Toshiki Ochi Princess Margaret Cancer Centre University Health Network Biography Publications Institution JoVE Articles Toshiki Ochi has not added a biography. If you are Toshiki Ochi and would like to personalize this page please email our Author Liaison for assistance. Publications BET Bromodomain Inhibition Enhances T Cell Persistence and Function in Adoptive Immunotherapy Models The Journal of Clinical Investigation. Sep, 2016 | Pubmed ID: 27548527 Mouse and Human CD1d-Self-Lipid Complexes Are Recognized Differently by Murine Invariant Natural Killer T Cell Receptors PloS One. 2016 | Pubmed ID: 27213277 CD4(+) and CD8(+) TCRβ Repertoires Possess Different Potentials to Generate Extraordinarily High-avidity T Cells Scientific Reports. Mar, 2016 | Pubmed ID: 27030642 CDR3β Sequence Motifs Regulate Autoreactivity of Human Invariant NKT Cell Receptors Journal of Autoimmunity. Apr, 2016 | Pubmed ID: 26748722 Induction of WT1-specific Human CD8+ T Cells from Human HSCs in HLA Class I Tg NOD/SCID/IL2rgKO Mice Blood. Feb, 2016 | Pubmed ID: 26702062 Optimization of T-cell Reactivity by Exploiting TCR Chain Centricity for the Purpose of Safe and Effective Antitumor TCR Gene Therapy Cancer Immunology Research. Sep, 2015 | Pubmed ID: 25943533 Specific Roles of Each TCR Hemichain in Generating Functional Chain-centric TCR Journal of Immunology (Baltimore, Md. : 1950). Apr, 2015 | Pubmed ID: 25710913 Adoptive Transfer of Genetically Engineered WT1-specific Cytotoxic T Lymphocytes Does Not Induce Renal Injury Journal of Hematology & Oncology. Jan, 2014 | Pubmed ID: 24393438 Development of a Novel Redirected T-cell-based Adoptive Immunotherapy Targeting Human Telomerase Reverse Transcriptase for Adult T-cell Leukemia Blood. Jun, 2013 | Pubmed ID: 23641014 Co-introduced Functional CCR2 Potentiates in Vivo Anti-lung Cancer Functionality Mediated by T Cells Double Gene-modified to Express WT1-specific T-cell Receptor PloS One. 2013 | Pubmed ID: 23441216 Aurora Kinase A-specific T-cell Receptor Gene Transfer Redirects T Lymphocytes to Display Effective Antileukemia Reactivity Blood. Jan, 2012 | Pubmed ID: 22025529 Novel Adoptive T-cell Immunotherapy Using a WT1-specific TCR Vector Encoding Silencers for Endogenous TCRs Shows Marked Antileukemia Reactivity and Safety Blood. Aug, 2011 | Pubmed ID: 21673345 Gemcitabine Enhances Wilms' Tumor Gene WT1 Expression and Sensitizes Human Pancreatic Cancer Cells with WT1-specific T-cell-mediated Antitumor Immune Response Cancer Immunology, Immunotherapy : CII. Sep, 2011 | Pubmed ID: 21607557 Requisite Considerations for Successful Adoptive Immunotherapy with Engineered T-lymphocytes Using Tumor Antigen-specific T-cell Receptor Gene Transfer Expert Opinion on Biological Therapy. Jun, 2011 | Pubmed ID: 21413911 Adoptive T-cell Immunotherapy Using T-cell Receptor Gene Transfer: Aiming at a Cure for Cancer Immunotherapy. Feb, 2011 | Pubmed ID: 21322752 Activation of T-cell Receptor Signaling in Peripheral T-cell Lymphoma Cells Plays an Important Role in the Development of Lymphoma-associated Hemophagocytosis International Journal of Hematology. Feb, 2011 | Pubmed ID: 21229399 Subtypes of Familial Hemophagocytic Lymphohistiocytosis in Japan Based on Genetic and Functional Analyses of Cytotoxic T Lymphocytes PloS One. Nov, 2010 | Pubmed ID: 21152410 Generation of Functional Human T-cell Subsets with HLA-restricted Immune Responses in HLA Class I Expressing NOD/SCID/IL2r Gamma(null) Humanized Mice Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20615947 Human Herpesvirus 6 Infection Impairs Toll-like Receptor Signaling Virology Journal. May, 2010 | Pubmed ID: 20459723 Application of Adoptive T-cell Therapy Using Tumor Antigen-specific T-cell Receptor Gene Transfer for the Treatment of Human Leukemia Journal of Biomedicine & Biotechnology. 2010 | Pubmed ID: 20454585 Germ Cell Tumor Concomitant with Acquired Immune Deficiency Syndrome Internal Medicine (Tokyo, Japan). 2009 | Pubmed ID: 20009406 Aurora-A Kinase: a Novel Target Both for Cellular Immunotherapy and Molecular Target Therapy Against Human Leukemia Expert Opinion on Therapeutic Targets. Dec, 2009 | Pubmed ID: 19821797 HBZ is an Immunogenic Protein, but Not a Target Antigen for Human T-cell Leukemia Virus Type 1-specific Cytotoxic T Lymphocytes The Journal of General Virology. Aug, 2009 | Pubmed ID: 19423550 Identification of a Novel Epitope Derived from CML66 That is Recognized by Anti-leukaemia Cytotoxic T Lymphocytes British Journal of Haematology. Jun, 2009 | Pubmed ID: 19388930 Clinical Efficacy of WT1 Peptide Vaccination in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome American Journal of Hematology. May, 2009 | Pubmed ID: 19338044 Aurora-A Kinase: a Novel Target of Cellular Immunotherapy for Leukemia Blood. Jan, 2009 | Pubmed ID: 18820130 Identification of an Epitope Derived from CML66, a Novel Tumor-associated Antigen Expressed Broadly in Human Leukemia, Recognized by Human Leukocyte Antigen-A*2402-restricted Cytotoxic T Lymphocytes Cancer Science. Jul, 2008 | Pubmed ID: 18422754 Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Inmunología e infección
Generating De Novo Antigen-specific Human T Cell Receptors by Retroviral Transduction of Centric Hemichain Tingxi Guo1,2, Toshiki Ochi*2, Munehide Nakatsugawa*2, Yuki Kagoya2, Mark Anczurowski1,2, Chung-Hsi Wang1,2, Muhammed A. Rahman2, Kayoko Saso2, Marcus O. Butler1,2, Naoto Hirano1,2 1Department of Immunology, University of Toronto, 2Princess Margaret Cancer Centre, University Health Network JoVE 54697 Inmunología e infección