Sterile Sutures

Sterile sutures are medical materials used to approximate and secure tissue edges while minimizing the introduction of microorganisms during wound closure. They work by maintaining controlled tension across an incision; absorbable sutures gradually break down through hydrolysis or enzymatic processes, whereas nonabsorbable sutures remain until removed or permanently incorporated into tissue. In cancer research, sterile sutures support closure after tumor excision, biopsy, and implantation procedures in animal models and clinical studies. Their material, structure, and absorption profile can influence inflammation, wound healing, infection risk, and the reliability of postoperative assessments, making appropriate suture selection important for reproducible research outcomes.

Sterile Sutures - Related Videos

Education

JoVE Science Education - Basic Biology

Sterile Tissue Harvest

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2016

Source: Kay Stewart, RVT, RLATG, CMAR; Valerie A. Schroeder, RVT, RLATG. University of Notre Dame, IN In 1959 The 3 R's were introduced by W.M.S. Russell and R.L. Burch in their book The Principles of Humane Experimental Technique. The 3 R's are replacement, reduction, and refinement of the use of animals in research. The use of cell lines and tissue cultures that originated from research animals is a replacement technique, as it allows for many experiments to be conducted in vitro. Harvesting...

Cleaning, Sterilization, and Disinfection

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2023

Cleaning, disinfection, and sterilization are the methods that help to break the infection chain and prevent disease. Cleaning The cleaning process usually involves using water with detergents or enzymatic cleaner and removing foreign material from objects and surfaces, including organic material such as body fluids or inorganic material like soil. Cleaning is performed before high-level disinfection and sterilization because foreign materials on the cover of the devices interfere with process...

Research

JoVE EoE - Large Animal Models

Q Suture Technique: A Suturing Technique to Reduce Gap Formation and Increase Tensile Strength in Tendon Repair

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2025

In this video, we demonstrate suturing techniques — core suture and Q suture — to repair the foot flexor tendon in an ex vivo porcine model. Q sutures enhance the strength of the core suture in tendon repair and decrease gapping at the tendon repair site.

Methods of Sterilization II: Chemical Methods

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2023

In healthcare, the chemical method of sterilization uses chemical sterilants to treat surgical instruments and medical supplies to help prevent the transmission of infectious pathogens to patients. Due to heat sensitivity, most medical supplies and equipment should not be exposed to high temperatures. These parts include rubber, plastic, glass, and other similar elements. Using chemical sterilization rather than heat to clean out equipment is recommended. It eradicates and removes all bacteria,...

Sutures of the Skull

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2025

The human skull is composed of several bones that come together to protect the brain and support the structures of the face. The junctions where these bones meet are called sutures. Sutures are immobile joints between adjacent bones of the skull. The narrow gap between the bones is filled with dense, fibrous connective tissue that unites the bones. The long sutures located between the skull bones are not straight but instead follow irregular, tightly twisting paths. These twisting lines tightly...

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