Aortic Interposition
Aortic Interposition - Related Videos
05:40
A Mouse Aortic Interposition Model to Study Alloimmune-Induced Vascular Rejection
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2025
This video demonstrates a method for generating a mouse aortic interposition model to study alloimmune-induced vascular rejection. After placing an anesthetized donor mouse in the supine position, the infrarenal abdominal aorta (IAA) is carefully isolated from surrounding structures. Branching vessels are ligated, and both ends of the IAA are clamped to prevent blood flow before resection. Subsequently, the donor IAA is implanted into an allogeneic recipient mouse, and blood flow is restored...
12:39
Implantation of Inferior Vena Cava Interposition Graft in Mouse Model
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Cited by 24 •
2014
To improve our knowledge of cellular and molecular neotissue formation, a murine model of the TEVG was recently developed. The grafts were implanted as infrarenal vena cava interposition grafts in C57BL/6 mice. This model achieves similar results to those achieved in our clinical investigation, but over a far shortened time-course.
12:17
Full-root Aortic Valve Replacement by Stentless Aortic Xenografts in Patients with Small Aortic Roots
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Cited by 4 •
2017
Full-root aortic valve replacement by stentless aortic xenograft is a viable option in patients with small aortic roots. We describe, a technique for the full-root implantation of stentless aortic xenografts, with emphasis on the management of the proximal suture line and coronary anastomoses, and discuss its limitations and alternative options.
09:12
Aortic Ring Assay
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Cited by 42 •
2009
Angiogenesis, the sprouting of blood vessels from pre-existing vasculature, is associated with both natural and pathological processes. Here we demonstrate an aortic ring assay that allows angiogenic potentiators and inhibitors to be directly added to aortic rings in culture. Sprouting and neovessel outgrowth can be determined by inspecting the aortic rings over a period of 6-12 days.
07:08
Optimization of Synthetic Proteins: Identification of Interpositional Dependencies Indicating Structurally and/or Functionally Linked Residues
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Cited by 1 •
2015
Synthetic protein sequences based on consensus motifs typically ignore co-evolving residues, that imply interpositional dependencies (IPDs). IPDs can be essential to activity, and designs that disregard them may result in suboptimal results. This protocol uses StickWRLD to identify IPDs and help inform rational protein design, resulting in more efficient results.
FAQs
Graft selection must match the affected aortic location and the patient’s condition. Surgeons may choose a prosthetic or biologic graft, with the selected material serving as the conduit between viable aortic segments. This decision influences how the reconstruction is connected to healthy tissue and supports restoration of durable blood flow after the diseased segment is treated.
Proximal and distal anastomoses create the junctions between the graft and healthy aortic tissue. Their integrity determines whether continuity is restored across the repaired segment and whether blood can pass effectively through the reconstruction. Careful anastomotic technique is therefore central to limiting complications and supporting favorable long-term vascular outcomes.
Temporary control of circulation allows surgeons to work on the affected aortic segment while managing blood flow through the operative field. The diseased or damaged portion can then be removed or bypassed before the graft is connected. Because blood-flow management is integral to the operation, perioperative planning must reflect the aortic location and patient condition.
The procedure generally begins with temporary control of circulation, followed by removal or bypass of the affected segment. A suitable graft is positioned between healthier portions of the aorta, and surgeons create proximal and distal anastomoses to secure continuity. The reconstruction is then assessed in the context of restoring blood flow and limiting complications.
Aortic interposition may be considered for aneurysms, traumatic injury, occlusive disease, and selected congenital abnormalities. The suitability of the approach depends on where the aorta is affected and on the patient’s overall condition. These factors also guide graft selection, the reconstruction strategy, and the way circulation is managed during surgery.
The immediate goal is to re-establish continuity and blood flow across the affected aortic region. Longer-term objectives include reducing complications and achieving durable vascular function. Outcomes depend on coordinated graft selection, secure anastomoses, and effective perioperative blood-flow management, all adapted to the disease process, aortic location, and individual patient condition.