Steven L. Carroll Department of Pathology and Laboratory Medicine Medical University of South Carolina Biography Publications Institution JoVE Articles Steven L. Carroll has not added a biography. If you are Steven L. Carroll and would like to personalize this page please email our Author Liaison for assistance. Publications Down Syndrome Biobank Consortium: A Perspective Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2024 | Pubmed ID: 38270275 Inhibition of Erb-B2 Receptor Tyrosine Kinase 3 and Associated Regulatory Pathways Potently Impairs Malignant Peripheral Nerve Sheath Tumor Proliferation and Survival The American Journal of Pathology. Sep, 2023 | Pubmed ID: 37328102 LPAR1 and Aberrantly Expressed LPAR3 Differentially Promote the Migration and Proliferation of Malignant Peripheral Nerve Sheath Tumor Cells Glia. Mar, 2023 | Pubmed ID: 36416236 Priorities in Biobanking Research: A Report on the 2021 ISBER Round Table Biopreservation and Biobanking. Feb, 2023 | Pubmed ID: 35507966 Developmental, Neurochemical, and Behavioral Analyses of ErbB4 Cyt-1 Knockout Mice Journal of Neurochemistry. Jun, 2022 | Pubmed ID: 35523590 The RASopathies: Biology, Genetics and Therapeutic Options Advances in Cancer Research. 2022 | Pubmed ID: 35101235 Suppression of Fli-1 Protects Against Pericyte Loss and Cognitive Deficits in Alzheimer's Disease Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2022 | Pubmed ID: 35038582 R-Ras Subfamily Proteins Elicit Distinct Physiologic Effects and Phosphoproteome Alterations in Neurofibromin-null MPNST Cells Cell Communication and Signaling : CCS. Sep, 2021 | Pubmed ID: 34530870 The Role of R-Ras Proteins in Normal and Pathologic Migration and Morphologic Change The American Journal of Pathology. Sep, 2021 | Pubmed ID: 34111428 The Potential Role of Small-Molecule PERK Inhibitor LDN-0060609 in Primary Open-Angle Glaucoma Treatment International Journal of Molecular Sciences. Apr, 2021 | Pubmed ID: 33925820 Establishment and Genomic Characterization of a Sporadic Malignant Peripheral Nerve Sheath Tumor Cell Line Scientific Reports. Mar, 2021 | Pubmed ID: 33707600 Each Patient is a Research Biorepository: Informatics-enabled Research on Surplus Clinical Specimens Via the Living BioBank Journal of the American Medical Informatics Association : JAMIA. 01, 2021 | Pubmed ID: 33166379 Chemoembolizing Hepatocellular Carcinoma with Microsphere Cored with Arsenic Trioxide Microcrystal Drug Delivery. Nov, 2020 | Pubmed ID: 33307843 Assessing Interobserver Variability and Accuracy in the Histological Diagnosis and Classification of Cutaneous Neurofibromass Neuro-oncology Advances. Jul, 2020 | Pubmed ID: 32642737 Serum Pro-BDNF Levels Correlate with Phospho-tau Staining in Alzheimer's Disease Neurobiology of Aging. 03, 2020 | Pubmed ID: 31882186 Salinomycin Targets the Genome of Radioresistant Cells in Glioblastomas Neuro-oncology. 02, 2020 | Pubmed ID: 31784742 The Proteome of the Dentate Terminal Zone of the Perforant Path Indicates Presynaptic Impairment in Alzheimer Disease Molecular & Cellular Proteomics : MCP. 01, 2020 | Pubmed ID: 31699905 Mechanisms of Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3) Action in Human Neoplasia The American Journal of Pathology. 10, 2019 | Pubmed ID: 31351986 ErbB4 Promotes Malignant Peripheral Nerve Sheath Tumor Pathogenesis Via Ras-independent Mechanisms Cell Communication and Signaling : CCS. 07, 2019 | Pubmed ID: 31291965 The Evolution and Multi-molecular Properties of NF1 Cutaneous Neurofibromas Originating from C-fiber Sensory Endings and Terminal Schwann Cells at Normal Sites of Sensory Terminations in the Skin PloS One. 2019 | Pubmed ID: 31107888 Complex Patterns of GABAergic Neuronal Deficiency and Type 2 Potassium-Chloride Cotransporter Immaturity in Human Focal Cortical Dysplasia Journal of Neuropathology and Experimental Neurology. 04, 2019 | Pubmed ID: 30856249 Cutaneous Neurofibromas: Current Clinical and Pathologic Issues Neurology. 07, 2018 | Pubmed ID: 29987130 Oridonin Inhibits Aberrant AKT Activation in Breast Cancer Oncotarget. May, 2018 | Pubmed ID: 29844859 Pathology of NNOS-Expressing GABAergic Neurons in Mouse Model of Alzheimer's Disease Neuroscience. 08, 2018 | Pubmed ID: 29782905 Recent Advances in the Diagnosis and Pathogenesis of Neurofibromatosis Type 1 (NF1)-associated Peripheral Nervous System Neoplasms Advances in Anatomic Pathology. Sep, 2018 | Pubmed ID: 29762158 Rare Coding Variants in PLCG2, ABI3, and TREM2 Implicate Microglial-mediated Innate Immunity in Alzheimer's Disease Nature Genetics. 09, 2017 | Pubmed ID: 28714976 The Molecular and Morphologic Structures That Make Saltatory Conduction Possible in Peripheral Nerve Journal of Neuropathology and Experimental Neurology. 04, 2017 | Pubmed ID: 28340093 BH3 Mimetics Suppress CXCL12 Expression in Human Malignant Peripheral Nerve Sheath Tumor Cells Oncotarget. Jan, 2017 | Pubmed ID: 28055968 Neuronal Exosomes Reveal Alzheimer's Disease Biomarkers in Down Syndrome Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2017 | Pubmed ID: 27755974 Current Status and Recommendations for Biomarkers and Biobanking in Neurofibromatosis Neurology. Aug, 2016 | Pubmed ID: 27527649 STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells Molecular Cancer Research : MCR. 05, 2016 | Pubmed ID: 26883073 The Challenge of Cancer Genomics in Rare Nervous System Neoplasms: Malignant Peripheral Nerve Sheath Tumors As a Paradigm for Cross-Species Comparative Oncogenomics The American Journal of Pathology. Mar, 2016 | Pubmed ID: 26740486 Classic Ras Proteins Promote Proliferation and Survival Via Distinct Phosphoproteome Alterations in Neurofibromin-Null Malignant Peripheral Nerve Sheath Tumor Cells Journal of Neuropathology and Experimental Neurology. Jun, 2015 | Pubmed ID: 25946318 Combinatorial Therapy with Tamoxifen and Trifluoperazine Effectively Inhibits Malignant Peripheral Nerve Sheath Tumor Growth by Targeting Complementary Signaling Cascades Journal of Neuropathology and Experimental Neurology. Nov, 2014 | Pubmed ID: 25289889 Common Genetic Variants in the CLDN2 and PRSS1-PRSS2 Loci Alter Risk for Alcohol-related and Sporadic Pancreatitis Nature Genetics. Nov, 2012 | Pubmed ID: 23143602 The Pan ErbB Inhibitor PD168393 Enhances Lysosomal Dysfunction-induced Apoptotic Death in Malignant Peripheral Nerve Sheath Tumor Cells Neuro-oncology. Jan, 2012 | Pubmed ID: 22259051 Molecular Mechanisms Promoting the Pathogenesis of Schwann Cell Neoplasms Acta Neuropathologica. Dec, 2011 | Pubmed ID: 22160322 Genetically Engineered Mouse Models Shed New Light on the Pathogenesis of Neurofibromatosis Type I-related Neoplasms of the Peripheral Nervous System Brain Research Bulletin. Aug, 2011 | Pubmed ID: 21855613 Common Variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 Are Associated with Late-onset Alzheimer's Disease Nature Genetics. May, 2011 | Pubmed ID: 21460841 Tamoxifen Inhibits Malignant Peripheral Nerve Sheath Tumor Growth in an Estrogen Receptor-independent Manner Neuro-oncology. Jan, 2011 | Pubmed ID: 21075781 Common Variants at 7p21 Are Associated with Frontotemporal Lobar Degeneration with TDP-43 Inclusions Nature Genetics. Mar, 2010 | Pubmed ID: 20154673 Neuregulin-1 Beta and Neuregulin-1 Alpha Differentially Affect the Migration and Invasion of Malignant Peripheral Nerve Sheath Tumor Cells Glia. Nov, 2009 | Pubmed ID: 19306381 How Does the Schwann Cell Lineage Form Tumors in NF1? Glia. Nov, 2008 | Pubmed ID: 18803326 Differential Activation of C-fos and Caspase-3 in Hippocampal Neuron Subpopulations Following Neonatal Hypoxia-ischemia Journal of Neuroscience Research. Apr, 2008 | Pubmed ID: 18030677 BH3-only Proapoptotic Bcl-2 Family Members Noxa and Puma Mediate Neural Precursor Cell Death The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2006 | Pubmed ID: 16822983 Interactions Between Beta-neuregulin and Neurotrophins in Motor Neuron Apoptosis Journal of Neurochemistry. Apr, 2006 | Pubmed ID: 16524373 Neuregulin Growth Factors and Their ErbB Receptors Form a Potential Signaling Network for Schwannoma Tumorigenesis Journal of Neuropathology and Experimental Neurology. Feb, 2006 | Pubmed ID: 16462207 Activation of the Neuregulin-1/ErbB Signaling Pathway Promotes the Proliferation of Neoplastic Schwann Cells in Human Malignant Peripheral Nerve Sheath Tumors Oncogene. Aug, 2005 | Pubmed ID: 15897877 Neuregulin-1 Enhances Survival of Human Astrocytic Glioma Cells Glia. Aug, 2005 | Pubmed ID: 15812817 Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-associated Peripheral Nerve Sheath Tumors: II. The Role of Dysregulated Growth Factor Signaling Journal of Neuropathology and Experimental Neurology. Jan, 2005 | Pubmed ID: 15715079 Improved Gene Delivery into Neuroglial Cells Using a Fiber-modified Adenovirus Vector Biochemical and Biophysical Research Communications. Mar, 2005 | Pubmed ID: 15708001 Ganglion-specific Patterns of Diabetes-modulated Gene Expression Are Established in Prevertebral and Paravertebral Sympathetic Ganglia Prior to the Development of Neuroaxonal Dystrophy Journal of Neuropathology and Experimental Neurology. Nov, 2004 | Pubmed ID: 15581182 Tumor Suppressor Mutations and Growth Factor Signaling in the Pathogenesis of NF1-associated Peripheral Nerve Sheath Tumors. I. The Role of Tumor Suppressor Mutations Journal of Neuropathology and Experimental Neurology. Nov, 2004 | Pubmed ID: 15581179 Neuregulin-1beta Induces Neurite Extension and Arborization in Cultured Hippocampal Neurons Molecular and Cellular Neurosciences. Dec, 2004 | Pubmed ID: 15555917 ErbB Transmembrane Tyrosine Kinase Receptors Are Expressed by Sensory and Motor Neurons Projecting into Sciatic Nerve The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. Oct, 2004 | Pubmed ID: 15385576 Constitutive Activation of the Neuregulin-1/erbB Signaling Pathway Promotes the Proliferation of a Human Peripheral Neuroepithelioma Cell Line Journal of Neuro-oncology. Feb, 2004 | Pubmed ID: 15015657 Hypertrophic Neuropathies and Malignant Peripheral Nerve Sheath Tumors in Transgenic Mice Overexpressing Glial Growth Factor Beta3 in Myelinating Schwann Cells The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2003 | Pubmed ID: 12917360 Constitutive Activation of the Neuregulin-1/ErbB Receptor Signaling Pathway is Essential for the Proliferation of a Neoplastic Schwann Cell Line Glia. Aug, 2003 | Pubmed ID: 12838503 Lysophosphatidic Acid Promotes the Proliferation of Adult Schwann Cells Isolated from Axotomized Sciatic Nerve Journal of Neuropathology and Experimental Neurology. May, 2003 | Pubmed ID: 12769191 Neuregulin-1 Enhances Motility and Migration of Human Astrocytic Glioma Cells The Journal of Biological Chemistry. Jun, 2003 | Pubmed ID: 12600989 Neuregulin-1 and ErbB4 Immunoreactivity is Associated with Neuritic Plaques in Alzheimer Disease Brain and in a Transgenic Model of Alzheimer Disease Journal of Neuropathology and Experimental Neurology. Jan, 2003 | Pubmed ID: 12528817 Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors Dorea P. Jenkins1, Brittany Turner-Ivey1,2, Jody Fromm Longo1, Steven L. Carroll1,2 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2Hollings Cancer Center, Medical University of South Carolina JoVE 65740 Investigación sobre el cáncer Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens (Video) | JoVE Brittany Turner-Ivey1, Jody Fromm Longo2, Dorea P. Jenkins2, Stephen T. Guest3, Steven L. Carroll1,2 1Hollings Cancer Center, Medical University of South Carolina, 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 3Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor JoVE 65430 Investigación sobre el cáncer Definindo funções genéticas em Tumorigênese por Ex vivo Ablaation of Floxed Alleles in Maligna Periférico Nerve Hemato Tumor Cells Jody Fromm Longo1, Stephanie N. Brosius2,3, Steven L. Carroll1 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2Department of Pediatrics and Neurology, Perelman School of Medicine of the University of Pennsylvania, 3Division of Child Neurology, Children's Hospital of Philadelphia JoVE 62740 Investigación sobre el cáncer Ortotópico do xeno-Human-luciferase Tagged maligna dos nervos periféricos Células Tumorais Bainha para In vivo Teste de Agentes Terapêuticos candidatos Amy N. Turk1, Stephanie J. Byer1, Kurt R. Zinn2, Steven L. Carroll1,3 1Department of Pathology, University of Alabama at Birmingham - UAB, 2Department of Radiology, University of Alabama at Birmingham - UAB, 3Department of Cell Biology and Neurobiology, University of Alabama at Birmingham - UAB JoVE 2558 Medicina
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors Dorea P. Jenkins1, Brittany Turner-Ivey1,2, Jody Fromm Longo1, Steven L. Carroll1,2 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2Hollings Cancer Center, Medical University of South Carolina JoVE 65740 Investigación sobre el cáncer
Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens (Video) | JoVE Brittany Turner-Ivey1, Jody Fromm Longo2, Dorea P. Jenkins2, Stephen T. Guest3, Steven L. Carroll1,2 1Hollings Cancer Center, Medical University of South Carolina, 2Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 3Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor JoVE 65430 Investigación sobre el cáncer
Definindo funções genéticas em Tumorigênese por Ex vivo Ablaation of Floxed Alleles in Maligna Periférico Nerve Hemato Tumor Cells Jody Fromm Longo1, Stephanie N. Brosius2,3, Steven L. Carroll1 1Department of Pathology and Laboratory Medicine, Medical University of South Carolina, 2Department of Pediatrics and Neurology, Perelman School of Medicine of the University of Pennsylvania, 3Division of Child Neurology, Children's Hospital of Philadelphia JoVE 62740 Investigación sobre el cáncer
Ortotópico do xeno-Human-luciferase Tagged maligna dos nervos periféricos Células Tumorais Bainha para In vivo Teste de Agentes Terapêuticos candidatos Amy N. Turk1, Stephanie J. Byer1, Kurt R. Zinn2, Steven L. Carroll1,3 1Department of Pathology, University of Alabama at Birmingham - UAB, 2Department of Radiology, University of Alabama at Birmingham - UAB, 3Department of Cell Biology and Neurobiology, University of Alabama at Birmingham - UAB JoVE 2558 Medicina
