Dmpc Dmpe-dtpa
Dmpc Dmpe-dtpa - Related Videos
11:22
Investigations on the Ga(III) Complex of EOB-DTPA and Its 68Ga Radiolabeled Analogue
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Cited by 2 •
2016
A procedure for the isolation of EOB-DTPA and subsequent complexation with natural Ga(III) and 68Ga is presented herein, as well as a thorough analysis of all compounds and investigations on labeling efficiency, in vitro stability and the n-octanol/water distribution coefficient of the radiolabeled complex.
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Online Repetitive Transcranial Magnetic Stimulation of Dorsomedial and Dorsolateral Prefrontal Cortex in Cognition Decision Making, and Cognitive Dissonance
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2025
This protocol presents a more precise and effective method of repetitive transcranial magnetic stimulation of the dorsolateral and dorsomedial prefrontal cortices during an experimental task using neuronavigation and robotic systems. Based on the results, crucial implications are suggested for future online stimulation research.
16:24
Controlling the Size, Shape and Stability of Supramolecular Polymers in Water
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Cited by 13 •
2012
The goal of this experiment is to determine and control the size, shape and stability of self-assembled discotic amphiphiles in water. For aqueous based supramolecular polymers such level of control is very difficult. We apply a strategy using both repulsive and attractive interactions. The experimental techniques applied to characterize this system are broadly applicable.
07:26
High-throughput Crystallization of Membrane Proteins Using the Lipidic Bicelle Method
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Cited by 27 •
2012
Bicelles are lipid/amphiphile mixtures that maintain membrane proteins (MPs) within a lipid bilayer but have unique phase behavior that facilitates high-throughput screening by crystallization robots. This technique has successfully produced a number of high-resolution structures from both prokaryotic and eukaryotic sources. This video describes protocols for generating the lipidic bicelle mixture, incorporating MPs into the bicelle mixture, setting up crystallizations trials (manually as well...
09:29
The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies
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Cited by 81 •
2015
Due to its multi-day radioactive half-life and favorable decay properties, the positron-emitting radiometal 89Zr is extremely well-suited for use in antibody-based radiopharmaceuticals for PET imaging. In this protocol, the bioconjugation, radiosynthesis, and preclinical application of 89Zr-labeled antibodies will be described.
FAQs
The DTPA-modified phosphatidylethanolamine presents chelating groups at the membrane interface, where multiple donor sites can coordinate metal ions. Meanwhile, the lipid components maintain their bilayer organization in aqueous conditions. This separation of functions allows metal binding to alter surface chemistry while preserving the structural arrangement needed for engineered membrane systems.
Aqueous conditions enable the amphiphilic lipid components to organize into bilayers rather than remaining as isolated molecules. That organization creates a continuous membrane interface and positions the DTPA groups for access to surrounding metal ions. Consequently, researchers can combine an assembled lipid structure with controllable interfacial coordination chemistry in one material.
Multiple donor sites allow a DTPA group to chelate metal ions through several coordination points rather than relying on a single interaction. This gives the membrane interface a defined metal-binding function and supports selective incorporation of ions. The resulting coordination environment can be used to tune interfacial properties without requiring major changes to membrane organization.
DMPE-DTPA adds a metal-responsive surface function to the membrane while DMPC contributes to the lipid bilayer system. The modified component therefore extends the membrane beyond structural assembly, making its interface chemically addressable through metal coordination. This combination is useful when an engineered membrane must retain organized lipid structure while also interacting with selected metal ions.
The system provides several linked design variables: lipid bilayer assembly, surface chemistry, metal-ion incorporation, and interfacial coordination. Engineers can use these features to develop membrane materials whose organization is maintained while their interface is chemically modified. Such control supports the construction of nanostructured materials in which lipid assembly and metal binding contribute to performance.
Supported applications include liposomes, biosensing platforms, molecular probes, and other nanostructured materials. In each case, the membrane supplies an organized lipid interface, while DTPA groups provide metal-binding functionality. This pairing is relevant when a design requires controlled surface chemistry or selective metal coordination rather than lipid assembly alone.