Detubularized Ileal Patch
Detubularized Ileal Patch - Related Videos
04:58
Mouse Ileal Loop Model: A Surgical Model to Study Intestinal Permeability in the Mouse
0 Views •
2025
This video demonstrates the generation of an ileal loop model to study intestinal permeability in a mouse model. This method provides a live model to understand the epithelial barrier function and consequent immune response.
04:35
Murine Ileal Resection Model: Studying Ileectomy-Induced Bile Metabolism in Murine Model
0 Views •
2023
This video describes the detailed protocol for intestinal resection in a murine model. This technique provides insights into ileectomy-induced bile malabsorption, overaccumulation, and toxicity in the mouse intestine.
09:43
Patch Clamp Electrophysiology
0 Views •
2023
Neuron cell membranes are populated with ion channels that control the movement of charge into and out of the cell, thereby regulating neuron firing. One extremely useful technique for investigating the biophysical properties of these channels is called patch clamp recording. In this method, neuroscientists place a polished glass micropipette against a cell and apply suction to form a high resistance seal. This process isolates a small “patch” of membrane that contains one or more ion channels.
01:02
Long-patch Base Excision Repair
0 Views •
2020
Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are: Lesion type: Depending on the type of base damage, a specific DNA glycosylase - mono or bifunctional, is recruited to the damaged site. While the sequential action of a monofunctional glycosylase favors long patch repair...
06:02
Isolation of Lymphocytes from a Mouse Peyer's Patch
0 Views •
2025
In this video, we demonstrate the isolation of lymphocytes from a harvested mouse Peyer's patch. The isolated lymphocytes can be used for further analysis.
FAQs
The antimesenteric incision changes the isolated ileal segment from a narrow tube into a broad sheet of tissue. Reconfiguring that sheet allows it to expand with the bladder rather than preserve the restrictive geometry of the bowel segment. This remodeling supports greater storage capacity while helping keep bladder pressures lower during filling.
A detubularized ileal patch provides a broader, more compliant surface for bladder enlargement. Because the tissue no longer retains the original tube-like configuration, the reconstructed bladder can accommodate additional urine with less pressure increase. This pressure-related effect is clinically important when poor bladder compliance threatens effective storage or may place the upper urinary tract at risk.
An intact ileal segment retains a cylindrical form, whereas the reconstructed patch is opened and spread into a wider configuration. That geometric difference, rather than simply adding intestinal tissue, determines how the augmentation contributes to bladder expansion. The patch is therefore designed to provide capacity while reducing the high storage pressures associated with a poorly compliant bladder.
The procedure begins by isolating a selected segment of ileum. Surgeons then open it longitudinally along the antimesenteric border and reshape the opened tissue into a broad patch. Finally, they anastomose, or surgically connect, the patch to the urinary bladder. These steps convert the bowel segment into an enlargement surface rather than leaving it tubular.
This approach is used selectively for patients whose bladder has reduced capacity or poor compliance. Neurogenic bladder is one clinical setting in which it may be considered, although candidacy depends on the individual reconstruction context. The central rationale is to improve urinary storage when the native bladder cannot maintain adequate capacity at acceptable pressures.
The intended outcomes are increased bladder capacity and improved urinary storage, together with lower storage pressures. By changing the bladder’s pressure and capacity characteristics, the reconstruction can also support protection of the upper urinary tract. These goals explain its relevance in selected patients with significant storage dysfunction, including some individuals with neurogenic bladder.