Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24097797 Airway Gene Expression in COPD is Dynamic with Inhaled Corticosteroid Treatment and Reflects Biological Pathways Associated with Disease Activity Thorax. Jan, 2014 | Pubmed ID: 23925644 Development and Validation of a 5-day-ahead Hay Fever Forecast for Patients with Grass-pollen-induced Allergic Rhinitis International Journal of Biometeorology. Aug, 2014 | Pubmed ID: 23780494 PH in Exhaled Breath Condensate and Nasal Lavage As a Biomarker of Air Pollution-related Inflammation in Street Traffic-controllers and Office-workers Clinics (Sao Paulo, Brazil). Dec, 2013 | Pubmed ID: 24473505 The Effect of PPE-induced Emphysema and Chronic LPS-induced Pulmonary Inflammation on Atherosclerosis Development in APOE*3-LEIDEN Mice PloS One. 2013 | Pubmed ID: 24303000 Increase in Net Activity of Serine Proteinases but Not Gelatinases After Local Endotoxin Exposure in the Peripheral Airways of Healthy Subjects PloS One. 2013 | Pubmed ID: 24086430 Development of a Nose Cream Containing the Synthetic Antimicrobial Peptide P60.4Ac for Eradication of Methicillin-resistant Staphylococcus Aureus Carriage Journal of Pharmaceutical Sciences. Oct, 2013 | Pubmed ID: 23955373 Inhaled Steroids Modulate Extracellular Matrix Composition in Bronchial Biopsies of COPD Patients: a Randomized, Controlled Trial PloS One. 2013 | Pubmed ID: 23667615 CD8(+) T Cells Characterize Early Smoking-related Airway Pathology in Patients with Asthma Respiratory Medicine. Jul, 2013 | Pubmed ID: 23639272 Systemic Inflammation and Lung Function Impairment in Morbidly Obese Subjects with the Metabolic Syndrome Journal of Obesity. 2013 | Pubmed ID: 23509614 Resveratrol Protects Against Atherosclerosis, but Does Not Add to the Antiatherogenic Effect of Atorvastatin, in APOE*3-Leiden.CETP Mice The Journal of Nutritional Biochemistry. Aug, 2013 | Pubmed ID: 23337345 Profiling the Proteome of Exhaled Breath Condensate in Healthy Smokers and COPD Patients by LC-MS/MS International Journal of Molecular Sciences. Oct, 2012 | Pubmed ID: 23203040 Toll-like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease PloS One. 2012 | Pubmed ID: 22952638 α1-antitrypsin Production by Proinflammatory and Antiinflammatory Macrophages and Dendritic Cells American Journal of Respiratory Cell and Molecular Biology. May, 2012 | Pubmed ID: 22162908 A Quantitative Method for Detection of Spliced X-box Binding Protein-1 (XBP1) MRNA As a Measure of Endoplasmic Reticulum (ER) Stress Cell Stress & Chaperones. Mar, 2012 | Pubmed ID: 22038282 Hepatocyte-specific IKKβ Expression Aggravates Atherosclerosis Development in APOE*3-Leiden Mice Atherosclerosis. Feb, 2012 | Pubmed ID: 21798539 Difference in Symptom Severity Between Early and Late Grass Pollen Season in Patients with Seasonal Allergic Rhinitis Clinical and Translational Allergy. Dec, 2011 | Pubmed ID: 22410160 PRAME-specific Allo-HLA-restricted T Cells with Potent Antitumor Reactivity Useful for Therapeutic T-cell Receptor Gene Transfer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2011 | Pubmed ID: 21771875 IL-4 and IL-13 Exposure During Mucociliary Differentiation of Bronchial Epithelial Cells Increases Antimicrobial Activity and Expression of Antimicrobial Peptides Respiratory Research. May, 2011 | Pubmed ID: 21529380 Smoking Status and Anti-inflammatory Macrophages in Bronchoalveolar Lavage and Induced Sputum in COPD Respiratory Research. Mar, 2011 | Pubmed ID: 21426578 The Role of IREB2 and Transforming Growth Factor Beta-1 Genetic Variants in COPD: a Replication Case-control Study BMC Medical Genetics. Feb, 2011 | Pubmed ID: 21320324 Severe Congenital Neutropenia in a Multigenerational Family with a Novel Neutrophil Elastase (ELANE) Mutation Annals of Hematology. Feb, 2011 | Pubmed ID: 20803142 Pro-inflammatory Mechanisms of Muscarinic Receptor Stimulation in Airway Smooth Muscle Respiratory Research. Sep, 2010 | Pubmed ID: 20875145 LL-37 Directs Macrophage Differentiation Toward Macrophages with a Proinflammatory Signature Journal of Immunology (Baltimore, Md. : 1950). Aug, 2010 | Pubmed ID: 20610648 Multidrug Resistance-associated Protein-1 (MRP1) Genetic Variants, MRP1 Protein Levels and Severity of COPD Respiratory Research. May, 2010 | Pubmed ID: 20487524 Recent Advances in Alveolar Biology: Evolution and Function of Alveolar Proteins Respiratory Physiology & Neurobiology. Aug, 2010 | Pubmed ID: 20433956 Expression Patterns of Protein C Inhibitor in Mouse Development Journal of Molecular Histology. Feb, 2010 | Pubmed ID: 20229239 Association of MMP-2 Polymorphisms with Severe and Very Severe COPD: a Case Control Study of MMPs-1, 9 and 12 in a European Population BMC Medical Genetics. Jan, 2010 | Pubmed ID: 20078883 Effect of Fluticasone with and Without Salmeterol on Pulmonary Outcomes in Chronic Obstructive Pulmonary Disease: a Randomized Trial Annals of Internal Medicine. Oct, 2009 | Pubmed ID: 19841453 Comparison of Exhaled Breath Condensate PH Using Two Commercially Available Devices in Healthy Controls, Asthma and COPD Patients Respiratory Research. Aug, 2009 | Pubmed ID: 19703285 Expression of Smooth Muscle and Extracellular Matrix Proteins in Relation to Airway Function in Asthma The Journal of Allergy and Clinical Immunology. May, 2008 | Pubmed ID: 18405955 An Antimicrobial Peptide Modulates Epithelial Responses to Bacterial Products The Laryngoscope. May, 2008 | Pubmed ID: 18300705 The Role of Epithelial Beta-defensins and Cathelicidins in Host Defense of the Lung Experimental Lung Research. Dec, 2007 | Pubmed ID: 18075828 Reduction in Sputum Neutrophil and Eosinophil Numbers by the PDE4 Inhibitor Roflumilast in Patients with COPD Thorax. Dec, 2007 | Pubmed ID: 17573446 Human Neutrophil Peptide-1 Inhibits Both the Classical and the Lectin Pathway of Complement Activation Molecular Immunology. Jul, 2007 | Pubmed ID: 17448537 Óxido Nítrico Inhalado Atenúa La Inflamación Y Fibrina Pulmonar De La Deposición Y Prolonga La Supervivencia En La Lesión Pulmonar Hyperoxic Neonatal American Journal of Physiology. Lung Cellular and Molecular Physiology. Jul, 2007 | Pubmed ID: 17384081 Bronchial Inflammation and Airway Responses to Deep Inspiration in Asthma and Chronic Obstructive Pulmonary Disease American Journal of Respiratory and Critical Care Medicine. Jul, 2007 | Pubmed ID: 17379851 Demonstration of Bacterial Cells and Glycocalyx in Biofilms on Human Tonsils Archives of Otolaryngology--head & Neck Surgery. Feb, 2007 | Pubmed ID: 17309977 Small Airways Dysfunction and Neutrophilic Inflammation in Bronchial Biopsies and BAL in COPD Chest. Jan, 2007 | Pubmed ID: 17218556 Exploring Host-pathogen Interactions at the Epithelial Surface: Application of Transcriptomics in Lung Biology American Journal of Physiology. Lung Cellular and Molecular Physiology. Feb, 2007 | Pubmed ID: 17041013 Epithelial Differentiation is a Determinant in the Production of Eotaxin-2 and -3 by Bronchial Epithelial Cells in Response to IL-4 and IL-13 Molecular Immunology. Feb, 2007 | Pubmed ID: 16740309 Adenovirus-specific CD4+ T Cell Clones Recognizing Endogenous Antigen Inhibit Viral Replication in Vitro Through Cognate Interaction Journal of Immunology (Baltimore, Md. : 1950). Dec, 2006 | Pubmed ID: 17142788 The SERPINE2 Gene and Chronic Obstructive Pulmonary Disease American Journal of Human Genetics. Jul, 2006 | Pubmed ID: 16773582 The Antimicrobial Peptide LL-37 Enhances IL-8 Release by Human Airway Smooth Muscle Cells The Journal of Allergy and Clinical Immunology. Jun, 2006 | Pubmed ID: 16750994 Human Cathelicidin LL-37 is a Chemoattractant for Eosinophils and Neutrophils That Acts Via Formyl-peptide Receptors International Archives of Allergy and Immunology. 2006 | Pubmed ID: 16557028 A Molecular Signature of Epithelial Host Defense: Comparative Gene Expression Analysis of Cultured Bronchial Epithelial Cells and Keratinocytes BMC Genomics. Jan, 2006 | Pubmed ID: 16420688 Expression of Epidermal Growth Factors and Their Receptors in the Bronchial Epithelium of Subjects with Chronic Obstructive Pulmonary Disease American Journal of Clinical Pathology. Feb, 2006 | Pubmed ID: 16393673 Development of Novel LL-37 Derived Antimicrobial Peptides with LPS and LTA Neutralizing and Antimicrobial Activities for Therapeutic Application Peptides. Apr, 2006 | Pubmed ID: 16274847 Cytokine-dependent Proliferation of Human CD34+ Progenitor Cells in the Absence of Serum is Suppressed by Their Progeny's Production of Serine Proteinases Stem Cells (Dayton, Ohio). Feb, 2006 | Pubmed ID: 16109763 Effects of Cigarette Smoke Condensate on Proliferation and Wound Closure of Bronchial Epithelial Cells in Vitro: Role of Glutathione Respiratory Research. Nov, 2005 | Pubmed ID: 16309548 Bronchial CD8 Cell Infiltrate and Lung Function Decline in Asthma American Journal of Respiratory and Critical Care Medicine. Oct, 2005 | Pubmed ID: 16085937 Host Defense Effector Molecules in Mucosal Secretions FEMS Immunology and Medical Microbiology. Aug, 2005 | Pubmed ID: 16051067 The Human Cathelicidin LL-37: a Multifunctional Peptide Involved in Infection and Inflammation in the Lung Pulmonary Pharmacology & Therapeutics. 2005 | Pubmed ID: 15939310 Eotaxin-2 and Eotaxin-3 Expression is Associated with Persistent Eosinophilic Bronchial Inflammation in Patients with Asthma After Allergen Challenge The Journal of Allergy and Clinical Immunology. Apr, 2005 | Pubmed ID: 15805998 Transcriptional Response of Bronchial Epithelial Cells to Pseudomonas Aeruginosa: Identification of Early Mediators of Host Defense Physiological Genomics. May, 2005 | Pubmed ID: 15701729 Interactions Between Neutrophil-derived Antimicrobial Peptides and Airway Epithelial Cells Journal of Leukocyte Biology. Apr, 2005 | Pubmed ID: 15591123 TGF-beta Differentially Regulates TH2 Cytokine-induced Eotaxin and Eotaxin-3 Release by Human Airway Smooth Muscle Cells The Journal of Allergy and Clinical Immunology. Oct, 2004 | Pubmed ID: 15480317 Bacterial Products Increase Expression of the Human Cathelicidin HCAP-18/LL-37 in Cultured Human Sinus Epithelial Cells FEMS Immunology and Medical Microbiology. Oct, 2004 | Pubmed ID: 15364108 Perfil De Expresión Génica Y La Histopatología De La Displasia Broncopulmonar Experimental Inducida Por Estrés Oxidativo Prolongado Free Radical Biology & Medicine. Mar, 2004 | Pubmed ID: 14990357 Series Introduction: Innate Host Defense of the Respiratory Epithelium Journal of Leukocyte Biology. Jan, 2004 | Pubmed ID: 14612432 Neutrophil Defensins Enhance Lung Epithelial Wound Closure and Mucin Gene Expression in Vitro American Journal of Respiratory Cell and Molecular Biology. Feb, 2004 | Pubmed ID: 12871849 The Antimicrobial Peptide LL-37 Activates Innate Immunity at the Airway Epithelial Surface by Transactivation of the Epidermal Growth Factor Receptor Journal of Immunology (Baltimore, Md. : 1950). Dec, 2003 | Pubmed ID: 14662872 Rhinovirus Increases Human Beta-defensin-2 and -3 MRNA Expression in Cultured Bronchial Epithelial Cells FEMS Immunology and Medical Microbiology. Aug, 2003 | Pubmed ID: 12900056 Are Rhinovirus-induced Airway Responses in Asthma Aggravated by Chronic Allergen Exposure? American Journal of Respiratory and Critical Care Medicine. Nov, 2003 | Pubmed ID: 12893645 An Angiogenic Role for the Human Peptide Antibiotic LL-37/hCAP-18 The Journal of Clinical Investigation. Jun, 2003 | Pubmed ID: 12782669 Expression of Beta-defensin 1 and 2 MRNA by Human Monocytes, Macrophages and Dendritic Cells Immunology. Aug, 2002 | Pubmed ID: 12153515 World Congress on Lung Health and 10th ERS Annual Congress 30 August-3 September 2000, Florence, Italy Respiratory Research. 2000 | Pubmed ID: 11667983 Aislar células epiteliales bronquiales del tejido pulmonar resecado para biobancos y establecer cultivos de interfaz aire-líquido bien diferenciados Dennis K. Ninaber1, Anne M. van der Does1, Pieter S. Hiemstra1 1PulmoScience Laboratory, Department of Pulmonology, Leiden University Medical Center JoVE 65102 Inmunología e infección
Aislar células epiteliales bronquiales del tejido pulmonar resecado para biobancos y establecer cultivos de interfaz aire-líquido bien diferenciados Dennis K. Ninaber1, Anne M. van der Does1, Pieter S. Hiemstra1 1PulmoScience Laboratory, Department of Pulmonology, Leiden University Medical Center JoVE 65102 Inmunología e infección