Mouse Ankle Joint
Mouse Ankle Joint - Related Videos
01:10
Ankle Joint
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2023
The ankle is formed by the talocrural joint (crural = leg). It consists of the articulations between the talus bone of the foot and the distal ends of the tibia and fibula of the leg. The superior aspect of the talus bone is square-shaped and has three areas of articulation. The top of the talus articulates with the inferior tibia. This is the portion of the ankle joint that carries the body weight between the leg and foot. The sides of the talus are firmly held in position by the articulations...
09:14
A Mouse Model of Ankle-Subtalar Complex Joint Instability
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Cited by 1 •
2022
The ankle-subtalar complex joint (ASCJ) is the core of the foot and plays a key role in balance control in daily activities. Sports injuries often lead to instability in this joint. Here, we describe a mouse model of ligament transection-induced instability of the ASCJ.
08:33
Ankle Exam
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2023
Source: Robert E. Sallis, MD. Kaiser Permanente, Fontana, California, USA The ankle and foot provide the foundation for the body and the stability needed for upright posture and ambulation. Because of its weight-bearing function, the ankle joint is a common site of injury among athletes and in the general population. Ankle injuries occur as a result of both acute trauma and repetitive overuse (such as running). The ankle is a fairly simple joint, consisting of the articulation between the...
10:10
In Vivo Imaging Uncovers the Migratory Behavior of Leukocytes within the Joints
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2025
In vivo imaging of the joints is a valuable technique for uncovering the migratory behavior of leukocytes and molecular dynamics within the inflamed joints. Here, we present a detailed protocol for in vivo imaging of the joints using a murine model of type II collagen-induced arthritis (CIA).
09:01
Treatment of Ankle Osteoarthritis with Total Ankle Replacement Through a Lateral Transfibular Approach
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Cited by 15 •
2018
We present our preoperative, operative, and postoperative protocols for the treatment of osteoarthritis of the ankle with total ankle replacement via lateral transfibular approach.
FAQs
Inflammatory activation can produce vascular changes in the joint, followed by cytokine release and recruitment of leukocytes into affected tissues. These events connect an initiating immune signal or microbial challenge with visible swelling and cellular infiltration. Examining them together helps researchers determine how rapidly inflammation develops and how strongly local immune activity contributes to joint pathology.
Cytokines act as signaling molecules that coordinate local immune activity, while leukocytes are recruited into the joint and surrounding tissues. Their combined activity can amplify inflammation and contribute to tissue damage or remodeling. Measuring cytokine production alongside cellular infiltration therefore provides complementary evidence, linking molecular immune signaling with the anatomical severity of the response.
The model supports parallel evaluation of inflammatory responses and structural injury. Researchers can examine swelling, cytokine production, leukocyte infiltration, and histopathological changes to determine whether disease features reflect immune activation, microbial invasion, pathogen-associated damage, or overlapping processes. This comparison is useful for connecting local tissue findings with the mechanisms responsible for infection-related arthritis.
Tissue remodeling indicates that inflammation has affected the organization or condition of joint structures beyond an immediate immune response. When interpreted with histopathological findings, remodeling can help relate persistent inflammation to changes in cartilage, bone, synovial lining, or surrounding tissues. It therefore adds structural context to measurements of cytokines, leukocyte recruitment, and disease severity.
A focused assessment can combine joint swelling, cellular infiltration, cytokine production, and histopathological changes. Swelling provides an observable measure of local disease severity, whereas cellular and molecular readouts reveal immune activity. Histopathology adds structural information about affected tissues. Together, these outcomes allow researchers to compare inflammatory burden across experimental conditions or treatment groups.
Its defined anatomical site allows investigators to examine inflammation and tissue injury within a localized joint environment. In arthritis studies, researchers can relate immune activation to swelling, leukocyte accumulation, cytokines, and structural changes. In infection studies, the same readouts help characterize pathogen-associated damage and connect local pathology with the severity of the disease process.
Treatment effects can be assessed by comparing changes in swelling, cytokine production, cellular infiltration, and histopathological features. Improvement across these measures may indicate reduced local inflammation or tissue injury, while discordant results can show whether a therapy affects immune signaling, leukocyte recruitment, or structural damage differently. This multidimensional approach strengthens interpretation of therapeutic outcomes in arthritis or infection research.