Magnetic Particle Probes
Magnetic Particle Probes - Related Videos
07:01
Frequency Mixing Magnetic Detection Scanner for Imaging Magnetic Particles in Planar Samples
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Cited by 5 •
2016
A scanner for imaging magnetic particles in planar samples was developed using the planar frequency mixing magnetic detection technique. The magnetic intermodulation product response from the nonlinear nonhysteretic magnetization of the particles is recorded upon a two-frequency excitation. It can be used to take 2D images of thin biological samples.
03:06
Growth and Differentiation of Magnetic Nano Particle-Loaded Neurons on Magnetic Platforms
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2025
This video demonstrates the uptake of fluorescent magnetic nanoparticles (MNPs) by the neuronal cells via endocytosis. Growing these MNP-loaded neurons on the magnetically patterned substrate enables the attachment of the cells. The addition of a growth factor containing medium aids in the growth of neuron extensions, while the magnetic field of the substrate directs the orientation of the extension.
03:43
A Technique for Magnetic Glass Particle-Mediated Nucleic Acid Extraction from Blood
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2025
This video demonstrates a technique for nucleic acid extraction from whole human blood using magnetic glass particles (MGPs) — small magnetic beads coated with silica. Upon lysing the blood cells using a lysis buffer, the released nucleic acids bind to the surface of silica-coated MGPs, extracting the molecules from the sample.
13:15
Quantitative and Qualitative Examination of Particle-particle Interactions Using Colloidal Probe Nanoscopy
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Cited by 3 •
2014
Colloidal probe nanoscopy can be used within a variety of fields to gain insight into the physical stability and coagulation kinetics of colloidal systems and aid in drug discovery and formulation sciences using biological systems. The method described within provides a quantitative and qualitative means to study such systems.
14:42
Remote Magnetic Actuation of Micrometric Probes for in situ 3D Mapping of Bacterial Biofilm Physical Properties
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Cited by 6 •
2014
This paper shows an original methodology based on the remote actuation of magnetic particles seeded in a bacterial biofilm and the development of dedicated magnetic tweezers to measure in situ the local mechanical properties of the complex living material built by micro-organisms at interfaces.
FAQs
Selectivity comes from functionalizing the particle surface with antibodies, peptides, or other binding molecules chosen to recognize a biological target. These surface ligands allow probes to attach to particular cells, proteins, or nucleic acids rather than interacting indiscriminately. The resulting attachment connects a specific molecular event to a magnetic response that can be measured or acted upon.
An applied magnetic field can move the probes, concentrate them, or enable their manipulation after they bind biological targets. This control makes the particles useful for directing probe-target complexes and changing their location within an experimental system. Depending on the intended task, magnetic control supports separation, purification, targeted delivery, or cell manipulation rather than serving only as a detection aid.
When a probe binds a cell, protein, or nucleic acid, the interaction changes the magnetic behavior of the probe-containing system. Researchers can use that change as a readout of the biological event, while cellular forces can likewise be translated into magnetic signals. This principle links molecular recognition or force measurement with quantitative biosensing and biological analysis.
A typical workflow begins by selecting a particle and attaching an appropriate antibody, peptide, or other binding molecule. The functionalized probes are then introduced to the biological targets, allowing selective attachment. Researchers apply a magnetic field to move, concentrate, manipulate, or measure the probes, and interpret the resulting magnetic response according to the experimental objective.
These probes are suited to tasks that require selective capture, positioning, delivery, or measurement of biological material. Supported applications include separation and purification, biosensing, targeted delivery, cell manipulation, and imaging. Their value depends on combining target-specific attachment with magnetic control, allowing one engineered particle system to perform different roles across diagnostic, therapeutic, and bioengineering studies.
In imaging, magnetic responses from the probes can provide information about biological targets, including through magnetic resonance-based methods. In tissue-engineering research, magnetic manipulation offers a way to study or influence cells within engineered biological systems. Together, these capabilities help connect spatial or force-related measurements with the development of diagnostic, therapeutic, and tissue-focused technologies.