Solid Lipid Nanoparticles
Solid Lipid Nanoparticles - Related Videos
08:19
Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
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Cited by 12 •
2015
In this study, a method for synthesizing ultra-small populations of biocompatible nanoparticles was described, as well as several in vitro methods by which to assess their cellular interactions.
10:26
Using In Vitro Live-cell Imaging to Explore Chemotherapeutics Delivered by Lipid-based Nanoparticles
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Cited by 7 •
2017
Live-cell imaging is a powerful tool to visualize dynamic processes. The examination of fixed cells provides only static pictures, which can lead to misinterpretation and confusion about the process. This work presents a method to study uptake, drug release, and intracellular localization of liposomal nanoparticles in living cells.
10:19
Synthesis and Testing of Supported Pt-Cu Solid Solution Nanoparticle Catalysts for Propane Dehydrogenation
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2017
A convenient method for the synthesis of 2 nm supported bimetallic nanoparticle Pt-Cu catalysts for propane dehydrogenation is reported here. In situ synchrotron X-ray techniques allow for the determination of the catalyst structure, which is typically unobtainable using laboratory instruments.
07:19
Determining the Density of a Solid and Liquid
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2023
Source: Laboratory of Dr. Michael Evans — Georgia Institute of Technology The ratio of the mass of a substance to its volume is known as the mass density or, simply, the density of the substance. Density is expressed in units of mass per volume, such as g/mL or kg/m3. Because the density of a substance does not depend on the amount of substance present, density is an “intensive property”. To measure the density of a sample of material, both the mass and volume of the sample must be determined.
07:33
Tethered Bilayer Lipid Membranes to Monitor Heat Transfer between Gold Nanoparticles and Lipid Membranes
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Cited by 3 •
2020
This work outlines a protocol to achieve dynamic, non-invasive monitoring of heat transfer from laser-irradiated gold nanoparticles to tBLMs. The system combines impedance spectroscopy for the real-time measurement of conductance changes across the tBLMs, with a horizontally focused laser beam that drives gold nanoparticle illumination, for heat production.
FAQs
The lipid matrix provides the structural environment for incorporating active compounds, particularly molecules with poor water solubility. Surfactants stabilize the resulting colloidal suspension and modify particle surface properties. Together, these components affect how much compound can be incorporated, how the particles behave in aqueous media, and how the active compound is released.
Maintaining the lipid matrix in a solid state at room or physiological temperature supports particle integrity during use. This state can help incorporate poorly water-soluble compounds while contributing to their stability and controlled release. Consequently, the physical state of the lipid is central to how the formulation protects and transports its active cargo.
Both composition and preparation conditions influence the key properties of Solid Lipid Nanoparticles. Changes in the lipid matrix or surfactant system can alter particle size, surface behavior, and the amount of compound incorporated. Preparation conditions also affect crystallinity and release behavior, so these variables must be considered together during formulation design.
A nanoparticle formulation can improve the aqueous dispersibility and stability of an active compound compared with the free molecule. The lipid matrix and stabilizing surfactants create a structured colloidal system that can also modify release. These changes are especially relevant for poorly water-soluble molecules whose handling and performance may be limited in free form.
Formulation development begins by selecting a lipid matrix capable of incorporating the active compound, then establishing a surfactant system that stabilizes the particle suspension. Researchers vary composition and preparation conditions to obtain a suitable colloidal formulation. The resulting material is evaluated for particle size, crystallinity, encapsulation efficiency, and release behavior.
They are useful when researchers need to formulate active compounds that are poorly water-soluble or require improved stability and aqueous dispersibility. The platform supports investigation of how lipid composition, surfactant choice, and preparation conditions affect delivery-related properties. It therefore serves both as a formulation strategy and as a system for studying structure-property relationships.
Evaluation should include particle size, crystallinity, encapsulation efficiency, and release behavior because these measurements describe different aspects of formulation performance. Particle size characterizes the colloidal system, crystallinity indicates the state of the lipid matrix, encapsulation efficiency measures compound incorporation, and release behavior shows how the formulation controls active-compound availability over time.