Gold Microcarriers
Gold Microcarriers - Related Videos
04:13
Bioscaffold Fabrication by Electrospraying: A Technique to Generate Microcarrier Scaffolds Derived from Extracellular Matrix of Decellularized Tissue
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2023
This video demonstrates the procedure of extracellular matrix-derived microcarrier fabrication by electrospraying. These microcarriers simulate the native tissue-specific microenvironment and are stable in long-term 3D in vitro cell culture models.
09:31
Gold Nanorod-assisted Optical Stimulation of Neuronal Cells
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Cited by 9 •
2015
This protocol outlines how to use the transient heating associated with the optical absorption of gold nanorods to stimulate differentiation and intracellular calcium activity in neuronal cells. These results potentially open up new applications in neural prostheses and fundamental studies in neuroscience.
08:21
Fabrication of Periodic Gold Nanocup Arrays Using Colloidal Lithography
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Cited by 1 •
2017
We demonstrate the fabrication of periodic gold nanocup arrays using colloidal lithographic techniques and discuss the importance of nanoplasmonic films.
08:55
Hydroquinone Based Synthesis of Gold Nanorods
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Cited by 11 •
2016
This paper describes a protocol for the synthesis of gold nanorods, based on the use of hydroquinone as reducing agent, plus the different mechanisms for controlling their size and aspect ratio.
13:42
Gold Nanoparticle Synthesis
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Cited by 2 •
2021
A protocol for synthesizing ~12 nm diameter gold nanoparticles (Au nanoparticles) in an organic solvent is presented. The gold nanoparticles are capped with oleylamine ligands to prevent agglomeration. The gold nanoparticles are soluble in organic solvents such as toluene.
FAQs
DNA, proteins, or other biomolecules first adhere to the gold surface. After coated particles reach the target tissue, cells take them up, allowing the attached cargo to act within the experimental system. This sequence links particle deposition with downstream biological effects, making cellular uptake a central factor when investigators interpret gene-transfer, antigen-delivery, or immune-response results.
Gold provides a stable, relatively inert surface that can carry biological materials without becoming the primary experimental stimulus. Its carrier role helps investigators focus on how the delivered DNA, protein, antigen, or other biomolecule influences cells and tissues. This separation is especially useful when evaluating immune activation or responses to candidate interventions in infection research.
Outcomes depend on the biological material attached to the particles, the tissue selected for delivery, and whether cells successfully take up the coated particles. These factors determine whether the cargo can act and what host response becomes measurable. Consequently, investigators must interpret delivery results together with the intended cargo, target tissue, and observed immune response rather than considering particle presence alone.
A typical workflow begins by associating DNA, proteins, or other biomolecules with the gold surface. The coated particles are then accelerated into the selected target tissue, where cellular uptake enables the cargo to function. Researchers can subsequently examine the resulting biological activity, such as gene transfer, antigen-related effects, or host responses relevant to immunology and infection.
They can deliver vaccine-related materials, including antigens or other immune-stimulating biomolecules, directly into target tissue. Once cells take up the coated particles, investigators can evaluate how the delivered material influences immune responses. This makes the approach useful for comparing candidate vaccine strategies and examining whether a controlled delivery format produces measurable host responses.
The approach supports studies of antigen delivery, gene transfer, and host responses to pathogens or candidate interventions. By transporting selected biomolecules into cells or tissues, it gives researchers a way to connect a defined experimental cargo with subsequent immune effects. Its relevance extends from investigating infection-related responses to assessing materials intended to modify or stimulate those responses.